Researchers look at the potential of Rhazya stricta Decne in preventing neurodegenerative diseases

(Natural News) Research has shown that Rhazya stricta Decne, a medicinal plant native to the Arabian Peninsula, could potentially be used as a therapeutic agent in neurodegenerative diseases. The study, which was published in BMC Complementary and Alternative Medicine, evaluated whether plant extracts from R. stricta affects the spread and specialization of NTERA-2 (NT2) pluripotent embryonal carcinoma cells. Extracts were derived from...
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CONCLUSIONS: In carefully selected cases, TSS appears to be a safe, feasible procedure with adequate cancer control that could preserve sexual function. PMID: 30169152 [PubMed - as supplied by publisher]
Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
aja B Abstract A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, submicromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasivenes...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
Journal of Tissue Engineering and Regenerative Medicine, EarlyView.
Source: Journal of Tissue Engineering and Regenerative Medicine - Category: Biotechnology Authors: Source Type: research
In this study, we use ChIP-Seq to identify Dppa4 binding genome-wide in three distinct cell types: mouse embryonic stem cells (mESC), embryonal carcinoma cells, and 3T3 fibroblasts ectopically expressing Dppa4. We find a core set of Dppa4 binding sites shared across cell types, and also a substantial number of sites unique to each cell type. Across cell types Dppa4 shows a preference for binding to regions with active chromatin signatures, and can influence chromatin modifications at target genes. In 3T3 fibroblasts with enforced Dppa4 expression, Dppa4 represses the cell cycle inhibitor Cdkn2c and activates Ets family tra...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
In this study, we focused on the epigenetic regulation and function of RAI2 in colorectal cancer (CRC).
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Journal of Tissue Engineering and Regenerative Medicine,Volume 0, Issue ja, -Not available-.
Source: Journal of Tissue Engineering and Regenerative Medicine - Category: Biotechnology Authors: Source Type: research
We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas. Graphical abstract Teaser Shen et al. identify molecular characteristics that classify testicular germ cell tumor types, including a separate subset of seminomas defined by KIT mutations. This provides a set of candidate biomarkers for risk stratification and potential therapeutic targeting.
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Wei ML, Fan JT, Yu PH, Zhang WJ, Xu H, Liu Y Abstract Abdominal wall mass is not uncommon in clinic, but it is very rare that germ cell tumors (GCTs) arise in the abdominal wall. The authors review the case of a 34-year-old female with abdominal wall mixed malignant GCT composed of embryonal carcinoma and teratoma and combine the relative literature to explain why GCTs originate from anterior abdominal wall. PMID: 29787026 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. Circadian rhythm is absent in undifferentiated embryonic stem cells; it begins only after differentiation. We used pluripotent P19 embryonal carcinoma stem cells to check the biological clock before and after differentiation into neurons using retinoic acid. We show that the central clock genesARNTL (Bmal),Per2 andPer3, and the peripheral clock genesRev-erb- α andROR- α, oscillate before and after differentiation, as does the expression of the neuronal differen...
Source: Journal of Circadian Rhythms - Category: Biology Source Type: research
Authors: Saltzman AF, Cost NG Abstract While testicular germ cell tumors (T-GCTs) make up only 0.5% of pediatric malignancies and less than 2% of adult malignancies, they comprise 14% of adolescent malignancies, making it the most common solid tumor in this age group. The transition in incidence at this age is also accompanied by a transition in tumor histology with adolescents having mostly pure embryonal carcinoma and mixed nonseminomatous germ cell tumors. Similar to T-GCTs of all ages, surgical excision with orchiectomy is the standard initial step in treatment. Chemotherapy, retroperitoneal lymph node dissecti...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
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