Compartmental anisotropy of filtered exchange imaging (FEXI) in human white matter: What is happening in FEXI?

CONCLUSION: Orientation-dependent AXR and σ values were observed when using multi-orientation filter and detection gradients in FEXI, indicating that WM FEXI models need to account for compartmental anisotropy. When using trace-weighted detection, AXR values were on the order of or less than R1, complicating the interpretation of FEXI results in WM in terms of biological exchange properties. These findings may contribute toward better understanding of FEXI results in WM.PMID:38525601 | DOI:10.1002/mrm.30086

Source: Magnetic Resonance in Medicine - March 25, 2024 Category: Radiology Authors: Hyeong-Geol Shin Xu Li Hye-Young Heo Linda Knutsson Filip Szczepankiewicz Markus Nilsson Peter C M van Zijl Source Type: research