Multi-centre evaluation of variation in cumulative dose assessment in reirradiation scenarios

Reirradiation with curative intent is increasing in frequency due to improvements in patient outcomes and availability of modern precision radiotherapy techniques, such as image guidance and dose sculpting capabilities [1]. Safe reirradiation requires reliable assessment of cumulative doses to critical organs, contending with anatomical changes between treatment courses and radiobiological effects from fraction size and tissue recovery [2]. Retrospective evaluations of reirradiation clinical outcomes that include assessment of cumulative doses have been reported for a range of tumour sites [3 –11].

Source: Radiotherapy and Oncology - March 5, 2024 Category: Radiology Authors: Nicholas Hardcastle, Eliana Vasquez Osorio, Andrew Jackson, Charles Mayo, Anja Eineb ærholm Aarberg, Myriam Ayadi, Francesca Belosi, Cemile Ceylan, Angela Davey, Pauline Dupuis, Julia-Claire Handley, Theresa Hemminger, Lone Hoffmann, Colin Kelly, Chrysan Tags: Original Article Source Type: research