GSE242103 Cationic amphiphilic drug induced phospholipidosis and lysosomal dysgenesis during in vitro adipogenesis
Contributors : Deniz Bozdag ; Hande G Orhan ; Jeroen van Voorthuizen ; Jorke H Kamstra ; Sander LentzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investiga...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline
Toxicol Appl Pharmacol. 2024 Apr 19:116937. doi: 10.1016/j.taap.2024.116937. Online ahead of print.ABSTRACTSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investigated whether citalopram (CIT) and sertraline (SER) interfere with the process of adip...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Deniz Bozdag Jeroen van Voorthuizen Nikita Korpel Sander Lentz Hande Gurer-Orhan Jorke H Kamstra Source Type: research
Effectiveness of Antidepressants in Combination with Psychotherapy
This study reports the remission rates for the 14 most commonly prescribed single antidepressants (amitriptyline, bupropion, citalopram, desvenlafaxine, doxepin, duloxetine, escitalopram, fluoxetine, mirtazapine, nortriptyline, paroxetine, sertraline, trazodone, and venlafaxine) and a category named "Other" (other antidepressants/combination of antidepressants). The study used robust LASSO regressions to identify factors that affected remission rate and clinicians' selection of antidepressants. The selection bias in observational data was removed through stratification. We organized the data into 16,770 subgroups, of at le...
Source: Journal of Mental Health Policy and Economics - April 18, 2024 Category: Psychiatry Authors: Farrokh Alemi Tulay G Soylu Mary Cannon Conor McCandless Source Type: research
The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial
CONCLUSIONS: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.FUNDING: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) an...
Source: Psychological Medicine - April 17, 2024 Category: Psychiatry Authors: Jolanda Malamud Gemma Lewis Michael Moutoussis Larisa Duffy Jessica Bone Ramya Srinivasan Glyn Lewis Quentin J M Huys Source Type: research
The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial
CONCLUSIONS: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.FUNDING: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) an...
Source: Psychological Medicine - April 17, 2024 Category: Psychiatry Authors: Jolanda Malamud Gemma Lewis Michael Moutoussis Larisa Duffy Jessica Bone Ramya Srinivasan Glyn Lewis Quentin J M Huys Source Type: research
A Bell's Palsy Case Probably Related to Sertraline Use
Psychopharmacol Bull. 2024 Apr 4;54(2):51-52.NO ABSTRACTPMID:38601831 | PMC:PMC11003255 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - April 11, 2024 Category: Psychiatry & Psychology Authors: Mehmet Emin Ceylan Bar ış Önen Ünsalver Hatice Zeynep Ceylan Source Type: research
Insight into chemically reactive metabolites of aliphatic amine pollutants: A de novo prediction strategy and case study of sertraline
Environ Int. 2024 Apr 5;186:108636. doi: 10.1016/j.envint.2024.108636. Online ahead of print.ABSTRACTThe uncommon metabolic pathways of organic pollutants are easily overlooked, potentially leading to idiosyncratic toxicity. Prediction of their biotransformation associated with the toxic effects is the very purpose that this work focuses, to develop a de novo method to mechanistically predict the reactive toxicity pathways of uncommon metabolites from start aliphatic amine molecules, which employed sertraline triggered by CYP450 enzymes as a model system, as there are growing concerns about the effects on human health pose...
Source: Environment International - April 9, 2024 Category: Environmental Health Authors: Lingmin Jin Shiyang Cheng Wen Ding Jingru Huang Rudi van Eldik Li Ji Source Type: research
Insight into chemically reactive metabolites of aliphatic amine pollutants: A de novo prediction strategy and case study of sertraline
Environ Int. 2024 Apr 5;186:108636. doi: 10.1016/j.envint.2024.108636. Online ahead of print.ABSTRACTThe uncommon metabolic pathways of organic pollutants are easily overlooked, potentially leading to idiosyncratic toxicity. Prediction of their biotransformation associated with the toxic effects is the very purpose that this work focuses, to develop a de novo method to mechanistically predict the reactive toxicity pathways of uncommon metabolites from start aliphatic amine molecules, which employed sertraline triggered by CYP450 enzymes as a model system, as there are growing concerns about the effects on human health pose...
Source: Environment International - April 9, 2024 Category: Environmental Health Authors: Lingmin Jin Shiyang Cheng Wen Ding Jingru Huang Rudi van Eldik Li Ji Source Type: research
