20 A multi-centre UK clinical experience with wireless intracardiac left ventricular endocardial stimulation for delivery of cardiac resynchronisation therapy (WiSE CRT).

Introduction: A significant minority of patients fail to derive clinical benefit from cardiac resynchronisation therapy (CRT) delivered via an epicardial LV lead and many patients requiring an upgrade can have unfavourable central or coronary venous anatomy. CRT delivered through LV endocardial stimulation has demonstrated superior haemodynamic and electrical properties; access to the entire myocardium presents additional opportunity to identify the optimal LV site which appears to be patient specific. We evaluated the clinical effectiveness and safety of a wireless intracardiac LV electrode pacing system, for delivery of CRT (WiSE-CRT). An  electrode is implanted into the LV endocardium and a separate ultrasound transmitter (attached via cable to a battery) implanted onto the intercostal muscle. A LV stimulus is delivered within 3ms of sensing an RV stimulus from an existing transvenous pacing system.
Source: Europace - Category: Cardiology Source Type: research