Feasibility of using bacteriophage therapy to treat Staphylococcal aureus fracture-relatedinfections

Fracture-related infections (FRIs) are one of the most challenging complications of fracture fixation surgery resulting in additional unplanned surgical interventions, increased loss of productivity, prolonged morbidity, and functional compromise [1]. Unfortunately, treatment failure occurs in approximately 25% –40% of cases [2–5]. The main reason for the unacceptably high failure rates is the propensity of FRI pathogens to form biofilms on the implants, bone and soft tissue surrounding the fracture [6,7].

Source: Injury - February 17, 2024 Category: Orthopaedics Authors: James B. Doub, Ashley E. Levak, Lauren Sands, Joseph Blommer, Joseph Fackler, Robert V. O'Toole Source Type: research