A novel curcuminoid ‐tea polyphenol formulation: Preparation, characterization, and in vitro anti‐cancer activity

Abstract
Curcuminoids and tea polyphenols (CTP) are nutraceuticals with anticancer activity. To evaluate their combined in vitro anti‐cancer activity, the CTP mixture was loaded on solid lipid nanoparticles (SLNPs). The resulting CTP‐SLNPs were characterized and shown to have good chemical stability, making them suitable for delivery to cancer cells. A validated HPLC‐MS method was developed to monitor the composition and quality of the prepared CTP‐SLNP formulation, by identifying and quantifying its eight main components (epigallocatechin, epicatechin, catechin, epigallocatechingallate, epicatechingallate, curcumin, demethoxycurcumin and bisdemethoxycurcumin). The in vitro activity of CTP‐SLNPs was evaluated and shown to significantly inhibit the proliferation of HepG2 and CT‐26 cancer cells lines, indicating that anti‐cancer properties of curcuminoids and tea polyphenols were enhanced in the CTP‐SLNPs formulation. The results of this work are promising for further investigation and development of CTP‐SLNPs as nanomedicines for cancer.
Practical applicationsThis research presents a practical approach for utilizing the anti‐cancer benefits of natural bioactive ingredients from tea and turmeric, and has potential applications in clinical cancer therapy. The present work provides a stable CTP‐SLNPs formulation with significant anti‐cancer activity, which could be used for further development as a potential chemotherapeutic agent. The validated analytical...

Source: Journal of Food Biochemistry - October 8, 2016 Category: Food Science Authors: Rui Li, Kun Jia, Xiang ‐Gui Chen, Hong‐Tao Xiao Tags: Full Article Source Type: research