Malawi: Mzuzu Add Admits Anti-Rabies Vaccine Inadequacy

[Malawi News Agency] Mzuzu -Mzuzu City residents may not have their dogs vaccinated against rabies in this year's anti-rabies month, as Mzuzu Agricultural Development Division (MZADD) says does not have sufficient vaccine for the same.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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In this study we have generated several non-conform vaccine lots by an excessive inactivation with β-propiolactone (BPL) and assessed the capacity of both tests to detect the corresponding consequences. Excessive BPL inactivation causes G-protein unfolding, altering in turn viral morphology and the continuity of the G-protein layer in the viral particle. Both the NIH and the ELISA tests were able to monitor the consequences of excessive inactivation in a similar manner. Of note, the experimental error of the ELISA test was well below that of the NIH test. These results increase the prospect that the ELISA test could b...
Source: Biologicals - Category: Biology Source Type: research
RABIES was confirmed in a steer found in Larimer County, Colorado yesterday, prompting health officials to remind pet and livestock owners to keep their animals up-to-date on vaccinations. What are the symptoms of rabies and can you get rabies from a dog bite?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 7 May 2019Source: Antiviral ResearchAuthor(s): Zoé Lama, Yves Gaudin, Danielle Blondel, Cécile Lagaudriere-GesbertAbstractRabies virus (RABV) is a neurotropic virus that causes fatal encephalitis in humans and animals and still kills up to 59,000 people worldwide every year. To date, only preventive or post-exposure vaccination protects against the disease but therapeutics are missing. After screening a library of 80 kinases inhibitors, we identified two compounds as potent inhibitors of RABV infection: Tyrphostin 9 and Rottlerin. Mechanism of action studies show that both i...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Rabies virus (RABV) is a neurotropic virus that causes fatal encephalitis in humans and animals and still kills up to 59,000 people worldwide every year. To date, only preventive or post-exposure vaccination protects against the disease but therapeutics are missing. After screening a library of 80 kinases inhibitors, we identified two compounds as potent inhibitors of RABV infection: Tyrphostin 9 and Rottlerin. Mechanism of action studies show that both inhibitors interfere with an early step of viral cycle and can prevent viral replication. In presence of Tyrphostin 9, the viral entry through endocytosis...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 30 April 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Diego Fontana, Federico Marsili, Ernesto Garay, Juan Battagliotti, Marina Etcheverrigaray, Ricardo Kratje, Claudio PrietoAbstractRabies is a neglected disease with an estimated annual mortality of 55,000 human deaths, affecting mainly low-income countries. Over 95% of these cases result from virus transmission through the bite of infected dogs and for this reason there is a real need for a cheap and effective rabies veterinary vaccine to be used in mass vaccination campaigns. In this work, we descr...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
This study not only gives us insight into the understanding of the phenotype of RABV N gene rearrangement, but also helps with rabies vaccine candidate construction.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, we standardized a real-time quantitative RT-PCR duplex assay to be used during intermediate stages of the vaccine production. This assay was done for the quantification of vaccine strain rabies virus, targeting rabies nucleoprotein, and β-actin mRNA of BHK-21 cells as an internal endogenous control. The results showed specific amplification, with the analytical sensitivity ranged from 101 to 106 TCID50/mL with high repeatability rate for the quantification of rabies virus in inactivated vaccine samples. Global organizations are engaged to develop new approaches to determine viable residual virus, and th...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
I just got an internship that requires a rabies vaccine and I know most school require it anyway. First of all how do I find out who can administer that, second how have people paid for it?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Veterinary Source Type: forums
Abstract Inactivation of rabies virus is essential for rabies vaccine preparation where the inactivating compound that is currently recommended for rabies vaccine preparation is β-propiolactone (β-PL). This compound is considered better than phenol and formalin but it is expensive and potentially carcinogenic. Data revealed that Ascorbic acid (AA) with cupric ions could yield complete and irreversible inactivation of rabies virus without adversely affecting its antigenicity. Additionally, the results of testing the vaccine potency with the selected inactivating compounds were comparable (P
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, five monoclonal antibodies (mAbs), designated 3B9, 4A1, 2B11, 2C1, and 4B11, against the RABV M protein were generated using a recombinant M protein. All five mAbs reacted with the CVS-11 strain but showed no reactivity against the HEP-Flury strain in indirect immunofluorescence and western blotting. The epitope targeted by these mAbs was further identified by peptide scanning using GST-fused peptides. The 25PPYDDD30 peptide was defined as the minimal linear epitope. Alignment of amino acid sequences and phylogenetic analysis of different RABV strains indicated that the variable epitope 25PPDGDD30 is only pr...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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