Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against < b > < i > Propionibacterium acnes < /i > < /b >

Determination of the mutant prevention concentration (MPC) and the mutant selection window (MSW) of antimicrobial agents used to treat pathogenic bacteria is important in order to apply effective antimicrobial therapies. Here, we determined the MPCs of the major topical antimicrobial agents againstPropionibacterium acnes andStaphylococcus aureus which cause skin infections and compared their MSWs. Among the MPCs of nadifloxacin and clindamycin, the clindamycin MPC was determined to be the lowest againstP. acnes. In contrast, the nadifloxacin MPC was the lowest againstS. aureus. Calculations based on the minimum inhibitory concentrations and MPCs showed that clindamycin has the lowest MSW against bothP. acnes andS. aureus. Nadifloxacin MSWs were 4-fold higher againstP. acnes than againstS. aureus. It is more likely forP. acnes to acquire resistance to fluoroquinolones thanS. aureus. Therefore, topical application of clindamycin contributes very little to the emergence of resistantP. acnes andS. aureusstrains.Chemotherapy 2017;62:94-99
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research