Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02273-8Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M. Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Antimicrobial Agents and Chemotherapy - April 15, 2024 Category: Microbiology Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Amenamevir for Treating Acyclovir-Resistant or Refractory Herpes Simplex Virus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Two Case Reports
Int J Antimicrob Agents. 2024 Apr 10:107169. doi: 10.1016/j.ijantimicag.2024.107169. Online ahead of print.NO ABSTRACTPMID:38608846 | DOI:10.1016/j.ijantimicag.2024.107169 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: L éo Sallée Laetitia Souchet David Boutolleau St éphanie Nguyen Source Type: research
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine & mdash;A Review
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine—A Review
Viruses doi: 10.3390/v16040593
Authors:
Ines Szotowska
Aleksandra Ledwoń
This review article describes the current knowledge about the use of antiviral chemotherapeutics in avian species, such as farm poultry and companion birds. Specific therapeutics are described in alphabetical order including classic antiviral drugs, such as acyclovir, abacavir, adefovir, amantadine, didanosine, entecavir, ganciclovir, interferon, lamivudine, penciclovir, famciclovir, oseltamivir, ribavirin, and zidovudine, repurposed drugs, such as iver...
Source: Viruses - April 12, 2024 Category: Virology Authors: Ines Szotowska Aleksandra Ledwo ń Tags: Review Source Type: research
Machine Learning Exploration of the Relationship Between Drugs and the Blood –Brain Barrier: Guiding Molecular Modification
ConclusionsThe machine learning models developed can accurately predict BBB permeability, and many drug molecules are likely to have increased BBB penetration if the number of Hydrogen Bond Donors and Acceptors are reduced. These findings suggest that molecular modifications can enhance the efficacy of CNS drugs and provide practical strategies for drug design and development. This is particularly relevant for improving drug penetration of the BBB.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
CNS Viral Infections —What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
AbstractNeurotropic viruses may cause meningitis, myelitis, encephalitis, or meningoencephalitis. These inflammatory conditions of the central nervous system (CNS) may have serious and devastating consequences if not treated adequately. In this review, we first summarize how neurotropic viruses can enter the CNS by (1) crossing the blood-brain barrier or blood-cerebrospinal fluid barrier; (2) invading the nose via the olfactory route; or (3) invading the peripheral nervous system. Neurotropic viruses may then enter the intracellular space of brain cells via endocytosis and/or membrane fusion. Antiviral drugs are currently ...
Source: CNS Drugs - April 5, 2024 Category: Neurology Source Type: research
A Case Report of Herpes Zoster After Botulinum Toxin Injections
Int Med Case Rep J. 2024 Mar 29;17:261-263. doi: 10.2147/IMCRJ.S457239. eCollection 2024.ABSTRACTThis case report presents a rare occurrence of herpes zoster (HZ) outbreak in a 50-year-old male following botulinum toxin (BTX) type A injections. The patient developed burning swollen lesions on the left forehead four days after receiving BTX injections. Physical examination revealed papules and erosions in a dermatomal distribution. He was diagnosed with HZ and promptly treated with oral acyclovir. The lesions resolved within two weeks without complications. Previous literature reports a few similar HZ outbreaks following ae...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Shadi Zari Source Type: research
Evaluation of Oral Health-Related Quality of Life in Patient with Herpes-Associated Erythema Multiforme: A Unique Case Report
CONCLUSION: The patient's physical, psychological, and social conditions showed improvement and returned to normal after 7 days of treatment. In conclusion, oral health is an important factor that can improve the quality of life of HAEM patient.PMID:38566932 | PMC:PMC10986623 | DOI:10.2147/IMCRJ.S456301 (Source: Herpes)
Source: Herpes - April 3, 2024 Category: Infectious Diseases Authors: Fitrah Utari Bakti Tenny Setiani Dewi Source Type: research
Evaluation of Oral Health-Related Quality of Life in Patient with Herpes-Associated Erythema Multiforme: A Unique Case Report
CONCLUSION: The patient's physical, psychological, and social conditions showed improvement and returned to normal after 7 days of treatment. In conclusion, oral health is an important factor that can improve the quality of life of HAEM patient.PMID:38566932 | PMC:PMC10986623 | DOI:10.2147/IMCRJ.S456301 (Source: Herpes)
Source: Herpes - April 3, 2024 Category: Infectious Diseases Authors: Fitrah Utari Bakti Tenny Setiani Dewi Source Type: research
Antiviral and synergistic effects of photo-energy with acyclovir on herpes simplex virus type 1 infection
Virology. 2024 Mar 31;595:110063. doi: 10.1016/j.virol.2024.110063. Online ahead of print.ABSTRACTThis experimental study aimed to evaluate the antiviral and synergistic effects of photoenergy irradiation on human herpes simplex virus type I (HSV-1) infection. We assessed viral replication, plaque formation, and relevant viral gene expression to examine the antiviral and synergistic effects of blue light (BL) with acyclovir treatment. Our results showed that daily BL (10 J/cm2) irradiation inhibited plaque-forming ability and decreased viral copy numbers in HSV-1-infected monkey kidney epithelial Vero cells and primary hum...
Source: Virology - April 2, 2024 Category: Virology Authors: Phil-Sun Oh Yeon-Hee Han SeokTae Lim Berwin Singh Swami Vetha Hwan-Jeong Jeong Source Type: research
Antiviral and synergistic effects of photo-energy with acyclovir on herpes simplex virus type 1 infection
Virology. 2024 Mar 31;595:110063. doi: 10.1016/j.virol.2024.110063. Online ahead of print.ABSTRACTThis experimental study aimed to evaluate the antiviral and synergistic effects of photoenergy irradiation on human herpes simplex virus type I (HSV-1) infection. We assessed viral replication, plaque formation, and relevant viral gene expression to examine the antiviral and synergistic effects of blue light (BL) with acyclovir treatment. Our results showed that daily BL (10 J/cm2) irradiation inhibited plaque-forming ability and decreased viral copy numbers in HSV-1-infected monkey kidney epithelial Vero cells and primary hum...
Source: Herpes - April 2, 2024 Category: Infectious Diseases Authors: Phil-Sun Oh Yeon-Hee Han SeokTae Lim Berwin Singh Swami Vetha Hwan-Jeong Jeong Source Type: research
