Molecular Organization of the Skin Barrier

Acta Derm Venereol. 2023 Nov 21;103:adv13356. doi: 10.2340/actadv.v103.13356.ABSTRACTCryo-electron microscopy of vitreous sections allows for investigation directly in situ of the molecular architecture of skin. Recently, this technique has contributed to the elucidation of the molecular organization of the skin's permeability barrier and its stepwise formation process. The aim of this review is to provide an overview of the procedure for cryo-electron microscopy of vitreous sections, its analysis using atomic detail molecular dynamics modelling and electron microscopy simulation, and its application in the investigation of the barrier structure and formation process of the skin.PMID:37987626 | DOI:10.2340/actadv.v103.13356

Source: Acta Derm Venereol A... - November 21, 2023 Category: Dermatology Authors: Lars Norl én Source Type: research