Interaction between apical periodontitis and systemic disease (Review)
Int J Mol Med.2023 Jul;52(1):60.
doi: 10.3892/ijmm.2023.5263.
Epub 2023 Jun 2.
Abstract
Apical periodontitis is an oral common inflammatory disease
initiated by infection of pulp chamber and is characterized by
destruction and resorption of the periapical bone. As a local infection,
pathogens and their products in periapical tissues, as well as
inflammatory cytokines produced in periapical lesions, enter the blood
circulation, triggering systemic immune responses and leading to the
pathogenesis of various types of systemic disease. Therefore, apical
periodontitis might be associated with systemic disease rather than
solely simple local oral disease. In addition, the existence of a
hyperinflammatory state in certain patients with chronic
inflammation ‑related disorder may affect the progression or prognosis of
apical periodontitis. However, the association and potential mechanisms
between apical periodontitis and systemic diseases remain unclear. An
in‑depth understanding of the association between apical periodontitis
and systemic disea se will be useful for both dentists and physicians to
eliminate the possible risk factors and promote the healing of apical
periodontitis and systemic disease. Thus, the aim of the present review
is to introduce the potential relationship between apical periodontitis
and systemic disease.
Source: Dental Technology Blog - Category: Dentistry Source Type: news