Acute Attenuation of Motor Impairments With a Noradrenergic Pharmacological Agent in Chronic Hemiparetic Stroke

To investigate the dependence of stroke-induced loss of independent joint control and spinal motoneuron excitability on noradrenergic drive. Chronic stroke-induced limitations in upper extremity motor function commonly manifest as a loss of independent joint control and augmented spinal motoneuron excitability, with accumulating evidence attributing these findings to increased monoaminergic (norepinephrine) drive and greater reliance on contralesional corticoreticulospinal tracts.

Source: Archives of Physical Medicine and Rehabilitation - December 1, 2022 Category: Rehabilitation Authors: James Beauchamp, Sebastian Urday, Thomas Plaisier, CJ Heckman, Julius Dewald Tags: Research Poster 2184322 Source Type: research