Reconsidering risk factors for renal dysfunction in lithium-treated patients

ABSTRACT FROM: Clos S, Rauchhaus P, Severn A, et al. Long-term effect of lithium maintenance therapy on estimated glomerular filtration rate in patients with affective disorders: a population-based cohort study. Lancet Psychiatry 2015;2:1075–83. What is already known on this topic Over the past 6 years, a series of studies have investigated risk factors for renal dysfunction in lithium-treated patients, following the 2010's report that end-stage renal disease is an uncommon but not rare consequence of long-term lithium treatment and is more prevalent than previously thought.1 Besides risk factors already known to be involved in renal dysfunction, such as age, hypertension, diabetes and use of non-steroidal anti-inflammatory drugs, there may be additional risk factors specific for this context, including receiving a diagnosis of bipolar disorder, the principal indication of lithium maintenance. The latter possibility was suggested by a recent Danish nationwide population-based study whose aim was to compare...

Source: Evidence-Based Mental Health - October 20, 2016 Category: Psychiatry & Psychology Authors: Bocchetta, A. Tags: Electronic pages Source Type: research