Study: Silica nanoparticles can help promote stem cell growth

(Natural News) The cells in your body all serve a very specific purpose, but stem cells are basic cells that have the power to become nearly any type of cell your body needs. Doctors and researchers alike have been studying them for years to help understand how the body functions and how things go wrong...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Authors: Grier WK, Sun Han Chang RA, Ramsey MD, Harley BAC Abstract BACKGROUND: Orthopedic injuries often occur at the interface between soft tissues and bone. The tendon-bone junction (TBJ) is a classic example of such an interface. Current clinical strategies for TBJ injuries prioritize mechanical reattachment over regeneration of the native interface, resulting in poor outcomes. The need to promote regenerative healing of spatially-graded tissues inspires our effort to develop new tissue engineering technologies that replicate features of the spatially-graded extracellular matrix and strain profiles across the n...
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research
Authors: Wu D, Yu X, Wang J, Hui X, Zhang Y, Cai Y, Ren M, Guo M, Zhao F, Dou J Abstract Tumor vaccines offer a number of advantages for cancer treatment. In the study, the vaccination with cancer stem cells (CSCs) with high expression of the type I receptor tyrosine kinase-like orphan receptor (ROR1) was evaluated in a murine model for the vaccine's immunogenicity and protective efficacy against epithelial ovarian carcinoma (EOC). CD117+CD44+ CSCs were isolated from human EOC HO8910 cell line using a magnetic-activated cell sorting system; murine ID8 EOC suspension sphere cells, which are collectively known as can...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Contributor : Bum-Ho BinSeries Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusIn order to identify the genes whose expression was perturbed by ZIP13, we performed a gene expression microarray analysis for the RNAs isolated from WT and ZIP13-depleted human mesenchymal stem cell.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Mus musculus Source Type: research
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): Hikaru Sakamoto, Hidehiro Itonaga, Jun Taguchi, Takeharu Kato, Yasushi Sawayama, Tomayoshi Hayashi, Shiro Baba, Masako Moriuchi, Koichi Ohshima, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi MiyazakiAbstractA 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein-Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the d...
Source: Leukemia Research Reports - Category: Hematology Source Type: research
A patient from London who was HIV positive and diagnosed with cancer, agreed to have a stem cell transplant in hopes of curing his cancer. After treatment, not only was the patient cancer-free, but he is now living his life HIV-free. DNA contains gene CCR5, which almost everyone carries. The CCR5 gene in the stem cells given to the London patient contained a specific mutation that prevents the gene from “expressing” itself. This type of mutation block allows CCR5 to become naturally resistant to HIV. Because HIV attacks the CCR5 part of a gene, when doctors treated the patient for his cancer, they literally fed...
Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: blood disorder Cord Blood medical research stem cells Source Type: blogs
Publication date: Available online 23 April 2019Source: Stem Cell ResearchAuthor(s): HaniHosseini Far, Yudha Nur Patria, Ali Motazedian, Andrew G. Elefanty, Edouard G. Stanley, Shireen R. Lamande, John F. BatemanAbstractTo develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we have used gene editing to produce a facsimile of the patient heterozygous COL1A1 mutation in an established control iPSC line. The gene-edited line had a normal karyotype, expressed pluripotency markers and differentiated into cells representative of the three embryonic germ layers. This iPSC line and th...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 22 April 2019Source: Stem Cell ResearchAuthor(s): Rosa Montes, Pilar Mollinedo, Sonia Perales, Domingo Gonzalez-Lamuño, Veronica Ramos-Mejía, Jose L. Fernandez-Luna, Pedro J. RealAbstractADNP syndrome is an intellectual disability associated with Autism spectrum disorder caused by mutations in ADNP. We generated an iPSC line from an ADNP syndrome pediatric patient harboring the mutation p.Trp719* (GENYOi004-A). Peripheral blood mononuclear cells were reprogrammed using a non-transmissible form of Sendai viruses expressing the four Yamanaka factors (Oct3/4, SOX2, KLF4 and c-M...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 22 April 2019Source: Stem Cell ResearchAuthor(s): Han-I Lin, Yu-Che Cheng, Hui-Wen Ko, Cheng-Hao Wen, Huai-En Lu, Ching-Ying Huang, Patrick C.H. Hsieh, Chin-Hsien LinAbstractLeucine rich repeat kinase 2 (LRRK2) is the causative gene for autosomal-dominant familial forms of Parkinson's disease (PD). Here, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female patient with LRRK2 c.4111A > G (p.I1371V) mutation by using the Sendai-virus delivery system. The resulting iPSCs had a normal karyotype. The iPSCs also showed pluripotency c...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Researchers here report on discovering that an existing farnesyltransferase inhibitor drug reverses the accumulation of altered tau protein aggregates in a mouse model. The death and dysfunction of nerve cells in the neurodegenerative conditions known as tauopathies is driven by the formation of neurofibrillary tangles, made of tau protein. That in turn has deeper causes, such as the chronic inflammation produced by senescent cells and disruption of immune cell activity in the central nervous system, one of which is no doubt being adjusted in some way by the action of the drug in this case. As in all such quite indirect me...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method, pioneered by Dr Adam Perriman and colleagues, involves re-engineering the membranes of stem cells to effectively “ weld ” the cells together.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, Research; Institutes, Bristol BioDesign Institute, Faculty of Life Sciences, Faculty of Life Sciences, School of Cellular and Molecular Medicine; Press Release Source Type: news
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