Regular Exercise Linked to Slower Deterioration in Parkinson Disease

FRIDAY, Jan. 14, 2022 -- For patients with early Parkinson disease (PD), average regular overall physical activity levels over time are associated with slower deterioration of postural and gait stability, activities of daily living, and processing...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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Future studies are needed to develop specific motor imagery protocols.First Look
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Conditions:   Dexmedetomidine;   Postoperative Delirium;   Deep Brain Stimulation Interventions:   Drug: Dexmedetomidine;   Drug: 0.9% saline Sponsor:   Beijing Tiantan Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Curr Top Med Chem. 2022 Jan 19. doi: 10.2174/1568026622666220119111538. Online ahead of print.ABSTRACTBacopa monnieri (BM) is of immense therapeutic potential in today's world. This review is aimed to project the beneficial role of BM in disorders affecting the brain, including Alzheimer's disease, Parkinson's disease, stroke, epilepsy and depression. The active constituents and metabolites responsible for the effects of BM could be bacoside A and B, bacopaside I and II, bacopasaponin C, betulinic acid, asiatic acid, loliolide, ebelin lactone and quercetin. The mechanistic role of BM in brain disorders might be related to ...
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research
Ideal three-dimensional imaging of complex samples made up of micron-scale structures extending over mm to cm, such as biological tissues, requires both wide field of view and high resolution. For existing optics and detectors used for micro-CT (computed tomography) imaging, sub-micron pixel resolution can only be achieved for fields of view of
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: synchrotron micro-CT high resolution large field of view X-ray optics histotomography research papers Source Type: research
ConclusionNeuropsychiatric fluctuations temporarily matched the OFF MFs only in the OFF condition. These findings are useful to better manage OFF NMSs and support the need to further investigate associations between non-motor and motor symptoms in PD patients.
Source: Neurological Sciences - Category: Neurology Source Type: research
In this study, hVM1 clone 32 cells, a line of human neural stem cells, were characterized and subsequently transplanted in middle-aged Parkinsonian mice in order to examine cell replacement therapy as a treatment for PD. In vitro analyses revealed that these cells express standard dopamine-centered markers as well as others associated with mitochondrial and peroxisome function, as well as glucose and lipid metabolism. Four months after the transplantation of the hVM1 clone 32 cells, striatal expression of tyrosine hydroxylase was minimally reduced in all Parkinsonian mice but that of dopamine transporter was decreased to a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In right-handed patients with idiopathic rapid eye movement sleep behavior disorder (IRBD) or Parkinson's disease (PD), dopamine transporter (DAT) single-photon emission computed tomography (SPECT) shows a predominant nigrostriatal deficit in the left striatum. To confirm this hypothesis, we longitudinally investigated whether the nigrostriatal function is asymmetric in Japanese patients with IRBD.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
AbstractPatients with Parkinson ’s disease (PD) present with an advanced form of age-related muscle loss or sarcopenia. However, the search for a biomarker to accurately predict muscle loss in PD remains elusive. We evaluated the biomarkers of neuromuscular junction (NMJ) stability, including c-terminal agrin fragment-22 (CAF22) , brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) as predictors of muscle wasting and physical capacity in PD. Male, 63—78 years patients of PD, were investigated for physical capacity, handgrip strength (HGS), and circulating biomar...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
In conclusion, our study demonstrated that EA inhibits neuroinflammation and exerts neuroprotective effects by activating PI3K/Akt and inhibiting NF-κB and MAPK signal pathways in vivo and in vitro.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CAMBRIDGE, Mass., Jan. 18, 2022. BlueRock Therapeutics, a clinical stage biopharmaceutical company and wholly-owned subsidiary of Bayer AG, announced today the dose administration for the first patient in Canada in partnership with the University...
Source: - Clinical Trials - Category: Pharmaceuticals Source Type: clinical trials
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