Clinicopathological features, prognosis, and fertility outcomes in Chinese Han women treated for ovarian yolk sac tumor: A retrospective case series study from two tertiary-care academic medical centers
Conclusions: The diagnosis of YST of childbearing age is very rare. Because the failure of primary treatment is related to the residual disease after salvage surgery, the fertility and survival results of patients undergoing fertility-preserving surgery are promising. (Source: Medicine)
Source: Medicine - July 22, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Immature ovarian teratoma in childhood: Case report of successful management of a monster mass in a preschool girl
CONCLUSION: In spite of immature ovarian teratomas having aggressive behaviour and lethal outcome, a high degree of suspicion and timely management can translate into a very good eventual prognosis.PMID:35846860 | PMC:PMC9283807 | DOI:10.1016/j.amsu.2022.104147 (Source: Annals of Medicine)
Source: Annals of Medicine - July 18, 2022 Category: Internal Medicine Authors: Pradeep Kajal Namita Bhutani Kirti Saini Preeti Kadian Source Type: research

Imaging Findings and Clinical Analysis of Primary Intracranial Pure Yolk Sac Tumors in Children and Adolescents: A Retrospective Study from China [PEDIATRICS]
CONCLUSIONS: There are some relatively specific imaging findings of primary intracranial yolk sac tumors that could assist in their diagnosis. Surgery combined with radiation therapy and/or chemotherapy can achieve a better prognosis. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - July 7, 2022 Category: Radiology Authors: Dai, W., Liu, H., Chen, Y., Chen, Z. Tags: PEDIATRICS Source Type: research

An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1
We report an unusual enteric variant of ovarian YST in a 28-yr-old woman associated with a germline PV c.901C>T (p.Gln301Ter) in exon 7 of DICER1, accompanied by a somatic (YST-only) hotspot mutation: c.5437G>A, p.E1813K. To our knowledge, this is the first report of an ovarian germ cell tumor associated with a germline DICER1 PV. We review other reported cases of ovarian germ cell tumor with DICER1 PVs and discuss the differential diagnosis of this unusual variant of YST which was originally diagnosed as a mucinous adenocarcinoma. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - June 29, 2022 Category: Pathology Tags: Pathology of the Upper Tract: Case Reports Source Type: research

Cancers, Vol. 14, Pages 3180: Imaging of Pediatric Testicular and Para-Testicular Tumors: A Pictural Review
cou Le Pointe Pre- and post-pubertal testicular tumors are two distinct entities in terms of epidemiology, diagnosis and treatment. Most pre-pubertal tumors are benign; the most frequent are teratomas, and the most common malignant tumors are yolk-sac tumors. Post-pubertal tumors are similar to those found in adults and are more likely to be malignant. Imaging plays a pivotal role in the diagnosis, staging and follow-up. The appearance on ultrasonography (US) is especially helpful to differentiate benign lesions that could be candidates for testis-sparing surgery from malignant ones that require radical orchidectomy. S...
Source: Cancers - June 29, 2022 Category: Cancer & Oncology Authors: Anne-Laure Hermann Aurore L ’Herminé-Coulomb Sabine Irtan Georges Audry Liesbeth Cardoen Herv é J. Brisse Saskia Vande Perre Hubert Ducou Le Pointe Tags: Review Source Type: research

De-differentiated metastatic adenosquamous carcinoma arising from germ cell tumor in the brain and spine
AbstractIntracranial germ cell tumors have an estimated incidence of 0.4 –3.4% in the Western Hemisphere. Patients can present with a variety of differing clinical signs and symptoms including headache, nausea/vomiting, hydrocephalus, obtundation, pyramidal tract signs, ataxia, and hypothalamic/pituitary dysfunction. Rarely germ cell tumors can transform into alternati ve malignancy. In these cases, treatment options may be difficult. Metastasis to the brain is not uncommon in germ cell tumors and is frequently reported within the pineal region; however, they are less common intraventricularly, within the posterior fossa...
Source: Acta Neurochirurgica - June 28, 2022 Category: Neurosurgery Source Type: research

Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group
CONCLUSIONS: In pediatric and adolescent patients with a confirmed final diagnosis of ovarian germ cell malignancy, intra-operative frozen section diagnosis is not reliable to inform the extent of surgical staging required. Central review by an expert germ cell tumor pathologist provides important additional information to guide therapy.PMID:35750503 | DOI:10.1016/j.ygyno.2022.06.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - June 24, 2022 Category: Cancer & Oncology Authors: B J Dicken D F Billmire B Rich F K Hazard M Nu ño M Krailo N Fallahazad F Pashankar F Shaikh A L Frazier Source Type: research

Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group
CONCLUSIONS: In pediatric and adolescent patients with a confirmed final diagnosis of ovarian germ cell malignancy, intra-operative frozen section diagnosis is not reliable to inform the extent of surgical staging required. Central review by an expert germ cell tumor pathologist provides important additional information to guide therapy.PMID:35750503 | DOI:10.1016/j.ygyno.2022.06.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - June 24, 2022 Category: Cancer & Oncology Authors: B J Dicken D F Billmire B Rich F K Hazard M Nu ño M Krailo N Fallahazad F Pashankar F Shaikh A L Frazier Source Type: research

Post-pubertal ovarian yolk sac tumor with unusual follicular growth pattern, simulating struma ovarii
AbstractYolk sac tumors (YST), formerly known as endodermal sinus tumors, are uncommon ovarian neoplasms. They are most common in the second and third decades of life and are rare in women older than 39  years of age. YST exhibit various histologic patterns. Microfollicular pattern resembling thyroid tissue has not been reported. We introduce here a case of yolk sac tumor in a 39 y/o female, presented with pelvic masses and high level of serum Alpha-fetoprotein (Alpha Fetoprotein) (>  1000 IU/ml). The patient underwent left salpingo-oophorectomy. On microscopic study, morphologic findings demonstrated a neoplasm com...
Source: International Cancer Conference Journal - June 15, 2022 Category: Cancer & Oncology Source Type: research

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research