MRI of glutamate shows promise in ischemic stroke

Chinese researchers have concluded that MRI of glutamate concentrations in (more)
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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(Natural News) Is there really “good” cholesterol and “bad” cholesterol? The medical community has branded low density lipoprotein, or LDL, cholesterol “bad” because high levels are linked to plaque buildup in the arteries, heart disease, and risk of ischemic stroke. However, a new study from Penn State University argues that LDL cholesterol is necessary in...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This study aimed to investigate the potential roles of Nogo-A/Nogo-66 receptor 1 (NgR1) in autophagic activation in the ipsilateral thalamus after cerebral infarction. Focal neocortical infarction was established using the middle cerebral artery occlusion (MCAO) method. Secondary damage in the ipsilateral thalamus was assessed by Nissl staining and immunostaining. The expression of Nogo-A, NgR1, Rho-A and Rho-associated coiled-coil containing protein kinase 1 (ROCK1) as well as autophagic flux were evaluated by immunofluorescence and immunoblotting. The roles of Nogo-A-NgR1 signaling in autophagic activation were determine...
Source: Neuroscience - Category: Neuroscience Source Type: research
Authors: Xie X, Li T Abstract Objective: We investigated the risk of ischaemic stroke in patients with 1 another stroke risk factor (i.e. CHA2DS2-VASc score =1 [males] or 2 [females]) and the impact of different component risk factors.Methods: Database were collected from two hospitals in the city of Hohhot in china. Among 3148 Nonvalvular AF patients not on antiplatelet or anticoagulant therapy, we evaluated males with a CHA2DS2-VASc score of 1 and females with a CHA2DS2-VASc score of 2. The clinical endpoint was the occurrence of ischaemic stroke.Results: Among 546 AF male patients with a CHA2DS2-VASc scor...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Conclusion: Our meta-analysis suggests that uninterrupted DOAC is not superior to VKA in patients undergoing catheter ablation of AF with comparable rates of major bleeding and stroke. PMID: 32056498 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Toyoda S, Tokoi S, Takekawa H, Matsumoto H, Inami S, Sakuma M, Arikawa T, Abe S, Nakajima T, Hirata K, Inoue T Abstract BACKGROUND: Although flow-mediated vasodilation (FMD) of brachial artery and carotid intima-media thickness (IMT) are important surrogate markers in the process of atherosclerosis, information about relationship between both markers is insufficient. In the present study, we assessed extensively the relationship in patients with coronary artery disease (CAD). METHODS: The values of brachial FMD and carotid ultrasonography findings in 159 patients (67±8 yr, 130 males) with angiog...
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
Authors: Ornello R, Canonico M, Merki-Feld GS, Kurth T, Lidegaard Ø, MacGregor EA, Lampl C, Nappi RE, Martelletti P, Sacco S Abstract Introduction. Migraine and combined hormonal contraceptives (CHCs) increase the risk of ischemic stroke in young women; however, the contribution of low-dose (
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Publication date: Available online 14 February 2020Source: Journal of Clinical NeuroscienceAuthor(s): Hyuk Sung Kwon, Eun-Hye Lee, Hyun-Hee Park, Jeong-Hwa Jin, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Jae-Hong Lee, Felipe Marques Souza de Oliveira, Hyun Young Kim, Young Seo Kim, Bum Joon Kim, Sung Hyuk Heo, Dae-Il Chang, Masood Kamali-Moghaddam, Seong-Ho KohAbstractSoluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
This study investigated the long-term effects of dihydrocapsaicin (DHC)-induced angiogenesis and improved functional outcomes in cerebral ischemia and reperfusion (I/R) rats. Middle cerebral artery occlusion was induced in I/R rats for 2 h, followed by reperfusion. The animals were divided into three groups: sham, I/R + vehicle, and I/R + DHC (10 mg/kg body weight). Fourteen days after I/R injury, the DHC-treated I/R rats had decreased neurological deficit scores, infarct volume, and brain morphology changes. DHC-induced angiogenesis significantly increased the expression of angiogenic factor proteins, such as hypoxia indu...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 13 February 2020Source: CellAuthor(s): Christoph Kirst, Sophie Skriabine, Alba Vieites-Prado, Thomas Topilko, Paul Bertin, Gaspard Gerschenfeld, Florine Verny, Piotr Topilko, Nicolas Michalski, Marc Tessier-Lavigne, Nicolas RenierSummaryThe cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying variations of the vascular organization across individuals, brain regions, or disease models is challenging. We used immunolabeling and tissue clearing to image the vascular network of adult mouse brains and developed a pipeline to segment terabyte-sized multichann...
Source: Cell - Category: Cytology Source Type: research
Patency of the middle cerebral artery (MCA) in acute ischemic stroke with internal carotid artery (ICA) occlusions is associated with less severe stroke and favorable outcomes. However, thrombus migration to distal intracranial vessels may lead to unfavorable outcomes. We investigated the influence of thrombus migration on clinical outcomes in patients with ICA occlusions and patent MCA.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
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