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Georgia Gov. Kemp signs medical marijuana bill
Georgia Republican Gov. Brian Kemp has signed into law a bill that would allow certain patients to access a low-potency cannabis oil they can already legally use
Source: ABC News: Health - April 18, 2019 Category: Consumer Health News Tags: Health Source Type: news

"Medicare for All" giving health-care stocks the chills
All the talk about Sen. Bernie Sanders' signature health plan seems to be taking a toll on insurance and medical stocks
Source: Health News: CBSNews.com - April 18, 2019 Category: Consumer Health News Source Type: news

CDC warns of salmonella outbreak linked to raw tuna
"Consumers who order sushi made with raw tuna, including 'spicy tuna,' from a restaurant or grocery store should ask if the tuna is supplied by Jensen Tuna," the CDC says
Source: Health News: CBSNews.com - April 18, 2019 Category: Consumer Health News Source Type: news

Proinflammatory effects of dust storm and thermal inversion particulate matter (PM 10 ) on human peripheral blood mononuclear cells (PBMCs) in vitro: a comparative approach and analysis
This study compared the proinflammatory cytokines tumor necrosis factor alpha (TNF- α), interleukin 6 (IL-6), and interleukin 1-beta (IL1-β) secretions of PBMCs exposed to PM10 of dust storm and inversion. We collected PM10 samples during the spring and autumn seasons in two locations. Isolated PBMCs were exposed separately to 50, 150, and 300  μg/ml of different type of PM10 for 4 and 24  h. The mean concentrations of TNF-α for the PM of dust storm and inversion were 6305.61 ± 2421 and 6651.74 ± 2820, respectively. Also the mean concentrations of IL1-β for the PM of dust storm and inversion were 556.86 ...
Source: Journal of Environmental Health Science and Engineering - April 18, 2019 Category: Environmental Health Source Type: research

Molecules, Vol. 24, Pages 1531: Determination of the 15N-Nitrate/14N-Nitrate Ratio in Plant Feeding Studies by GC –MS
Molecules, Vol. 24, Pages 1531: Determination of the [15N]-Nitrate/[14N]-Nitrate Ratio in Plant Feeding Studies by GC–MS Molecules doi: 10.3390/molecules24081531 Authors: Sebastian Schramm Maria Fe Angela Comia Boco Sarah Manzer Oliver König Tong Zhang Fatima Tuz Zohora Mony Adebimpe Nafisat Adedeji-Badmus Brigitte Poppenberger Wilfried Rozhon Feeding experiments with stable isotopes are helpful tools for investigation of metabolic fluxes and biochemical pathways. For assessing nitrogen metabolism, the heavier nitrogen isotope, [15N], has been frequently used. In plants, it is usually applied in ...
Source: Molecules - April 18, 2019 Category: Chemistry Authors: Sebastian Schramm Maria Fe Angela Comia Boco Sarah Manzer Oliver K önig Tong Zhang Fatima Tuz Zohora Mony Adebimpe Nafisat Adedeji-Badmus Brigitte Poppenberger Wilfried Rozhon Tags: Article Source Type: research

Imperfect Bayesian inference in visual perception
by Elina Steng ård, Ronald van den Berg Optimal Bayesian models have been highly successful in describing human performance on perceptual decision-making tasks, such as cue combination and visual search. However, recent studies have argued that these models are often overly flexible and therefore lack explanatory power. Moreover, there are indications that neural computation is inherently imprecise, which makes it implausible that humans would perform optimally on any non-trivial task. Here, we reconsider human performance on a visual-search task by using an approach that constrains model flexibility and tests for comput...
Source: PLoS Computational Biology - April 18, 2019 Category: Biology Authors: Elina Steng ård Source Type: research

News at a glance
Source: ScienceNOW - April 18, 2019 Category: Science Tags: Scientific Community In Brief Source Type: news

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T > C Mutation in the Mitochondrial MTND3 Gene
Conclusion The m.10191T>C mutation in the mtDNA of the complex I (CI) subunit of MTND3 results in the substitution of a highly conserved amino acid (p.Ser45Pro) within the ND3 protein, leading to CI dysfunction through impaired enzyme catalysis rather than impaired stability or assembly, causing a broad clinical spectrum of disorders (26). Patients with the m.10191T>C mutation are rare. In the present study, we report on a family of patients with the extremely rare adult-onset Leigh-like syndrome with the m.10191T>C mutation. Including the two patients from our reported family, the m.10191T...
Source: Frontiers in Neurology - April 18, 2019 Category: Neurology Source Type: research

Viruses, Vol. 11, Pages 358: Distribution and Phylogeny of Erythrocytic Necrosis Virus (ENV) in Salmon Suggests Marine Origin
Curtis A. Suttle Viral erythrocytic necrosis (VEN) affects over 20 species of marine and anadromous fishes in the North Atlantic and North Pacific Oceans. However, the distribution and strain variation of its viral causative agent, erythrocytic necrosis virus (ENV), has not been well characterized within Pacific salmon. Here, metatranscriptomic sequencing of Chinook salmon revealed that ENV infecting salmon was closely related to ENV from Pacific herring, with inferred amino-acid sequences from Chinook salmon being 99% identical to those reported for herring. Sequence analysis also revealed 89 protein-encoding seque...
Source: Viruses - April 18, 2019 Category: Virology Authors: Veronica A. Pagowski Gideon J. Mordecai Kristina M. Miller Angela D. Schulze Karia H. Kaukinen Tobi J. Ming Shaorong Li Amy K. Teffer Amy Tabata Curtis A. Suttle Tags: Article Source Type: research

A Novel Citrullinated Modification of Histone 3 and Its Regulatory Mechanisms Related to IPO-38 Antibody-Labeled Protein
In this study we adopted an all-in-one method. Primers designed according to the two gRNA sequences and the tracRNA-U6 vector sequences were used to produce a gRNA1-tracRNA-U6-gRNA2 fragment. Then the proper fragment was ligated into the lentiCRISPRv2 vector and verified by sequencing. Lentiviral Packaging and Stable Cell Line Screening The constructed eukaryotic expression vector and gene knockdown vector were transfected into the 293T cells with the packaging plasmids psPAX2 and pMD2.G using Lipofectamine 2000 (Thermo Fisher, Massachusetts, USA). The lentivirus was harvested 48 h after transfection, and the lentivirus ...
Source: Frontiers in Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Impact of Hepatitis Virus on the Feasibility and Efficacy of Anticancer Agents in Patients With Hepatocellular Carcinoma in Phase I Clinical Trials
This study was approved by the NCCH institutional review board and performed in compliance with our institutional guidelines. Patients positive for anti-HCV antibody or HBV antigen (HBsAg) were considered to have HCC due to chronic viral hepatitis, whereas those without anti-HCV antibody nor HBsAg were considered to have HCC by another etiology (non-B/non-C). All medical records were reviewed to summarize the patients' clinical characteristics, treatments, and outcomes based on the status of chronic viral hepatitis. The baseline clinical characteristics included age, gender, ECOG-performance status (PS), treatmen...
Source: Frontiers in Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Environmental and Other Extrinsic Risk Factors Contributing to the Pathogenesis of Cutaneous T Cell Lymphoma (CTCL)
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Post-surgical Thyroid Bed Pyoderma Gangrenosum Mimicking Recurrent Papillary Thyroid Carcinoma
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good progn...
Source: Frontiers in Endocrinology - April 18, 2019 Category: Endocrinology Source Type: research

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity
In this study we show that different level of the neuronal activity can trigger Ca2+ dynamics in astrocyte with various spatio-temporal characteristics which can lead to different astrocytic-induced regulatory effects on synaptic transmission. The minimal synaptic activity causes the fast and local Ca2+ elevation in astrocytic process. This small Ca2+ signal triggers the gliotransmission in the active synapse induces localized regulatory astrocytic feedback of the synapse (Figure 6). Increasing frequency of synaptic activity can produce Ca2+ signal which can spread to another astrocytic process (Figure 7) a...
Source: Frontiers in Physiology - April 18, 2019 Category: Physiology Source Type: research

The Sensory Machinery of the Head Louse Pediculus humanus capitis: From the Antennae to the Brain
This study showed that although head lice are arrested around human scalp samples, they did not show differences between the human samples of different volunteers nor with the aging of the scalp sample (i.e., 60 h-old samples are as much attractive as 0 h-old samples) (Ortega Insaurralde et al., 2016). Thus, a piece of filter paper (1 cm × 1 cm) was rubbed during 30 s against the scalp of one 30-year-old female volunteer who had not bathed or used perfumed products in the 24 h previous to the extraction. Immediately after rubbing, the filter paper was located ...
Source: Frontiers in Physiology - April 18, 2019 Category: Physiology Source Type: research

The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves
Conclusion It was established that both the nerve excitation conduction and the transection of somatic nerves lead to profound changes in the lipid composition. Not only the number of phospholipids, but also the phospholipid fatty acid composition is changing. The key factors responsible for the detected changes are phospholipase A2 and phospholipase C activities. In the first place of the nerve fiber degenerative processes were both Ca 2+-dependent and Ca 2+-independent phospholipase A2 activation in the fiber’s distal part, which associated with of the axonal transport blocking. Another factor affecting the nerv...
Source: Frontiers in Physiology - April 18, 2019 Category: Physiology Source Type: research

Concurrent Statistical Learning of Ignored and Attended Sound Sequences: An MEG Study
This study was supported by the Kawai Foundation for Sound Technology and Music and The Kao Foundation for Arts and Sciences. The funders had no role in the study, and in this manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Abla, D., Katahira, K., and Okanoya, K. (2008). On-line assessment of statistical learning by event-related potentials. J. Cogn. Neurosci. 20, 952–964. doi: 10.1162/jocn.2008.20058 PubMed Abstract | CrossRef Full...
Source: Frontiers in Human Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

The Macro View – Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
April 18, 2019 Edition.-----The big news is that we are entering the 2nd week of the election campaign and this far – other than a load of nonsense on electric cars things are rolling on. Only 4 and a bit weeks to go. The battle-lines of Tax vs Health are now pretty clear!Brexit is on hold as the Parliament takes a short Easter break. The outcome is pretty unclear as seems to be the health of the world economy – with the IMF suggesting all is not well, Brexit aside.Trump seems to have had a quiet week and nothing really grabbed my attention. In late breaking news is seems the North Koreans have just launched a new tact...
Source: Australian Health Information Technology - April 18, 2019 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Wearable Sensors Reveal Menses-Driven Changes in Physiology and Enable Prediction of the Fertile Window: Observational Study
Conclusions: Our contributions highlight the impact of artificial intelligence and machine learning’s integration into health care. By monitoring numerous physiological parameters simultaneously, wearable technology uniquely improves upon retrospective methods for fertility awareness and enables the first real-time predictive model of ovulation.
Source: Journal of Medical Internet Research - April 18, 2019 Category: General Medicine Authors: Brianna Mae Goodale Mohaned Shilaih Lisa Falco Franziska Dammeier Gy örgyi Hamvas Brigitte Leeners Source Type: research

Bacterial Community Succession, Transmigration, and Differential Gene Transcription in a Controlled Vertebrate Decomposition Model
This study is one of the first to provide data of expressed bacterial community genes, alongside transmigration and structural changes of microbial species during laboratory controlled vertebrate decomposition. This is an important dataset for studying the effects of the environment on bacterial communities in an effort to determine which bacterial species and which bacterial functional pathways, such as amino acid metabolism, provide key changes during stages of decomposition that relate to the PMI. Finding unique PMI species or functions can be useful for determining time since death in forensic investigations. In...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Regulator directs drug manufacturers to incorporate new recorded adverse effects in leaflets
​The aim is to make the patients and doctors aware of the new adverse reactions of certain drugs which are prescribed frequently for certain conditions
Source: The Economic Times - April 18, 2019 Category: Consumer Health News Source Type: news

The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype
In this study, we aimed to identify gene expression patterns associated with the survival and re-growth of B. burgdorferi in the antibiotic environment. While a similar study in which RNASeq was applied to antibiotic treatment of B. burgdorferi was conducted (Feng et al., 2015), several important distinctions between that study and ours should be made. In that report by Feng et al, in vitro-cultured Bb were treated with either doxycycline or amoxicillin (50 μg/mL) for 6 days and then subjected to RNASeq, with comparison to the untreated control. Genes that were up-regulated by 2-fold or more were ascribed significan...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Screening of Polyvalent Phage-Resistant Escherichia coli Strains Based on Phage Receptor Analysis
In this study, eight phages were sequentially separated from sewage (Table 2). Phages vB_EcoS_IME18 (IME18), vB_EcoS_IME253 (IME253), vB_EcoM_IME281 (IME281), vB_EcoM_IME338 (IME338), vB_EcoM_IME339 (IME339), vB_EcoM_IME340 (IME340), vB_EcoM_IME341 (IME341), and vB_EcoS_IME347 (IME347) formed clear, bright plaques on soft agar plates (Supplementary Figure S2). TEM imaging showed that phages IME281 (Figure 1), IME339 (Figure 2), IME340 (Figure 3), and IME341 (Figure 4) had a prolate head and a tail with a contractile sheath. The elongated icosahedral head was ∼100 nm long and 80 nm wide, while the tail tube was "...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Source Community and Assembly Processes Affect the Efficiency of Microbial Microcystin Degradation on Drinking Water Filtration Membranes
Discussion Physical Properties of Lake and Stream Water Fed GDM Biofilms As observed previously, permeate flux in GDM systems stabilized after approximately 1 week of operation (Peter-Varbanets et al., 2010). Biomass addition led to twice as much hydraulic resistance and>3 times thicker biofilms (Figure 2A and Supplementary Figure S1), resulting in lower flux (McCarthy et al., 2002; Kohler et al., 2014; Silva et al., 2018). Permeate flux and biofilm thickness of the biomass-amended biofilms in ExpL and ExpS were similar, suggesting that their hydraulic properties were neither affected by the respective characteristics of...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Salmonella enterica Growth Conditions Influence Lettuce Leaf Internalization
Conclusion Internalization of STm in lettuce leaf was affected by bacterial growth conditions. Exposure of the pathogen to mild stresses enhanced leaf internalization, possibly due to bacterial preadaptation, which also contributes to lettuce leaf internalization. The universal stress genes uspAB, ydaA, yecG, and ybdQ, but not ynaF gene, are required for lettuce leaf internalization. Further characterization of their role in STm internalization is needed in order to better understand how Salmonella and possibly other HPOP adapt to the hostile plant environment. Author Contributions SS and YK designed the study and analy...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure –Activity Relationship) Models
Conclusion Polyphenols exhibited very different antibacterial activity against the six microbial strains studied that are representative of the foodborne pathogenic and food spoilage bacteria. The same polyphenol may be effective on one type of Gram-positive (or Gram-negative) strain and ineffective on the other ones indicating strain-dependent effect. This is the case for example of 5,7-dihydroxy-4-phenylcoumarin (HUQ) which exhibited 93.5% BLD against L. monocytogenes, 89.9% BLD against S. aureus and a slight bacterial growth-promoting effect (BLD of about −26.1%) for E. coli. Moreover, the antibacterial effect ...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae
Conclusion: Some Lactobacillus strains exhibit anti-CRE activity, which suggests potential applications for controlling or preventing CRE colonization or infection. Introduction Although Enterobacteriaceae are normal flora of the human intestinal system, they are also common pathogens causing human infections in the setting of both community-acquired and healthcare-associated infections (Hsueh et al., 2010; Toh et al., 2012; Lai et al., 2014; Jean et al., 2016). In this era of widespread antibiotic resistance, Enterobacteriaceae are no exception. Recently, the emergence of carbapenem-resistant Enterobacteriaceae (C...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells
This study was carried out in accordance with the German Law on Care and Use of Laboratory Animals. Euthanasia and organ preparation were approved by the local authorities (Landratsamt Erlangen-Hoechstadt, Erlangen, Germany). Author Contributions LC designed the study, planned, and performed experiments, analyzed and interpreted data and wrote the manuscript. SP designed the study, interpreted data, and edited the manuscript. JT initiated the study and supported the work. H-MJ made key suggestions, assisted in the design of experiments, interpreted data and critically reviewed the manuscript. WS designed the study, plann...
Source: Frontiers in Immunology - April 18, 2019 Category: Allergy & Immunology Source Type: research

Identification of a New HCV Subtype 6xg Among Injection Drug Users in Kachin, Myanmar
This study has several limitations. Frist, HCV exists in a quasispecies form in human body (Martell et al., 1992). It will be better to obtain a single full-length genome sequence from a single virus. However, because of failure in amplification of near full-length HCV genome (>5000 bps), we amplified and sequenced 10 overlapping HCV genomic segments to obtain the whole genome sequence. Therefore, the genomic sequences obtained in this study contain some ambiguous (or degenerate) nucleotides (quasispecies population). Second, previous studies showed that vast majority of IDUs in Yunnan, especially in the China-Myanmar bord...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression
In conclusion, severe lethal ileitis induced by oral T. gondii infection is attenuated by blockade of ST2 signaling and may be mediated in part by endogenous IL-22. Introduction Toxoplasma gondii is an opportunistic parasite with a worldwide distribution triggering an innate immune response. This response characterized by a rapid recruitment of neutrophils following the entry of infectious tachyzoites from the lumen into the intestinal mucosa eliciting a strong inflammatory Th1 response associated with the production of IFNγ, IL-12 and TNF-α. The parasite activates dendritic cells and macrophages to...
Source: Frontiers in Immunology - April 18, 2019 Category: Allergy & Immunology Source Type: research

Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species From Ready-to-Eat Seafood
Conclusion This study revealed that Enterococcus species with biofilm potentials and extracellular virulence properties extensively occur in retail RTE shrimps. A significant number of isolated strains are resistant to antibiotics and harbor resistant and virulent genes, denoting a significant route of resistance and virulence dissemination to bacteria in humans. There is an inadequate understanding of the intricacies of antibiotic-resistant enterococci of food origin that belong to enterococci aside from E. faecium and E. faecalis. Findings from this study reveal detailed antibiotic resistance of E. durans, E. casselifla...
Source: Frontiers in Microbiology - April 18, 2019 Category: Microbiology Source Type: research

Editorial: The Pathogenic Yersiniae –Advances in the Understanding of Physiology and Virulence, Second Edition
Editorial: The Pathogenic Yersiniae–Advances in the Understanding of Physiology and Virulence, Second Edition Matthew S. Francis1* and Victoria Auerbuch2* 1Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden2Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, United States Editorial on the Research Topic The Pathogenic Yersiniae–Advances in the Understanding of Physiology and Virulence, Second Edition Of the 18 known Yersinia species, Y. pestis, Y. pseudotub...
Source: Frontiers in cellular and infection microbiology - April 18, 2019 Category: Microbiology Source Type: research

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathw...
Source: Frontiers in cellular and infection microbiology - April 18, 2019 Category: Microbiology Source Type: research

Molecules, Vol. 24, Pages 1539: Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum
mar Kamel New reliable and robust potentiometric ion-selective electrodes were fabricated using poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) as the solid contact between the sensing membrane and electrical substrate for an acetylcholine (ACh) bioassay. A film of PEDOT/PSS was deposited on a solid carbon screen-printed platform made from ceramic substrate. The selective materials used in the ion-selective electrode (ISE) sensor membrane were acetylcholinium tetraphenylborate (ACh/TPB/PEDOT/PSS-ISE) (sensor I) and triacetyl-β-cyclodextrin (β-CD/PEDOT/PSS-ISE) (sensor II...
Source: Molecules - April 18, 2019 Category: Chemistry Authors: Ashmawy Almehizia Youssef El-Galil E. Amr Al-Omar Kamel Tags: Article Source Type: research

Sultan of Brunei stripped of RCGP honours
The College meets next week to discuss its future professional relations with 'repressive regimes' Related items fromOnMedica RCGP 'reviewing' links with Brunei amid anger over LGBT laws Doctors slam Brunei for ‘abhorrent’ laws Tobacco production 'breaches human rights laws ’ Women second-class citizens when it comes to healthcare Genetic risk model could guide prostate cancer screening
Source: OnMedica Latest News - April 18, 2019 Category: UK Health Source Type: news

Priory group fined £300,000 over 14-year-old's death
Her mother is calling for the company's NHS contract to be ended Related items fromOnMedica Child mental health services at breaking point Child to adult mental health transfer is inadequate Experts urge radical action on mental health crises Mentally-ill children locked in police cells NHS is failing patients with mental health problems
Source: OnMedica Latest News - April 18, 2019 Category: UK Health Source Type: news

'Bubble Boy' disease reversed with HIV
Children born with severe combined immunodeficiency treated with genetically altered HIV Related items fromOnMedica Drugmakers 'on track' to produce swine flu vaccine 'MMR should be compulsory', says public health expert A stab in the dark Rapid rise in flu consultations putting strain on GPs BMJ report questions swine flu jab transparency
Source: OnMedica Latest News - April 18, 2019 Category: UK Health Source Type: news

'Revived' dead pig brains offer new research hopes
Ethicists fear research animals could end up in a 'grey-area - not alive, but not completely dead' Related items fromOnMedica Report helps explain Gulf War illness One in two women and one in three men will develop neurological disease NICE sets care standards for spasticity ‘Suicide tourism’ to Switzerland doubles in four years Head injuries linked to Alzheimer ’s and other disorders
Source: OnMedica Latest News - April 18, 2019 Category: UK Health Source Type: news

Experiences and Perceptions of Police Officers Concerning Their Interactions With People With Serious Mental Disorders for Compulsory Treatment
Conclusions: This study highlights the perceptions and experiences of police officers about the process of compulsory admission, and identifies areas of unmet needs. These findings help to raise awareness of their needs, improving this process, and ensuring a more humane and effective approach. Introduction Compulsory admission and treatment is a topic of intense debate in psychiatry. This is due to the effects such policies have on people's lives, given that it involves detaining them against their wishes and restricting their individual liberty (1). Compulsory treatment is ethically challenging, often assoc...
Source: Frontiers in Psychiatry - April 18, 2019 Category: Psychiatry Source Type: research

Increased Neural Activity in Hazardous Drinkers During High Workload in a Visual Working Memory Task: A Preliminary Assessment Through Event-Related Potentials
DiscussionAlthough many n-back studies have not reported any significant difference between healthy participants and excessive alcohol drinkers, significant neural differences have been found indexing compensatory neural processing during variation in the cognitive load (40–44, 46). Moreover, these neural differences appear to be observable throughout the information processing stream when electrophysiological measures (characterized by a better temporal resolution) are used (52–56). In the present ERP study, and for the first time to our knowledge, increasing memory load (N2 and N3-back tasks) has been place...
Source: Frontiers in Psychiatry - April 18, 2019 Category: Psychiatry Source Type: research

The effect of geodemographic factors on the attendance rates at a regional diabetic retinopathy treatment centre
ConclusionThis study suggests a correlation between geodemographic factors (age, gender and commuting distance) and attendance at a DRT Centre. The longer commuting distance for Kerry patients contributes to their higher non-attendance rates indicating a need to provide a Kerry-based satellite treatment centre to improve accessibility.
Source: Irish Journal of Medical Science - April 18, 2019 Category: General Medicine Source Type: research

Sensors, Vol. 19, Pages 1851: The Strain Transfer Mechanism of Fiber Bragg Grating Sensor for Extra Large Strain Monitoring
ihao Zhao This research focuses on a desensitization method to develop a wide-range FBG sensor for extra-large strain monitoring, which is an essential requirement in large scale infrastructures or for some special occasions. Under appropriate hypotheses, the strain transfer distribution of wide-range FBG sensor based on the shear-lag theory is conducted to improve the accuracy of extra-large strain measurements. It is also discussed how the elastic modulus of adhesive layer affects the strain transfer rate. Two prototypes in different monitoring ranges are designed and fabricated by two layers of steel pipe encapsulat...
Source: Sensors - April 18, 2019 Category: Biotechnology Authors: Li Sun Chuang Li Chunwei Zhang Tianqi Liang Zihao Zhao Tags: Article Source Type: research

IgG Anti-ghrelin Immune Complexes Are Increased in Rheumatoid Arthritis Patients Under Biologic Therapy and Are Related to Clinical and Metabolic Markers
This study was supported by Instituto de Nutrición y Salud Kellogg's (INSK) by the funding program Apoyo a Proyectos de Investigación en Nutrición (APIN-2016) granted to ZR-C. The funding source had no involvement on the design nor any steps of the study. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments The authors would like to thank Instituto de Investigación en Ciencias Biomédicas and Centro de Invest...
Source: Frontiers in Endocrinology - April 18, 2019 Category: Endocrinology Source Type: research

Sensing Glucose in the Central Melanocortin Circuits of Rainbow Trout: A Morphological Study
This study was supported by research grants from Spanish Agencia Estatal de Investigación (AEI) and European Fund of Regional Development (FEDER) to JC-R (AGL2016-74857-C3-3-R) and JS (AGL2016-74857-C3-1-R). CO-R has a predoctoral fellowship from AEI (BES-2014-068040). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Blouet C, Schwartz GJ. Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res. (2010) 209:1ȁ...
Source: Frontiers in Endocrinology - April 18, 2019 Category: Endocrinology Source Type: research

A Case of Congenital Isolated Adrenocorticotropic Hormone Deficiency Caused by Two Novel Mutations in the TBX19 Gene
In conclusion, we reported a CIAD case with two novel mutations that presented with recurrent seizures and hypoglycemia. When an infant shows recurrent hypoglycemia, with seizures and low plasma levels of ACTH and cortisol, CIAD should be take into consideration, even if the patient has other hormonal abnormalities. Genetic analysis is a powerful tool to confirm the diagnosis, which helped us to identify two novel mutations in our patient. In addition, the lack of an obvious circadian rhythm of ACTH and cortisol before treatment may be a specific characteristic of this disease. Ethics Statement This study was carried out...
Source: Frontiers in Endocrinology - April 18, 2019 Category: Endocrinology Source Type: research

Neurophysiological Analysis of Intermanual Transfer in Motor Learning
In this study, MEPs were induced during the subject’s imaged kinesthetic MI. This involves recalling muscle contraction based on a muscle sensory image and was reported to indicate the activity of brain regions similar to those involved in actual muscle contraction (Ruby and Decety, 2001). In the transfer training group, the muscle sensory image evaluation correlated to the actual task execution with the right hand. As a result, it was easy to recall the kinesthetic MI for the training task, thus affecting MI of the non-trained limbs so that MEP changes occurred in the left hand’s MI. In addition, brain exc...
Source: Frontiers in Human Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects
Conclusion The aim of this paper was to examine whether military tDCS use can be efficacious and ethical in military settings. Our assessment is that tDCS offers a number of cognitive, motor, and perceptual enhancement opportunities which could provide value in military situations like training and operations. There is potential scope for use in a number of key areas that directly affect practical battlefield advantage and survivability, such as deceptive capabilities, risk-taking, threat detection, perception, and physiological improvement. Additionally, tDCS has the potential to improve command and control decision maki...
Source: Frontiers in Human Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 18, 2019 Category: Drugs & Pharmacology Source Type: research

Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors
Conclusion In conclusion, we demonstrated that the combination of FUS and microbubbles could increase the NK-92MI cells’ infiltration into tumors in this study. The combination of FUS and NK-92MI had a much better therapeutic effect when compared with the PBS group, but no superior therapeutic effect when compared with the NK-92MI group. In total, FUS and microbubbles can improve NK cells’ infiltration into tumors, but future work is still needed to improve NK-92MI cells’ delivery efficiency for solid tumor treatment. Ethics Statement This study was carried out in accordance with the recommendations...
Source: Frontiers in Pharmacology - April 18, 2019 Category: Drugs & Pharmacology Source Type: research

Reply to: NEWS2 needs to be tested in prospective trials involving patients with confirmed hypercapnia
O ’Driscoll et al. raise interesting points about our comparison of the National Early Warning Score (NEWS) and its modification, NEWS2.1
Source: Resuscitation - April 18, 2019 Category: Emergency Medicine Authors: Marco A.F. Pimentel, Gary B. Smith, Oliver C. Redfern, Stephen Gerry, Gary S. Collins, James Malycha, David Prytherch, Paul E. Schmidt, Peter J. Watkinson Tags: Letter to the Editor Source Type: research