Researchers look at the potential of Rhazya stricta Decne in preventing neurodegenerative diseases

(Natural News) Research has shown that Rhazya stricta Decne, a medicinal plant native to the Arabian Peninsula, could potentially be used as a therapeutic agent in neurodegenerative diseases. The study, which was published in BMC Complementary and Alternative Medicine, evaluated whether plant extracts from R. stricta affects the spread and specialization of NTERA-2 (NT2) pluripotent embryonal carcinoma cells. Extracts were derived from...
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In this study, we focused on the epigenetic regulation and function of RAI2 in colorectal cancer (CRC).
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Journal of Tissue Engineering and Regenerative Medicine,Volume 0, Issue ja, -Not available-.
Source: Journal of Tissue Engineering and Regenerative Medicine - Category: Biotechnology Authors: Source Type: research
We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas. Graphical abstract Teaser Shen et al. identify molecular characteristics that classify testicular germ cell tumor types, including a separate subset of seminomas defined by KIT mutations. This provides a set of candidate biomarkers for risk stratification and potential therapeutic targeting.
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Wei ML, Fan JT, Yu PH, Zhang WJ, Xu H, Liu Y Abstract Abdominal wall mass is not uncommon in clinic, but it is very rare that germ cell tumors (GCTs) arise in the abdominal wall. The authors review the case of a 34-year-old female with abdominal wall mixed malignant GCT composed of embryonal carcinoma and teratoma and combine the relative literature to explain why GCTs originate from anterior abdominal wall. PMID: 29787026 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. Circadian rhythm is absent in undifferentiated embryonic stem cells; it begins only after differentiation. We used pluripotent P19 embryonal carcinoma stem cells to check the biological clock before and after differentiation into neurons using retinoic acid. We show that the central clock genesARNTL (Bmal),Per2 andPer3, and the peripheral clock genesRev-erb- α andROR- α, oscillate before and after differentiation, as does the expression of the neuronal differen...
Source: Journal of Circadian Rhythms - Category: Biology Source Type: research
Authors: Saltzman AF, Cost NG Abstract While testicular germ cell tumors (T-GCTs) make up only 0.5% of pediatric malignancies and less than 2% of adult malignancies, they comprise 14% of adolescent malignancies, making it the most common solid tumor in this age group. The transition in incidence at this age is also accompanied by a transition in tumor histology with adolescents having mostly pure embryonal carcinoma and mixed nonseminomatous germ cell tumors. Similar to T-GCTs of all ages, surgical excision with orchiectomy is the standard initial step in treatment. Chemotherapy, retroperitoneal lymph node dissecti...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
ConclusionsThe present report is the first large scale study of clinical stage I NSGCTs in Japan. Active surveillance appears to be an effective treatment option for patients with clinical stage I NSGCTs.
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study aimed to investigate the relationship between LRWD1 expression and reactive oxygen species (ROS) level in human embryonal carcinoma cell line, NT2/D1 cells, which will help in understanding the transcriptional regulatory role of ROS in cells. Results showed that the exposure of NT2/D1 cells to various concentrations of hydrogen peroxide (H2O2) and the nitric oxide (NO) donor sodium nitroprusside (SNP) caused a significant increase in the mRNA and protein expression of LRWD1. In addition, LRWD1 promoter luciferase reporter assay, and Chromatin Immunoprecipitation assay (CHIP assay) showed that nuclear factor eryt...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Conclusions: The findings obtained from this single case support the assumption that DICER1 syndrome-related WDTC NOS may develop on a background of MNG, via a stepwise process, involving DICER1 somatic mutations and additional molecular events, distinct from the classic pathways of papillary/follicular carcinoma. PMID: 29538609 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Conclusion.Treatment of relapsed or refractory germ cell tumors with brentuximab vedotin can induce durable responses with a manageable toxicity profile.Implications for Practice.This case series of seven patients with relapsed or refractory CD30‐expressing germ cell tumors (GCTs) or sex cord stromal tumors demonstrates that brentuximab vedotin has activity against GCTs and is well tolerated in heavily pretreated patients with these aggressive tumor types. One patient achieved a complete response that has been durable for almost 4 years since the discontinuation of treatment with brentuximab vedotin. Therefore, brentuxim...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Genitourinary Cancer Source Type: research
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