Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model.

Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model.
Surg Innov. 2016 Oct 26;:
Authors: Jaiswal AK, Chhabra H, Narwane S, Rege N, Bellare JR
Abstract
This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.
PMID: 27789845 [PubMed - as supplied by publisher]

Source: Surgical Innovation - October 25, 2016 Category: Surgery Authors: Jaiswal AK, Chhabra H, Narwane S, Rege N, Bellare JR Tags: Surg Innov Source Type: research