The metabolic control theory: Its development and its application to mitochondrial oxidative phosphorylation

Biosystems. 2023 Oct 12:105038. doi: 10.1016/j.biosystems.2023.105038. Online ahead of print.ABSTRACTMetabolic Control Theory (MCT) and Metabolic Control Analysis (MCA) are the two sides, theoretical and experimental, of the measurement of the sensitivity of metabolic networks in the vicinity of a steady state. We will describe the birth and the development of this theory from the first analyses of linear pathways up to a global mathematical theory applicable to any metabolic network. We will describe how the theory, given the global nature of mitochondrial oxidative phosphorylation, solved the problem of what controls mitochondrial ATP synthesis and then how it led to a better understanding of the differential tissue expression of human mitochondrial pathologies and of the heteroplasmy of mitochondrial DNA, leading to the concept of the threshold effect.PMID:37838015 | DOI:10.1016/j.biosystems.2023.105038

Source: Biosystems - October 14, 2023 Category: Biotechnology Authors: Jean-Pierre Mazat Source Type: research