NLRP3-mediated periodontal ligament cell pyroptosis promotes root resorption

CONCLUSIONS: NLRP3-mediated PDLC pyroptosis promotes RR. PDLCs transmit excessive force into inflammation signals through TLR4/NFκB/NLRP3 pathway, inducing PDLC pyroptosis, which directly promotes odontoclast formation and subsequent RR or promotes M1 polarization to indirectly trigger odontoclastogenesis and RR.PMID:38164052 | DOI:10.1111/jcpe.13914

Source: Journal of Clinical Periodontology - January 2, 2024 Category: Dentistry Authors: Xinyi Li Xinrui Men Ling Ji Xinyi Chen Shushu He Ping Zhang Song Chen Source Type: research