MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

Conclusions
Our findings reveal a novel mechanism by which microRNA-21, in part, promotes hepatic lipid accumulation and cancer progression by interacting with the Hbp1-p53-Srebp1c pathway and suggest the potential therapeutic value of microRNA-21-ASO for both disorders.

Source: Gut - October 6, 2016 Category: Gastroenterology Authors: Wu, H., Ng, R., Chen, X., Steer, C. J., Song, G. Tags: Nonalcoholic steatosis, Open access, Hepatic cancer Hepatology Source Type: research