Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption

Conclusions
Hepatic miR-21/miR-21* deficiency prevents glucose intolerance and steatosis in mice fed an obesogenic diet by altering the expression of several master metabolic regulators. This study points out miR-21/miR-21* as a potential therapeutic target for non-alcoholic fatty liver disease and the metabolic syndrome.

Source: Gut - October 6, 2016 Category: Gastroenterology Authors: Calo, N., Ramadori, P., Sobolewski, C., Romero, Y., Maeder, C., Fournier, M., Rantakari, P., Zhang, F.-P., Poutanen, M., Dufour, J.-F., Humar, B., Nef, S., Foti, M. Tags: Nonalcoholic steatosis, Hepatic cancer Hepatology Source Type: research