A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion

Conclusions
Taken together, the rs1042058 GG IBD-risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying PRR-initiated outcomes.

Source: Gut - October 6, 2016 Category: Gastroenterology Authors: Hedl, M., Abraham, C. Tags: Crohn's disease Inflammatory bowel disease Source Type: research