Concomitant Infection of HIV and HPV: What Are the Consequences?

Abstract
Data support the impact of antiretroviral therapy (ART) on the burden of cervical HPV and related lesions. ART is effective at reducing the prevalence and incidence of high-risk (HR)-HPV infection but only over longer duration, and among patients with effective ART (i.e. with high adherence, HIV viral suppression and increasing CD4+ T lymphocyte counts). ART has a protective effect against squamous intraepithelial lesion (SIL) incidence and progression and induces regression with the greatest likelihood among adherent users. ART initiated at high CD4+ is effective at preventing HR-HPV infection and SIL progression. If ART is started at a low nadir CD4+, women have increased risk of SIL progression and screening will be important at frequent intervals.

Source: Current Obstetrics and Gynecology Reports - September 26, 2015 Category: OBGYN Source Type: research