Niacin (vitamin B3) can prevent melanoma, scientists confirm

(Natural News) Although research is still in progress, there is currently no single drug or combination of drugs that can effectively treat the deadliest form of skin cancer known as melanoma. Fortunately, a recent study has shown that vitamin B3, or niacin, may play an important role in the prevention and progression of the disease....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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This study demonstrated promising anticancer and antibacterial effects of Artemia salina egg extracts. Our results suggest that pure bioactive compounds obtained from Artemia salina eggs can provide new insights into the mechanisms of colon and skin cancer, as well as Pseudomonas aeruginosa inhibition. PMID: 31198432 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In this study we investigated anti-melanoma and hepatoprotective activities of frankincense essential oil (FEO) in both in vitro and in vivo models. Pretreatment with FEO induce a significant (p
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Ávila-Román J, Talero E, de Los Reyes C, Zubía E, Motilva V, García-Mauriño S Abstract Oxylipins are metabolites derived from lipid peroxidation. The plant oxylipin methyl jasmonate (MJ) shows cytotoxic activity against cancer cell lines of various origins, with ATP-depletion being one of the mechanisms responsible for this effect. The cytotoxic activity of oxylipins (OXLs) isolated from the microalgae Chlamydomonas debaryana (13-HOTE) and Nannochloropsis gaditana (15-HEPE) was higher against UACC-62 (melanoma) than towards HT-29 (colon adenocarcinoma) cells. OXLs lowered...
Source: Natural Product Communications - Category: Biochemistry Tags: Nat Prod Commun Source Type: research
In this study verteporfin (Ver), a second-generation photosensitizer, has been conjugated with mesoporous silica nanoparticles (MSNs): the resulting Ver-MSNs are an efficient nanoplatforms used to enhance cargo capacity and cellular uptake. Our in vitro and in vivo studies investigated whether Ver-MSNs were able to reduce or inhibit melanoma growth. In vitro experiments performed using B16F10 mouse melanoma cells showed that Ver-MSNs stimulated by red light (693 nm) significantly decreased in vitro cells proliferation in a range of concentration between 0.1 μg/ml to 10 μg/ml. When Ver-MSNs (5 μg/ml in glyc...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
AbstractCarriers of pathogenic variants inCDKN2A have a 70% life-time risk of developing melanoma and 15 –20% risk of developing pancreatic cancer (PC). In the Netherlands, a 19-bp deletion in exon 2 ofCDKN2A (p16-Leiden mutation) accounts for most hereditary melanoma cases. Clinical experience suggests variability in occurrence of melanoma and PC inp16-Leiden families. Thereby, the risk of developing cancer could be modified by both environmental and genetic contributors, suggesting that identification of genetic modifiers could improve patients ’ surveillance. In a recent genome-wide association study (GWAS),...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
Conditions:   Mucosal Melanoma;   Advanced Cancer;   Apatinib;   SHR-1210 Intervention:   Drug: apatinib plus SHR-1210 Sponsor:   Henan Cancer Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractFew studies have investigated pricing and promotional practices used by the indoor tanning industry, despite their potential to promote indoor UV tanning —a well-established risk factor for melanoma skin cancer. Posing as potential customers, we telephoned 94 indoor tanning businesses in six United States (U.S.) cities and requested pricing information. The price of a single tanning session ranged from $0 to $23, and was lower at facilities that of fered indoor tanning as a secondary service (mean $4.82 and free in 35%) than at tanning salons (mean $16.45). Session prices in salons could be as low as $1.50 wi...
Source: Journal of Public Health Policy - Category: Health Management Source Type: research
Cutaneous malignant melanoma (CM) is the leading cause of skin cancer –related mortality and accounts for approximately 1,250 deaths in Canada each year. It is also one of few cancers continuing to display rates of increasing incidence throughout the world. The past decade has brought significant growth in our understanding of the pathogenesis and clinical managemen t of CM. This evidence-based review synthesizes that knowledge, beginning with a review of the epidemiology and etiology of the disease followed by a broad review of the roles of diagnostic imaging in its management.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Continuing Medical Education Source Type: research
ConclusionsThe degree of tumor infiltrating B cell content is not associated with response to anti-PD-1 inhibitors in melanoma. PD-1 inhibitors cause tumor shrinkage in murine cancer models even when B cells are absent or are depleted. PD-1 inhibitors are likely to be active in patients with impaired B cell function, such as patients undergoing B cell depletion with drugs including rituximab for conditions such as B cell malignancies or autoimmune disorders.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
In this study, a croconaine dye molecule protected within a macrocycle has been prepared to be tested as photothermic agent. This pH sensitive croconaine dye allowed a selective NIR-light absorption only when the molecule was located in an acidic environment like the one found in intracellular vesicles; meanwhile it remained inactivated under physiological conditions. Results showed that photothermic heating produced upon 808 nm laser irradiation on mouse melanoma cells treated with this croconaine-based dye resulted in cell death which may be attributed to a dye uptake into acidic intracellular vesicles (i.e., endo...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
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