33635 Recalcitrant bullous rash presenting in a pediatric patient, ultimately responsive to dupilimab

A 17-year-old female reported a pruritic blister on the left breast 2 months prior to presentation. Within a month she noticed vesicles on the inner legs. Her primary care physician prescribed doxycycline for possible impetigo. The lesions continued to spread so she was referred to dermatology. On examination, there were multiple tense bullae symmetrically distributed on the face, trunk, and extremities. There was a single erosion of the hard palate and excoriated vesicles of the labia majora. A biopsy showed a subepidermal split with a predominance of neutrophils and eosinophils.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research