Noninvasive Evaluation of Fetal Zygosity in Twin Pregnancies Involving a Binary Analysis of Single-Nucleotide Polymorphisms
Twin pregnancy constitutes significant risks for maternal and fetal health, which is usually detected by ultrasound examination at early gestation. However, the imaging-based approach may not accurately identify all twins confounded by practical or clinical variables. The analysis of fetal cell-free DNA in noninvasive prenatal screening assays can completement the ultrasound method for twin detection, which differentiates fraternal or identical twins based on their distinct genotypes. Here, a new noninvasive prenatal screening employing high-coverage next-generation sequencing for targeted nucleotide polymorphisms was developed for detection of zygosity and determination of fetal fraction in twin pregnancies.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Yanlin Wang, Xiang Qiu, Songchang Chen, Dong Pan, Renyi Hua, Shuyuan Li, Yiyao Chen, Nina Pan, Xiaoqiang Cai, Jianli Li, Xin Zhao, Jing Wang, Ruilin Jing, Guangxin Xiang, Zhiwei Zhang, He-Feng Huang, Chenming Xu, Jinglan Zhang Tags: Regular article Source Type: research