U.S. FDA Approves Serenity Pharmaceuticals Noctiva(TM) (desmopressin acetate) the First Drug Approved for the Treatment of Nocturia
MILFORD, Pa.--(Healthcare Sales &Marketing Network)--Serenity Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) approved Noctiva (desmopressin acetate) nasal spray for the treatment of nocturia due to nocturnal polyuria in adults... Biopharmaceuticals, FDA Serenity Pharmaceuticals, Noctiva, desmopressin, nocturia
In this study, we performed molecular dynamics simulations to provide quantitative comprehension of the thin brine film characteristics that wets carbonate reservoir rocks at molecular level. While an electric double layer is formed at the interface of calcite/low salinity water, the ions in the high saline water form several aggregates of ions. We found that these aggregates persist inside the nano-layer brine separating oil film from carbonate surface and act as anchors that hold oil components in the vicinity of the substrate. This phenomenon is suggested to be responsible for oil attachment to the carbonate reservoirs ...
Conditions: Sleep Fragmentation; Poor Quality Sleep; Nocturia; Nocturnal Enuresis Interventions: Behavioral: BBTI; Behavioral: IC Sponsors: University of Pittsburgh; National Institute on Aging (NIA) Recruiting
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b22206
CONCLUSIONSurgeons should be aware of the persistent renal defects caused by long term lithium use and development of nephrogenic diabetes insipidus even years after medication cessation.
CONCLUSIONS: Patients with hemophilia A treated with bypassing agents between 2007 and 2014 incurred substantially higher monthly hemophilia-related medical and pharmacy costs than patients treated only with FVIII replacement. PMID: 30888200 [PubMed - as supplied by publisher]
The pathophysiology and genetic influences in nocturnal enuresis have not been fully elucidated. Delayed neuronal maturation has been suggested as a pathogenetic mechanism in primary monosymptomatic nocturnal enuresis (PMNE). Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are neurotrophins affecting maturation of the nervous system.
ConclusionsPerampanel is effective against various types of seizures, including ES, in pediatric patients with refractory epilepsy. Furthermore, PER has good tolerability when the dose is adjusted based on serum concentrations. The PER CD ratio was lower in pediatric patients than in adolescents and adults; therefore, clinicians must consider the CD ratio when treating children with PER.
In this study, a review of the existing literature on the individualization of dosing based on PK guidance was performed. In total, 79 articles were included. The methods to individualize dosing were divided into 3 categories: (1) methods using clinical parameters, (2) empirical individual PK-guided methods, and (3) maximum a posteriori (MAP) Bayesian estimation methods. The clinical parameter mainly used to individualize dosing is bleeding phenotype. Dosing based on bleeding phenotype may decrease clotting factor consumption. However, with this method, it is not possible to individualize on-demand dosing during bleeding e...
ConclusionThe pharmacologic profile of chlorobutanol (synergistic IKR block) and its association with reports of TdP and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations.