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Bioactivity and Pharmacodynamics of X002, a Follicle-stimulating Hormone-IgG4 Fc Fusion Protein
Comp Med. 2023 Apr 1. doi: 10.30802/AALAS-CM-22-000001. Online ahead of print.ABSTRACTCurrent follicle-stimulating hormone (FSH) drugs meet safety criteria but have suboptimal efficacy, poor patient compliance, and high cost. Alternative FSH-like drugs would help to meet the high market demand. Here, we evaluated X002, an FSH-Fc fusion protein, for bioactivity and half-life in vitro and in vivo. In all cases, the effects of X002 were compared with those of a commercially available short-acting FSH recombinant hormone. First, female Kunming mice (age, 21 to 24 d) were stimulated with pregnant mare serum gonadotropin (PMSG) ...
Source: Comparative Medicine - April 18, 2023 Category: Zoology Authors: Guili Xu Yi Yang Yunhui Liu Fang Chen Lihou Dong Deyou Wan Hongjie Li Cuima Yang Xin Gao Source Type: research

Bioactivity and Pharmacodynamics of X002, a Follicle-stimulating Hormone-IgG4 Fc Fusion Protein
Comp Med. 2023 Apr 1;73(2):145-52. doi: 10.30802/AALAS-CM-22-000001. Online ahead of print.ABSTRACTCurrent follicle-stimulating hormone (FSH) drugs meet safety criteria but have suboptimal efficacy, poor patient compliance, and high cost. Alternative FSH-like drugs would help to meet the high market demand. Here, we evaluated X002, an FSH-Fc fusion protein, for bioactivity and half-life in vitro and in vivo. In all cases, the effects of X002 were compared with those of a commercially available short-acting FSH recombinant hormone. First, female Kunming mice (age, 21 to 24 d) were stimulated with pregnant mare serum gonadot...
Source: Comparative Medicine - April 18, 2023 Category: Zoology Authors: Guili Xu Yi Yang Yunhui Liu Fang Chen Lihou Dong Deyou Wan Hongjie Li Cuima Yang Xin Gao Source Type: research

Appearance of a transparent protrusion containing two pairs of legs on the apodous ring preceding the anamorphic molt in a millipede, Niponia nodulosa
Arthropods gradually change their forms through repeated molting events during postembryonic development. Anamorphosis, i.e., segment addition during postembryonic development, is seen in some arthropod lineag... (Source: Frontiers in Zoology)
Source: Frontiers in Zoology - April 18, 2023 Category: Zoology Authors: Soma Chiyoda, Kohei Oguchi and Toru Miura Tags: Research Source Type: research

Social Learning of Innovations in Dynamic Predator-Prey Systems
The American Naturalist, Ahead of Print. (Source: The American Naturalist)
Source: The American Naturalist - April 18, 2023 Category: Zoology Authors: David W. Kikuchi Margaret W. Simon Source Type: research

Antimicrobial-Resistant < em > Enterobacterales < /em > Recovered from the Environment of Two Zoological Institutions Include Enterobacter cloacae Complex ST171 Producing KPC-4 Carbapenemase
Appl Environ Microbiol. 2023 Apr 17:e0025723. doi: 10.1128/aem.00257-23. Online ahead of print.ABSTRACTEnvironmental surfaces can serve as reservoirs for pathogens and antimicrobial-resistant (AMR) bacteria in healthcare settings. Although active surveillance programs are used in veterinary and human healthcare, unconventional settings like zoological facilities are often overlooked, even though antimicrobials are used to maintain the health of their animal collections. Here, we used electrostatic cloths to conduct active environmental surveillance over a 2-year period at two zoological institutions to determine contaminat...
Source: Applied and Environmental Microbiology - April 17, 2023 Category: Microbiology Authors: Gregory A Ballash Dimi A Mathys Sydnee M Feicht Dixie F Mollenkopf Amy L Albers Rachael J Adams Thomas E Wittum Source Type: research

What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals
Anim Cogn. 2023 Apr 17. doi: 10.1007/s10071-023-01776-z. Online ahead of print.ABSTRACTAll animals evolved from a single lineage of unicellular precursors more than 600 million years ago. Thus, the biological and genetic foundations for animal sensation, cognition and behavior must necessarily have arisen by modifications of pre-existing features in their unicellular ancestors. Given that the single-celled ancestors of the animal kingdom are extinct, the only way to reconstruct how these features evolved is by comparing the biology and genomic content of extant animals to their closest living relatives. Here, we reconstruc...
Source: Animal Cognition - April 17, 2023 Category: Zoology Authors: N úria Ros-Rocher Thibaut Brunet Source Type: research

Holobiont Evolution: Population Theory for the Hologenome
The American Naturalist, Ahead of Print. (Source: The American Naturalist)
Source: The American Naturalist - April 17, 2023 Category: Zoology Authors: Joan Roughgarden Source Type: research

Disease ecology of bats —the Canadian scene
Canadian Journal of Zoology, Ahead of Print. Bats are hosts to a range of pathogens, which include zoonotic pathogens and pathogens of conservation concern. Brock Fenton ’s research on bat ecology has always balanced clear communication of potential health risks associated with bats and the need to communicate these risks precisely to avoid unnecessary persecution of bats. Here, we integrate Brock’s work in the field of disease ecology with that of his students and collaborators and consider the potential advantages of studying disease ecology of bats within the Canadian context. The broad distribution of a few common ...
Source: Canadian Journal of Zoology - April 17, 2023 Category: Zoology Authors: Christina M. Davy Craig K.R. Willis Source Type: research

Calcitriol combined with fish oil in the diet of Chukar partridge can ameliorate laying performance by improving oviduct histomorphometry and functions
AbstractThe effects of calcitriol (CT) and/or fish oil (FO) on performance, oviposition time, sex ratio and morphology of the reproductive system of laying Chukar partridges were studied. Female (n = 48) and male (n = 16) partridges were used in a completely randomised design using a 2 × 2 factorial arrangement and were randomly allocated to either of four experimental treatments with four cage replicates of three females and one male each. Female birds received no FO (CON − FO) or were orally administered with 0.2 mL (0.24 g)/500 g body weight FO (CON + FO) or 0.2 mL solution containing 1...
Source: Journal of Animal Physiology and Animal Nutrition - April 15, 2023 Category: Zoology Authors: Arman Abdollahi, Amir Akhlaghi, Mohammad Javad Zamiri, Shahryar Kargar, Zarbakht Ansari Pirsaraei, Banafsheh Nasrollahi, Younes Kamali Tags: ORIGINAL ARTICLE Source Type: research