Systematic Drug Repurposing Through Text Mining
Drug development remains a time-consuming and highly expensive process with high attrition rates at each stage. Given the safety hurdles drugs must pass due to increased regulatory scrutiny, it is essential for pharmaceutical companies to maximize their return on investment by effectively extending drug life cycles. There have been many effective techniques, such as phenotypic screening and compound profiling, which identify new indications for existing drugs, often referred to as drug repurposing or drug repositioning. This chapter explores the use of text mining leveraging several publicly available knowledge resources and mechanism of action representations to link existing drugs to new diseases from biomedical abstracts in an attempt to generate biologically meaningful alternative drug indications.
A growing link—what is the role of height in cancer risk?A growing link—what is the role of height in cancer risk?, Published online: 19 February 2019; doi:10.1038/s41416-018-0370-9A growing link—what is the role of height in cancer risk?
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults, Published online: 19 February 2019; doi:10.1038/s41416-018-0371-8Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
A new CDC report brings the nationwide total of people who have been infected with salmonella after eating contaminated turkey to 279 in 41 states and the District of Columbia.
(Reuters Health) - Almost half of women and a quarter of men leave careers in science, technology, engineering and math after they have their first child, a new study shows.
The Ohio Department of Health says reports that wrongly imply a newly declared outbreak of hepatitis A are circulating around the state, apparently prompted by a recent case involving a restaurant worker
Publication date: Available online 18 February 2019Source: Mechanics of MaterialsAuthor(s): Dinesh Chandra Pant, Siladitya PalAbstractPorous shape memory alloy (SMA) materials being porous structures combined with the behaviors of SMA material can offer tremendous potential for future energy absorbing structural components. Although several studies have been performed in recent past to examine the influence of pores towards phase transformation, they are limited to quasi-static loading conditions. Investigation of phase transformation and associated energy dissipation for porous structural component made of SMA materials i...
Publication date: Available online 18 February 2019Source: Mechanics of MaterialsAuthor(s): Akhileshwar Singh, Dinesh KumarAbstractThe present paper is focused on developing and using a multiscale approach to investigate the effect of functionalization of graphene with carboxyl (-COOH) group on the overall elastic properties of graphene nanoplatelet (GNP) -reinforced polyethylene nanocomposites, considering the interfacial effect. The current study involves three aspects. First, MD simulations are performed at the nanoscale to evaluate the elastic properties of pristine and functionalized graphene, polyethylene matrix, and...
Publication date: Available online 18 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Michael A. Emery, Shoshana EitanAbstractPain management is the specialized medical practice of modulating pain perception and thus easing the suffering and improving the life quality of individuals suffering from painful conditions. Since this requires the modulation of the activity of endogenous systems involved in pain perception, and given the large role that the opioidergic system plays in pain perception, opioids are currently the most effective pain treatment available and are likely to ...
Publication date: Available online 18 February 2019Source: Journal of Psychiatric ResearchAuthor(s): John W. Rutland, Stephanie Brown, Gaurav Verma, Rebecca E. Feldman, Himanshu Sharma, Matthew Markowitz, Molly Schneider, Bradley N. Delman, James Murrough, Priti BalchandaniAbstractObjectiveDiffusion magnetic resonance imaging (dMRI) enables non-invasive characterization of white matter (WM) structures in vivo. Prior studies suggest that certain WM tracts may be affected in major depressive disorder (MDD), however, hippocampal subfield-specific dMRI measures have not yet been explored in MDD. We use 7 Tesla dMRI to investig...
Finding out you have a chronic illness — one that will, by definition, never go away — changes things, both for you and those you love.
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