An industry perspective approach and control strategy for implementation of ready-to-use cells in bioassays: survey outcome and recommendations

Biotechniques. 2024 Feb 9. doi: 10.2144/btn-2023-0086. Online ahead of print.ABSTRACTThe BioPhorum Development Group is an industry collaboration enabling the sharing of common practices for the development of biopharmaceuticals. Bioassays are an important part of an analytical control system. Utilization of ready-to-use cells can increase operational flexibility and improve efficiency by providing frozen cell banks uniform stock while removing challenges associated with maintaining cultured cells. The BioPhorum Development Group-Bioassay workstream conducted an intercompany benchmarking survey and group discussions around the use of ready-to-use cells for bioassays. The results of the collaboration provide alignment on nomenclature, production, qualification and implementation of ready-to-use cells to support the assay life cycle.PMID:38334496 | DOI:10.2144/btn-2023-0086

Source: BioTechniques - February 9, 2024 Category: Biotechnology Authors: John R White Sammina Ahmed Jan Amstrup Petra Bennington Zhijie Jey Cheng Peter Day Keneshia K Haenssen Adi Kozminsky-Atias Eva Martinez Esther Hq Ong Isam Qahwash Elaine Se Stokes Jenny Wang Source Type: research