Kamada and Kedrion Seek FDA Approval of Human Rabies Immunoglobulin as a Post-Exposure Treatment
Kamada and Kedrion, collaborators on development and commercialization of post-exposure treatment for suspected rabies, announced today the filing of a BLA with the FDA On approval by FDA, the product will represent a new option in a market where supply... Biopharmaceuticals, FDA Kamada, Kedrion, rabies, KamRAB
A global coalition set up to fight disease epidemics is investing up to $8.4 million to develop a synthetic vaccine system that could be tailor-made to fight multiple pathogens such as flu, Ebola, Marburg and Rabies.
CONCLUSION:: These results confirm the recommendation by CDC and state public health laboratories that indeterminate results should be considered positive and justify the prompt treatment of exposed persons through an animal that is suspected to have rabies. PMID: 30508492 [PubMed - as supplied by publisher]
To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination.
(PLOS) Domestic dogs play a key role in the transmission and expansion of rabies in rural areas of China, according to a study published Dec. 6 in the open-access journal PLOS Pathogens by Huaiyu Tian of Beijing Normal University, Hailin Zhang of the Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Simon Dellicour of KU Leuven, and colleagues.
ConclusionsThis study established a street RABV library reflecting the epidemiological features of Chinese rabies viruses, which provides a platform for detecting the neutralizing activity of MAbs against rabies viruses circulating in China.
We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus–mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD) chemogenetic method, we demonstrated that newborn hippocampal DGCs are required for the formation of epileptic neural circuits and the induction of spontaneous recurrent seizures (SRS). A rabies virus–mediated mapping study revealed that aberrant circuit integration of hippocampal newborn DGCs formed excessive de novo excitatory connections as well as recurrent excitatory lo...
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Abstract In Madagascar, dog-mediated rabies has been endemic for over a century, however there is little data on its incidence or impact. We collected data over a 16-month period on provisioning of post-exposure prophylaxis (PEP) at a focal clinic in the Moramanga District and determined the rabies status of biting animals using clinical and laboratory diagnosis. We find that animal rabies cases are widespread, and clinic-based triage and investigation are effective ways to increase detection of rabies exposures and to rule out non-cases. A high proportion of rabies-exposed persons from Moramanga sought (84%) and ...
Publication date: Available online 27 November 2018Source: Journal of Theoretical BiologyAuthor(s): Mirjam Laager, Monique Léchenne, Kemdongarti Naissengar, Rolande Mindekem, Assandi Oussiguere, Jakob Zinsstag, Nakul ChitnisAbstractRabies transmission was interrupted for several months in N’Djamena, the capital city of Chad, after two mass vaccination campaigns of dogs. However, there was a resurgence in cases, which was not predicted by previous models of rabies transmission. We developed a deterministic metapopulation model with importation of latent dogs, calibrated to four years of weekly incidence data fr...
[Malawi News Agency] Mangochi -Mangochi District Agriculture Office has limited anti-rabies vaccine for campaigns in three hotspots namely, Monkey Bay, Malombe and Mpilipili due to inadequate resources.