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Metabolically healthy obesity: facts and fantasies
Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered “metabolically healthy.” However, there is no universally accepted definition of metabolically healthy obesity (MHO). Most studies define MHO as having either 0, 1, or 2 metabolic syndrome components, whereas many others define MHO using the homeostasis model assessment of insulin resistance (HOMA-IR). Therefore, numerous people reported as having MHO are not metabolically healthy, but simply have fewer m...
Source: Journal of Clinical Investigation - September 17, 2019 Category: Biomedical Science Authors: Gordon I. Smith, Bettina Mittendorfer, Samuel Klein Source Type: research

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Parkinson’s disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enhances the activity of phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis and increasing cellular ATP levels. Therefore, we asked whether enhancement of PGK1 activity would change the course of PD. In toxin-induced and genetic PD models in mice, rats, flies, and induced pluripotent stem cells, TZ increased brain ATP levels and slowed or prevented neuron loss. T...
Source: Journal of Clinical Investigation - September 17, 2019 Category: Biomedical Science Authors: Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunmi Source Type: research

IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
In conclusion, IL-1α and IL-1β are upstream components of a signaling pathway, including IL-1R1 and downstream SPDEF and ERN2, that generate a positive feedback cycle capable of producing persistent mucus hyperconcentration and IL-1α and/or IL-1β–mediated neutrophilic inflammation in the absence of infection in CF airways. Targeting this pathway therapeutically may ameliorate mucus obstruction and inflammation-induced structural damage in young CF children.
Source: Journal of Clinical Investigation - September 17, 2019 Category: Biomedical Science Authors: Gang Chen, Ling Sun, Takafumi Kato, Kenichi Okuda, Mary B. Martino, Aiman Abzhanova, Jennifer M. Lin, Rodney C. Gilmore, Bethany D. Batson, Yvonne K. O’Neal, Allison S. Volmer, Hong Dang, Yangmei Deng, Scott H. Randell, Brian Button, Alessandra Livraghi Source Type: research

Revealing the molecular signaling pathways of mucus stasis in cystic fibrosis
Mucus obstruction is a hallmark of cystic fibrosis (CF) airway disease, leading to chronic infection, dysregulated inflammation, and progressive lung disease. As mucus hyperexpression is a key component in the initiation and perpetuation of airway obstruction, the triggers underlying mucin release must be identified and understood. In this issue of the JCI, Chen et al. sought to delineate the mechanisms that allow IL-1α/IL-1β to perpetuate the mucoinflammatory environment characteristic of the CF airway. The authors demonstrated that IL-1α and IL-1β stimulated non-CF human bronchial epithelial (HBE) cells to upregulate...
Source: Journal of Clinical Investigation - September 17, 2019 Category: Biomedical Science Authors: Susan E. Birket, Steven M. Rowe Source Type: research

Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome
The prognostic value of immune cell infiltration within the tumor microenvironment (TME) has been extensively investigated via histological and genomic approaches. Based on the positive prognostic value of T cell infiltration, Immunoscore has been developed and validated for predicting risk of recurrence for colorectal cancer (CRC). Also, association between a consensus T helper 1 (Th-1) immune response and favorable clinical outcomes has been observed across multiple cancer types. Here, we reanalyzed public genomic data sets from The Cancer Genome Atlas (TCGA) and NCBI Gene Expression Omnibus (NCBI-GEO) and performed mult...
Source: Journal of Clinical Investigation - September 17, 2019 Category: Biomedical Science Authors: Marwan Fakih, Ching Ouyang, Chongkai Wang, Travis Yiwey Tu, Maricel C. Gozo, May Cho, Marvin Sy, Jeffrey A. Longmate, Peter P. Lee Source Type: research

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations
ConclusionsSLMP53-1 is a p53-activating agent with the ability to directly target wt and a set of hotspot mutp53.General SignificanceThis work reinforces the encouraging application of SLMP53-1 in the personalized treatment of cancer patients harboring distinct p53 status.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - September 17, 2019 Category: Biochemistry Source Type: research

Three Different Types of Activated Carbon and Manganese-Modified Activated Carbons as Deoxidizers for the Low-Concentration Coalbed Methane Deoxidation
Different activated carbons and manganese-modified activated carbons were prepared as deoxidizers for the low-concentration coalbed methane deoxidation. The results show that the deoxidation performance of the different activated carbons is affected by raw materials for preparation of deoxidizers. One type of activated carbon exhibited the best performance of oxygen removal, due to the relatively low ash content and better adsorption performance. Experimental results show that the manganese-modified deoxidizers exhibit an excellent deoxidation efficiency at low temperature. At 200 ºC, one kind of manganese-modified activa...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Release Behavior of Arsenic during Pyrolysis of Two Chinese Coal Gangues
Release behaviors of arsenic (As) during pyrolysis of two Chinese coal gangues were studied in this report. The pyrolysis experiments were carried out in a temperature programmed tube furnace under N2 atmosphere with different temperature (200-1200 ºC), residence time (0-50 min), heating rate (10-50 ºC min-1) and N2 gas flow rate (100-500 cm3 min-1). The experiment results, under different pyrolysis conditions, indicate that the release ratio of As increases with increasing temperature, as well as residence time during pyrolysis of coal gang ues. Besides that, higher heating rate during pyrolysis of coal gangues can stim...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Layered Double Hydroxides with the Composition Mn/Al-SO4-A (A = Li, Na, K; Mn:Al ca. 1:1) as Cation Exchangers
Hydrated Mn/Al-SO4-A (A = Li, Na or K) layered double hydroxides with M2+:M3+ molar ratio close to 1:1 were synthesized by co-precipitation with increasing pH. All phases presented solvated alkali metals and sulfate as intercalated species. In the exchange reactions, when sulfate solutions of alkali metals were used, sodium could be partially replaced by potassium, and the same was true for the potassium phase, where potassium could be partially replaced by Na and Li, without removing the intercalated sulfate anions. This class of compounds, considered to be anion exchanger, can also exchange cations, which opens new persp...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Rapid and Effective Sample Cleanup based on Polyvinylpyrrolidone-Coated Magnetite Nanoparticles Coupled with New Pre-Column Derivatization for Determination of Aflatoxins B1, B2, G1 and G2 in Animal Feeds by High-Performance Liquid Chromatography with Fluorescence Detection
A novel method for the determination of aflatoxins B1, B2, G1, and G2 (AFB1, AFB2, AFG1, AFG2) in animal feed samples based on magnetic solid-phase cleanup and novel pre-column derivatization has been developed. In this work, synthesized polyvinylpyrrolidone-coated Fe3O4 magnetic nanoparticles were applied as adsorbents for rapid cleanup for extracts of animal feed samples. The purified extract was then derivatized with trifluoroacetic acid coupling ultraviolet irradiation which enabled the weakly fluorescent AFB1 and AFG1 transformed into their highly fluorescent hemiacetals derivatives. Afterward aflatoxins were separate...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Imidazo1,2-apyridine A3-Coupling Catalyzed by a Cu/SiO2 Material
In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A3-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%), which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of rea...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Dithiocarbamate Residues in Fruits and Leaves of Passion Fruit (Passiflora edulis) from Different Brazilian Regions
In this study, the spectrophotometric method for determination of dithiocarbamate residues, as CS2, in passion fruit (Passiflora edulis) was validated at a limit of quantification (LOQ) of 0.05 mg kg-1 CS2, and 108 samples (55 fruits and 53 leaves) collected from Brazilian growers were analyzed. About 25% of the fruit peel samples were positive (0.06 to 1.4 mg kg-1) and only one sample had residues in the pulp (0.09 mg kg-1), 43.4% of leaf samples contained residues. Washing of fruit reduced the residues in the peel by up to 100%, and drying the leaves increased residue levels by up to 60%. This is the first study that rep...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Molecular Diagnostics of Dengue by Reverse Transcription-Loop Mediated Isothermal Amplification (RT-LAMP) in Disposable Polyester-Toner Microdevices
Dengue is one of the most prevalent infectious tropical diseases in the world, with high incidence in over 100 countries. Rapid and reliable diagnosis of dengue is of great importance for public health. To simplify molecular diagnostics, isothermal amplification techniques have recently emerged as an alternative to conventional methods of deoxyribonucleic acid (DNA) amplification. Here, we developed a one-step method for dengue virus detection from real sample based on RT-LAMP (reverse transcription-loop mediated isothermal amplification) in a disposable microdevice. The reaction was thermally controlled with a thermoblock...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Chemosensor Development of Cu2+ Recognition Using 1,5-Diphenylthiocarbazone: Optimization, COSMO-RS and DFT Studies
The sensitive and selective chemosensor for copper(II) ions (Cu2+) was successfully optimized using the 1,5-diphenylthiocarbazone (DPT) compound. The result showed that dimethyl sulfoxide (DMSO) in a 9:1 (DMSO:water) ratio at a pH of 3 was the optimum medium for DPT to act as chemosensor of Cu2+ recognition. The DPT chemosensor did not encounter any interference from other metal ions, including Fe3+, Ag+, Cr3+, Pb2+, Mg2+, Cd2+, Zn2+, K+, Ni2+ and Co2+. The presence of Cu2+ led to an absorption peak at 658 nm, where the color changed from cantaloupe to gray-green color indicating the interaction by the formation of the DPT...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Synthesis, Molecular Modelling and Anticancer Activities of New Molecular Hybrids Containing 1,4-Naphthoquinone, 7-Chloroquinoline, 1,3,5-Triazine and Morpholine Cores as PI3K and AMPK Inhibitors in the Metastatic Melanoma Cells
Three molecular hybrids containing 1,4-naphthoquinones, 1,3,5-triazines, morpholine and 7-chloroquinoline, which have recognized contributions to the biological activity of many drugs, were synthesized in yields ranging from 43-84%. All hybrids were obtained in three steps starting from readily available reactants: lawsone, cyanuric chloride, morpholine and 4,7-dichloroquinoline. A previous docking study was carried out to identify the binding energy and pharmacophore conformation of the promising anticancer compounds with PI3K γ (phosphoinositide 3-kinase) and AMPK (5 ’ AMP-activated protein kinase). The cancer activit...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples
A dipyridamole (DIP) based surface molecularly imprinted polymer (MIP) was synthesized and applied as a sensing agent in a sensing layer of a new modified potentiometric carbon paste electrode (CPE). The potentiometric modified CPEs (GO@SiO2-NH2-MIP/MWCNTs/CPE, where GO is graphene oxide and MWCNTs is multi-walled carbon nanotubes) showed an improved performance in term of Nernstian slope, selectivity and response time compared to the unmodified CPE. The response time of the sensor in the range of 2.5 × 10-8-1.1 × 10-2 M DIP was 20 s. The obtained DIP sensor showed low limit of detection (1 × 10-8 M), and satisfactory l...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Benzodioxol Group Driving Supramolecular Arrangement of Two Tri-Methoxy Chalcones onto Β-Secretase 1 Enzyme Active Site
Chalcones are compounds with wide interesting biological activities including Alzheimer ’ s disease. A comparative study was performed between the chalcones (E)-1-(2-aminophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one and 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one regarding the influence of benzodioxol group on their molecular conformations. The first chalcone was neutralized with dilute hydrochloric acid, while solid of the second was filtered and recrystallized from ethanol, both on centrosymmetric space group P21/c. Their molecular packing were evaluated by Hirshfeld surfaces, and bo...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor
In this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 100 mV and a 5-fold current increase for the electrochemical oxidation of ciprofloxacin, which resulted in a highly sensitive sensor, when compared to unmodified electrode. The improved properties of the modified electrode are likely due to the formation of a porous surfa...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Hydrogen Peroxide Electrogeneration by Gas Diffusion Electrode Modified With Tungsten Oxide Nanoparticles for Degradation of Orange II and Sunset Yellow FCF Azo Dyes
In this work, the gas diffusion electrode (GDE) cathode of Vulcan XC72 carbon modified with nanoparticles of WO2.72 (WO2.72 / Vulcan XC72) was used for H2O2 electrogeneration and degradation of 350 mL of Orange II (OII) and Sunset Yellow FCF (SY) azo dyes by electro-Fenton (EF) and photoelectro-Fenton (PEF) processes with different Fe2+ initial content (1.00, 0.50 and 0.25 mmol L-1). The WO2.72 / Vulcan XC72 GDE electrolyzed approximately 3 times more H2O2 than the Vulcan XC72 GDE. Decolorizations and mineralizations of the dye solutions were more efficient at higher concentrations of Fe2+. The decolorization decay showed ...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

A non-fullerene acceptor based on alkylphenyl substituted benzodithiophene for high efficiency polymer solar cells with a small voltage loss and excellent stability
J. Mater. Chem. A, 2019, Accepted Manuscript DOI: 10.1039/C9TA08636F, PaperQing Guo, Xiaoqian Zhu, Xingliang Dong, Qinglian Zhu, Jin Fang, Xia Guo, Wei Ma, Maojie Zhang, Yongfang Li In this work, a new non-fullerene small molecule acceptor (NF-SMA) named BP-4F, based on benzo[1,2-b:4,5-b ’]di(cyclopenta[2,1-b:3,4-b’]dithiophene) with 4-(2-ethylhexyl)phenyl conjugated side chains (BDT-P) as an electron-donating core, flanked with the strong electron-withdrawing... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - September 17, 2019 Category: Chemistry Authors: Qing Guo Source Type: research

A unique formyl iodoargentate exhibiting luminescent and photocurrent response properties
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT02828E, CommunicationLili Yang, Jian Zhou, Litao An, Shumei Cao Cao, Jun Hu A decomposition and self-assembly reaction affords a novel formyl iodoargentate [H2L]n[Ag2I3( µ-CHO)]n (1, L = 2,6-bis(1-imdazoly)pyridine) with an unprecedented CHO- link mode, which provides the only example of iodoargentate incorporating the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - September 17, 2019 Category: Chemistry Authors: Lili Yang Source Type: research

Home care: care profile of a service linked to a teaching hospital
Conclusion: Functions, responsibilities, costs and expenses are transferred to families, burdening home care.
Source: Physis: Revista de Saude Coletiva - September 17, 2019 Category: International Medicine & Public Health Source Type: research

The work in the management of mental health substitutive services: between Collective Health, Mental Health and Psychoanalysis
The objective is to investigate the interrelationships between the fields of Collective Health, Mental Health and Psychoanalysis in the management of mental health services in the context of the Unified Health System. This is a qualitative research carried out in four municipalities of the state of Rio Grande do Sul, Brazil, with six managers of mental health services identified with psychoanalysis. The instruments of data collection employed were a personal and sociodemographic data sheet and a semi-structured interview. Thematic analysis was used to analyze the data, resulting in the identification of three central theme...
Source: Physis: Revista de Saude Coletiva - September 17, 2019 Category: International Medicine & Public Health Source Type: research

Association between Lifelong Physical Activity and Disease Characteristics in HCM
Conclusions Lifelong physical activity volumes are not associated with genotype-to-phenotype transition in HCM gene carriers. We also found no difference in LV wall thickness across physical activity tertiles. However, the most active HCM patients were younger at the time of diagnosis and had a higher arrhythmic burden. These observations warrant further exploration of the role of exercise in HCM disease development.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research

Endurance Exercise Prevents Metabolic Distress–induced Senescence in the Hippocampus
Conclusion Our study provides novel evidence that EXE-induced antisenescence against metabolic distress in the hippocampus may be a key neuroprotective mechanism, preventing neuroinflammation and oxidative stress.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research

Low Stroke Volume during Exercise with Hot Skin Is Due to Elevated Heart Rate
Conclusions The increase in HR rather than an increase in CBF or forearm venous volume was responsible for the decrease in SV during moderate-intensity exercise when Tsk was held at 38°C.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research

Change in Physical Activity and Cardiac Structure over 10 Years: The Multi-Ethnic Study of Atherosclerosis
Conclusions After accounting for baseline PA, greater positive changes in leisure-time PA levels were associated with a more eccentric-type of LV remodeling pattern over 10 yr. The clinical implications of such findings remain to be determined.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research

Protein Supplementation Does Not Augment Adaptations to Endurance Exercise Training
Introduction Recently, it has been speculated that protein supplementation may further augment the adaptations to chronic endurance exercise training. We assessed the effect of protein supplementation during chronic endurance exercise training on whole-body oxidative capacity (V˙O2max) and endurance exercise performance. Methods In this double-blind, randomized, parallel placebo-controlled trial, 60 recreationally active males (age, 27 ± 6 yr; body mass index, 23.8 ± 2.6 kg·m−2; V˙O2max, 47 ± 6 mL·min−1·kg−1) were subjected to 12 wk of triweekly endurance exercise training. After each session and each ni...
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

The Longitudinal Associations of Fitness and Motor Skills with Academic Achievement
Conclusion The changes in both aerobic and muscular fitness were positively associated with the changes in academic achievement during adolescence, whereas the changes in motor skills had only borderline significant association. However, better motor skills, although not systematically, independently predicted better academic achievement 1 yr later, whereas aerobic or muscular fitness did not. Better academic achievement predicted better motor skills, aerobic fitness, and muscular fitness. Developmental changes in adolescence may induce parallel and simultaneous changes in academic achievement and PF.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Examining Arm Vascular Function and Blood Flow Regulation in Row-trained Males
Conclusion This study revealed that vascular function and blood flow regulation were significantly different in row-trained males when compared with untrained controls evidenced by greater shear-induced BA dilation and lower arm blood flow during progressive handgrip exercise.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Foot Angle and Loading Rate during Running Demonstrate a Nonlinear Relationship
Vertical loading rates are typically found to be lower in forefoot compared to rearfoot strikers, promoting the idea that forefoot striking is desirable and may reduce running injury risk. However, prior work using linear models has shown that foot inclination angle (FIA) at initial contact is a poor predictor of vertical loading rate, suggesting a more complex association exists. Purpose To determine if a nonlinear model superiorly describes the relationship between FIA and average vertical loading rate (AVLR). Secondary analyses assessed the influence of sex and sport on the association between FIA and AVLR. Methods ...
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Relationship of Foot Strike Pattern and Landing Impacts during a Marathon
Purpose Foot strike patterns (FSP) influence landing mechanics, with rearfoot strike (RFS) runners exhibiting higher impact loading than forefoot strike (FFS) runners. The few studies that included midfoot strike (MFS) runners have typically grouped them together with FFS. In addition, most running studies have been conducted in laboratories. Advances in wearable technology now allow the measurement of runners’ mechanics in their natural environment. The purpose of this study was to examine the relationship between FSP and impacts across a marathon race. Methods A total of 222 healthy runners (119 males, 103 females...
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Interactive Virtual Reality Reduces Quadriceps Pain during High-Intensity Cycling
Conclusion Compared with a static VR/motor imagery control condition, I-VR during brief, high-intensity, fatigue-inducing leg cycling attenuates quadriceps pain intensity without reducing performance.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise
Conclusions This indicates that dermal Ca loss was not the primary trigger for the increases in PTH and CTX during exercise. Further research is necessary to understand the causes and consequences of the disruption in Ca homeostasis during exercise and specifically the extravascular shift in iCa.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Effect of a Ketogenic Diet on Submaximal Exercise Capacity and Efficiency in Runners
Purpose We investigated the effect of a 31-d ketogenic diet (KD) on submaximal exercise capacity and efficiency. Methods A randomized, repeated-measures, crossover study was conducted in eight trained male endurance athletes (V˙O2max, 59.4 ± 5.2 mL⋅kg−1⋅min−1). Participants ingested their habitual diet (HD) (13.1 MJ, 43% [4.6 g⋅kg−1⋅d−1] carbohydrate and 38% [1.8 g⋅kg−1⋅d−1] fat) or an isoenergetic KD (13.7 MJ, 4% [0.5 g·kg−1⋅d−1] carbohydrate and 78% [4 g⋅kg−1⋅d−1] fat) from days 0 to 31 (P 70% V˙O2max, as evidenced by increased energy expenditure and oxygen uptake that could...
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

One-Year Lifestyle Intervention, Muscle Lipids, and Cardiometabolic Risk
Purpose Low-attenuation muscle (LAM) area at mid-thigh, a computed tomography (CT)–derived index of intramuscular lipids, is associated with insulin resistance, obesity, and type 2 diabetes. The present study aimed at testing the hypothesis that changes in LAM area in trunk muscles from a single abdominal scan could provide relevant information to evaluate the effects of a lifestyle intervention without the use of a mid-thigh CT scan. Methods Cardiometabolic risk variables, including waist circumference, lipoprotein–lipid profile, glucose tolerance, and cardiorespiratory fitness, were assessed in a sample of 102 d...
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Effects of Instrument-assisted Soft Tissue Mobilization on Musculoskeletal Properties
Conclusion IASTM can improve joint range of motion, without affecting the mechanical and neural properties of the treated muscles.
Source: Medicine and Science in Sports and Exercise - September 17, 2019 Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

Work and Activities job description
So I have a quick question regarding one of my activity description. I worked as an EMT for a particular company, however, I had many different roles. The two main roles I listed were: 1) Patient care - I worked XX hours. 2) XXXXXXXX (not related to my job as an EMT with the company; instead, it is a different job within the same company) - I worked YY hours. However, I also had many other roles besides patient care with my job as an EMT, such as community outreach, meetings, and cleaning... Work and Activities job description
Source: Student Doctor Network - September 17, 2019 Category: Universities & Medical Training Authors: premedlross23 Tags: Pre-Medical - MD Source Type: forums

Non-trad lurker/career change - advice/WAMC?
Hi guys, long-time lurker, I made the decision (with my wife) to quit my job and go back to school a couple years ago while teaching abroad. Finally made the move and started a DIY post-bacc 2018 summer. Short background story: Premed through high school - went to college, fell in love with social science. (One D in calculus freshman year, only blemish for sGPA). Graduated with 3.0 cGPA w/ degree in International Relations w/ Communications minor in 2008. Worked in business/accounting 1... Non-trad lurker/career change - advice/WAMC?
Source: Student Doctor Network - September 17, 2019 Category: Universities & Medical Training Authors: taylorthegr8 Tags: Nontraditional Students Source Type: forums

Intrauterine Device Insertion during Cesarean Section in Women without Prenatal Contraception Counseling: Lessons from a Country with High Cesarean Rates
Conclusion Two thirds of the women who continued with IUD at 6 months had undergone 2 ormore cesarean sections. Since offering trial of labor is unusual after 2 or more previous cesareans, we believe that offering IUD after admission for delivery may reduce the risk of repeated cesarean sections and its inherent risks.Resumo Objetivo O momento da admiss ão para o parto pode ser considerado inapropriado para oferecer o dispositivo intrauterino (DIU) para mulheres sem aconselhamento contraceptivo pré-natal. Entretanto, em países com elevadas taxas de cesáreas e aconselhamento contraceptivo deficiente, essa estratégia po...
Source: Revista Brasileira de Ginecologia e Obstetricia - September 17, 2019 Category: OBGYN Source Type: research

Can't get a Committee Letter. Will Letter Packets be enough or will I get rejected for not having a Committee Letter ?
Long story short, my school requires a 3.3 sgpa for 2 years in order to get a committe letter, however my sgpa was in the 2.8 range for a while until I got my act together and got an upward trend in the last 1.5 years and got my sgpa up to a 3.35 (overall to a 3.53). My MCAT is decent enough for me to apply (514) and my ECs are pretty good (as well as my letter of recs) but I'm kind of scared that my low sgpa along with the lack of committee letter will get me rejected from most MD/DO... Can't get a Committee Letter. Will Letter Packets be enough or will I get rejected for not having a Committee Letter ?
Source: Student Doctor Network - September 17, 2019 Category: Universities & Medical Training Authors: smhmd Tags: Pre-Medical - MD Source Type: forums

Occlusal Splints and Periodontal/Implant Therapy.
CONCLUSIONS: Therefore, as it is a non-invasive and reversible therapy, occlusal splint use in patients with bruxism is proposed. PMID: 31522162 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Salivary Levels of Antimicrobial Peptides in Chronic Periodontitis Patients with Type 2 Diabetes.
CONCLUSIONS: LL-37 concentrations were highest in patients with T2DM+CP when compared with controls. LL-37 was positively correlated with age. HNP 1-3 levels were increased in groups with DM when compared to the groups without periodontitis. The role of AMPs is vital in the immunoinflammatory response in the pathogenesis of periodontitis and DM. PMID: 31522161 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Periapical Lesion on an Implant after Socket Shield Technique: A Case Report.
Authors: Stuani VT, Manfredi GGDP, Sant'Ana ACP, de Rezende MLR Abstract A 47-year-old Caucasian male presented with a radiolucent area around the apical region of an implant placed using the socket shield technique. A second surgical procedure was performed to curette the lesion and fill the defect with a xenogeneic bone graft. Twenty months after implant placement and 10 months after the second surgery, there was no sign of recurrence of the lesion and radiographic evaluation was consistent with new bone formation in the region. Thus, although numerous studies have demonstrated the effectiveness of the socket shi...
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Clinical and Radiographic Assessment of Single or Combined Treatment with Lepidium sativum and Alendronate of Non-Surgically Treated Chronic Periodontitis in Postmenopausal Osteoporotic Women.
CONCLUSIONS: Within the limits of the study, it is concluded that Lepidium sativum can be used in the treatment of osteoporotic postmenopausal women with chronic periodontitis who refuse treatment with ALN. The combined use of LS and ALN may have a synergistic effect resulting in a more favorable clinical response, increased bone mass than using ALN alone when combined with conventional therapy in treatment of chronic periodontitis in postmenopausal osteoporotic women. PMID: 31522159 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Estimation and Correlation of MMP-8 Levels in GCF and Serum with Wound Healing and Clinical Outcomes of Coronally Advanced Flap and Sub-Epithelial Connective Tissue Graft for Root Coverage - A Controlled Clinical Trial.
CONCLUSION: The present prospective study showed satisfactory post-surgical healing and root coverage outcome. MMP-8 levels and its increase/decrease during the early wound healing follows the expected temporal pattern. No significant correlation was noted between MMP-8 levels during early wound healing and root coverage outcomes. PMID: 31522158 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Using a Composite Graft of Natural 15% Chitosan Gel in the Management of Intrabony Defects: A Case Series.
CONCLUSION: Within the limits of this study, this case series study suggests that chitosan gel, along with bovine porous bone mineral, has a promising role to play in periodontal regeneration. PMID: 31522157 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

Meeting Report 1st International Academy of Periodontology Research Conference (IAPRC).
The objectives of the IAPRC were: to examine the state of the art in periodontal research, to encourage new scientific collaborations and to develop new directions for research. PMID: 31522156 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - September 17, 2019 Category: Dentistry Tags: J Int Acad Periodontol Source Type: research

The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial
ConclusionsOral administration of vitamin K2 in patients on haemodialysis reduced serum uc-MGP levels but did not have an effect in the progression of aortic calcification.
Source: International Urology and Nephrology - September 17, 2019 Category: Urology & Nephrology Source Type: research

1 in 16 US women forced or coerced into first-time sex
Many American women are physically forced or coerced into having sex for the first time, and a new study suggests these women have a higher risk for developing sexual and general health problems.
Source: Reuters: Health - September 16, 2019 Category: Consumer Health News Tags: healthNews Source Type: news