Dupilumab for the Treatment of Prurigo Nodularis

Skin Therapy Lett. 2023 Nov;28(6):7-9.ABSTRACTPrurigo nodularis (PN) is a chronic inflammatory skin condition characterized by the presence of pruritic nodules. Dupilumab was approved by the US Food and Drug Administration in September 2022 and Health Canada in July 2023 for the treatment of PN. Dupilumab is a human monoclonal immunoglobulin G4 antibody that binds the interleukin (IL)-4 receptor alpha subunit, blocking intercellular signalling of IL-4 and IL-13. Inhibition of these cytokines downregulates the inflammatory response and improves disease severity and pruritus. Two randomized controlled trials have shown dupilumab to be effective in reducing pruritus and lesion count in patients with PN. The approval of dupilumab for PN represents the first approved therapy for PN and may indicate a paradigm shift in the way this condition is treated.PMID:38016088

Source: Skin Therapy Letter - November 28, 2023 Category: Dermatology Authors: Ayaa Alkhaleefa Taylor Evart Woo Laurie Parsons Source Type: research