Dynamic intervention strategies await inclusion in clinical evidence synthesis

In the first half of this year, an article about the next generation of evidence-based medicine1 was published in Nature Medicine, emphasising the growing significance of real-world data in future evidence-based practice and research, providing an opportunity for the evidence accumulation of dynamic intervention (DI) strategies (spanning sequential designs to real-time feedback protocols) in various diseases, as is patient-centric, adaptable and pivotal for modern patient care. Most intervention meta-analyses address static interventions, diverging from dynamic clinical practices in multistage diseases such as the facial neuritis, primarily comparing positive interventions to controls or other therapies, overlooking real-world adaptive strategies used at different disease stages. For facial neuritis, the early stage may benefit more from gentle acupuncture and concurrent steroid use to relieve inflammation and compression; as condition stabilises, enhanced acupuncture and targeted neural reconstruction methods may be more appropriate than identical acupuncture parameters, consistent steroid use or...

Source: Evidence-Based Medicine - March 21, 2024 Category: Internal Medicine Authors: Pan, T., Zhang, P. Tags: Correspondence Source Type: research