Partial response to erlotinib in a patient with imatinib-refractory sacral chordoma
ConclusionsAs seen in previously reported cases, erlotinib is a therapeutic option in advanced chordoma, even in imatinib refractory cases and thus warrants exploration of its therapeutic role in prospective clinical trials. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 12, 2020 Category: Cancer & Oncology Source Type: research
Locally recurrent extraskeletal myxoid chondrosarcoma of the shoulder: a case of complete neoadjuvant radiotherapy response
ConclusionsThe case here described suggests the importance of patient ’s management in SRCs. A planned combined treatments with both surgery and RT seems to be the best choice to improve local control. RT seems to be promising within this specific histotype. Further studies are needed to confirm if the observed efficacy of combined treatments reflects in a consisten t survival benefit for EMC patients. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 11, 2020 Category: Cancer & Oncology Source Type: research
The role of prognostic nutritional index in the management of pulmonary sarcomatoid carcinoma
ConclusionThe PNI and the pathological TNM stage are independent prognostic factors for pulmonary sarcomatoid carcinoma. PNI is an important indicator for the selection of postoperative adjuvant therapy. Patients with PNI ≥ 49.4 may benefit from postoperative chemotherapy and targeted therapy. We still need further prospective studies to confirm these results. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - December 7, 2020 Category: Cancer & Oncology Source Type: research
Ifosfamide-induced encephalopathy: the EEG with frontal intermittent delta activity, and rapid resolution with methylene blue: A case report
ConclusionThe rapid resolution of the encephalopathy on the EEG after administration of methylene blue adds further evidence to its effectiveness as a treatment for the disorder. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 28, 2020 Category: Cancer & Oncology Source Type: research
Simultaneous diagnosis of liver PEComa in a family with known Li –Fraumeni syndrome: a case report
ConclusionsThe simultaneous diagnosis of PEComa in two siblings presented in this case allowed us to review the frequency of PEComa in this genetic syndrome previously reported, which was very little. Despite its rarity, PEComa must be considered in the differential diagnosis of new-onset liver lesions in patients who were previously diagnosed with LFS. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 24, 2020 Category: Cancer & Oncology Source Type: research
Solitary extrapleural fibrous tumor with hepatic bilobar metastases: multimodal approach treatment
ConclusionSolitary fibrous tumours with extensive liver metastases are infrequent but when they appear modern surgical strategies like two stage hepatectomy are the treatment of choice and must be carried out by specialised units. The therapeutic decisions should be guided by a multidisciplinary committee. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 18, 2020 Category: Cancer & Oncology Source Type: research
Preoperative accelerated radiotherapy combined with chemotherapy in a defined cohort of patients with high risk soft tissue sarcoma: a Scandinavian Sarcoma Group study
ConclusionsPreoperative chemotherapy and radiotherapy were associated with temporary wound-healing problems. Survival outcomes, local control and toxicities were deemed satisfactory when considering the locally advanced sarcoma disease status at primary diagnosis.Trial registration This study was registered at ClinicalTrials.gov Identifier NCT00790244 and with European Union Drug Regulating Authorities Clinical Trials No. EUDRACT 2007-001152-39 (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 17, 2020 Category: Cancer & Oncology Source Type: research
Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma
ConclusionThis has demonstrated that there is an international consensus around many aspects of the local treatment of Ewing sarcoma of bone, including the use of specialist MultiDisciplinary Team (MDT) meetings with access to all appropriate treatments. However, considerable variation remains including the use of different staging investigations, decision making, definitions of response, and radiotherapy doses and timing. Further collaborative work should be undertaken to determine the impact of these variations in order to define best practice. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - November 17, 2020 Category: Cancer & Oncology Source Type: research
Glomus tumors with malignant features of the extremities: a case series
ConclusionsOur study supports the current literature that wide-local resection with the goal of negative margins is still the current gold standard treatment for glomus tumors with malignant features. Studies with larger cohorts are necessary before recommending for or against radiotherapy or chemotherapy. Early biopsy and referral to a tertiary sarcoma center prior to surgical resection may help reduce the re-resection rate and potential seeding of the tumor in these patients, thereby improving outcomes. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - October 30, 2020 Category: Cancer & Oncology Source Type: research
When does a new sarcoma exist?
(Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - September 12, 2020 Category: Cancer & Oncology Source Type: research
Survival of soft tissue sarcoma patients after completing six cycles of first-line anthracycline containing treatment: an EORTC-STBSG database study
ConclusionThis large retrospective study is the first to report progression free survival and overall survival after completion of 6 cycles of first line doxorubicin containing chemotherapy. These results are important when designing new studies exploring for example maintenance therapy after doxorubicin based chemotherapy. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - September 8, 2020 Category: Cancer & Oncology Source Type: research
Anthracycline-based and gemcitabine-based chemotherapy in the adjuvant setting for stage I uterine leiomyosarcoma: a retrospective analysis at two reference centers
ConclusionsDFS was not the same by using an anthracycline-based or a gemcitabine-based adjuvant chemotherapy for patients with radically resected eULMS. The results of our study are in line with recent prospective controlled evidence in limb and superficial trunk soft tissue sarcomas. The role of anthracycline-based adjuvant chemotherapy should still be viewed as a research issue in eULMS. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - August 27, 2020 Category: Cancer & Oncology Source Type: research
Long lasting response with trabectedin monotherapy in relapsed metastatic mesenchymal chondrosarcoma
ConclusionThis report aims to present a comprehensive review into available and newer treatment choices for mesenchymal chondrosarcoma, and to highlight trabectedin monotherapy as a possible therapeutic option for mesenchymal chondrosarcoma in the relapsed setting. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - August 26, 2020 Category: Cancer & Oncology Source Type: research
Paraneoplastic dermatomyositis associated with metastatic leiomyosarcoma of unknown primary
DiscussionParaneoplastic dermatomyositis heralded disease progression after first-line chemotherapy; however, in hindsight, subtle cutaneous features were present at sarcoma diagnosis. The temporal relationship between paraneoplastic dermatomyositis and metastatic leiomyosarcoma is key in this case, as fluctuations in dermatomyositis severity correlated with growth of metastatic disease. Understanding this relationship may provide clues for tumour progression and prompt timely initiation of anti-cancer therapy. It is important to recognise that in addition to the more common cancers associated with paraneoplastic dermatomy...
Source: Clinical Sarcoma Research - August 24, 2020 Category: Cancer & Oncology Source Type: research
Treatment of gastrointestinal tumor (GIST) of the rectum requiring abdominoperineal resection following neoadjuvant imatinib: a cost-effectiveness analysis
ConclusionUAPR is more effective and less costly than CIUP for patients with rectal GIST requiring abdominoperineal resection following neoadjuvant imatinib, and is the strategy of choice in this setting. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - August 5, 2020 Category: Cancer & Oncology Source Type: research
