Alopecia sufferer embraces going bald after her hair fell out
Sian Pennant-Jones, 18, from Portishead, north Somerset, was diagnosed with alopecia totalis and feared she would have to give up her dream career as a dancer, but now loves changing her hair colour to suit her mood.
Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis Interventions: Drug: Fecal material transfer therapy; Procedure: 4mm Punch Biopsy of Scalp; Diagnostic Test: Blood draw; Procedure: Skin Microbiome sampling; Procedure: Hair Microbiome Sampling; Drug: Pre-FMT Antibiotic Cocktail; Drug: Bowel Prep Sponsor: Columbia University Not yet recruiting
Isolated complex III (CIII) deficiencies are among the least frequently diagnosed mitochondrial disorders. Clinical symptoms range from isolated myopathy to severe multi-systemic disorders with early death and disability. To date, we know of pathogenic variants in genes encoding five out of 10 subunits and five out of 13 assembly factors of CIII. Here we describe rare bi-allelic variants in the gene of a catalytic subunit of CIII, UQCRFS1, which encodes the Rieske iron-sulfur protein, in two unrelated individuals.
Conclusions There was a significant relation between the severity of alopecia and treatment outcome. (p=0.038) Patients with alopecia areata had significantly better response when compared to alopecia totalis and universalis. There was no statistically significant relation with other parameters such as disease duration, age, gender, atopy history, age of onset, and histopathological features. PMID: 31655499 [PubMed - as supplied by publisher]
In this study, we report an Iranian patient who presented with Addison disease, chronic mucocutaneous candidiasis, alopecia totalis, keratopathy and asplenia treated as an isolated endocrinopathy for 25 years. In the adulthood, the diagnosis of APECED was made by genetic analysis which demonstrated homozygous nonsense p.R257* (c.769C>T) mutation of AIRE. APECED has been shown to be frequent in some ethnicities including Iranian Jews. Therefore, we reviewed 39 Iranian APECED patients published in the literature. We found that most of the Iranian patients were of Jewish ethnic background and presented hypoparathyroidism, ...
Background: Alopecia areata (AA) is a chronic disorder characterized by patchy loss of hair. Sometimes disease can be severe leading to loss of entire scalp and body hair. Management of these patients is very difficult with the available options of topical and systemic immunosuppressant agents. Tofacitinib, JAK3 inhibitor, is emerging as a promising drug for the management of severe and resistant cases of AA/totalis/universalis.
Alopecia areata (AA) is a common autoimmune alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about AA epidemiology.
Alopecia areata (AA) is a common, autoimmune, alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about AA epidemiology.
Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis Intervention: Combination Product: Stem Cell Educator therapy combined with minoxidil Sponsors: Tianhe Stem Cell Biotechnologies Inc.; Yale University; Hackensack Meridian Health Not yet recruiting