Organs needed

With Scotland set to join Wales in having an "opt-out" system for organ donation, why are England and Northern Ireland not following suit?
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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This article discusses whether paid living unrelated donation in Iran increases riskier donations and reduced altruistic donation as opponents of paid donation claim. The paper debates whether objections to paid donation based upon commodification arguments only oppose enabling financial ends, even if these ends enable beneficent acts. Discussions in relation to whether valid consent can be given by the donor will take place and will also debate the objection that donors will be coerced and exploited by a paid model. This article suggests that exploitation of the paid donor within the Iranian model exists within the legall...
Source: Nursing Ethics - Category: Nursing Authors: Tags: Nurs Ethics Source Type: research
Abstract Organ transplantation is one of the most critical ethical topics in law and medicine and a matter of debate in various countries. Lack of organs for engraftment to meet the existing demand has resulted in a substantial crisis due to organ shortage and a rise in the critical conditions of certain waitlisted patients, as well as increased mortality of patients while waiting. Organ shortages for transplantation raised the issue of procurement of organs not only from living donors and cadaveric donors after brain death, but also after circulatory death. Renewed interest in donation after circulatory death sta...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Abstract PURPOSE OF REVIEW: With an increasing demand for donor organs, strategies to increase the number of available donor organs have become more focused. Compensating donors for donation is one strategy proposed to increase the availability of organs for transplant. This has been implemented in several systems internationally, but debate continues in the United States with respect to appropriate strategies. The National Organ Transplant Act (NOTA) currently prohibits the transfer of any human organ 'for valuable consideration' for transplantation, but allows for the removal of financial disincentives. REC...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
AbstractThe continuing shortage of deceased donor organs for transplantation, and the limited number of potential donors after brain death, has led to a resurgence of interest in donation after circulatory death (DCD). The processes of warm and cold ischemia threaten the viability of DCD organs, but these can be minimized by well-organized DCD pathways and new techniques of in situ organ preservation and ex situ resuscitation and repair post-explantation. Transplantation survival after DCD is comparable to donation after brain death despite higher rates of primary non-function and delayed graft function. Countries with suc...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Julie McDowall (@JulieAMcDowall) usually writes about nuclear war, in fact she’s got a book on that subject coming out soon. But, a few days ago she mentioned on Twitter that she has synaesthesia (the condition where the senses are “mixed up”, so that a person with condition can smell music or see colours when they touch different textures). She said that to her different names conjure up different tastes. Needless to say, everyone who follows her on Twitter wants to know what their name tastes like. The thread has gone viral, she has had 6 million twitter interactions as of 29th January. She has been tr...
Source: David Bradley Sciencebase - Songs, Snaps, Science - Category: Science Authors: Tags: Sciencebase Source Type: blogs
ConclusionThe DDDWG developed recommendations for proposed definitions and data sources that should be adopted nationally to guide the collection of deceased donation data. The ultimate purpose of the final minimum data set is to harmonize and standardize donation data definitions in Canada and align with international standards; inform the development of operational and clinical practice standards at the provincial and national levels; develop a framework for deceased donation performance measures; and advance the science of deceased donation.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
Patients receiving new kidneys and livers must take damaging anti-rejection drugs for the rest of their lives. Now researchers hope to train the immune system instead of just tamping it down.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Transplants Kidneys Organ Donation Liver Immune System Drugs (Pharmaceuticals) Dana-Farber Cancer Institute Massachusetts General Hospital University of Pittsburgh Medical Center Pittsburgh (Pa) Source Type: news
IT IS WELL-KNOWN that hormonal changes occur after brain death. Pituitary failure ensues, which results in low triiodothyronine (T3) and thyroxine (T4) levels and an acutely hypothyroid state. Catecholamines are released, which can result in an increased systemic vascular resistance, decreased cardiac output, and decreased left ventricular dysfunction. There are conflicting data regarding the hormonal and hemodynamic collapse that can render organs not suitable for donation.1 Ventricular contractility is reduced, associated with alterations in cardiac myosin fibers and changes to calcium channel function.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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