Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Med Mol Morphol. 2023 Nov 22. doi: 10.1007/s00795-023-00374-9. Online ahead of print.ABSTRACTSerpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely c...
Source: Molecular Medicine - November 22, 2023 Category: Molecular Biology Authors: Toshiki Anami Yuki Ibe Lianbo Li Yoshihiro Komohara Hiroki Hirao Mamoru Harada Hiromu Yano Yukio Fujiwara Takanobu Motoshima Junji Yatsuda Taizo Hibi Tomomi Kamba Source Type: research
Overexpression of SerpinB9 in non-seminomatous germ cell tumors
AbstractSerpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely correlated with the number of tumor-infiltrating CD8-positive cells. In addition, yolk...
Source: Medical Molecular Morphology - November 22, 2023 Category: Molecular Biology Source Type: research
Administration of a glypican ‐3 peptide increases the infiltration and cytotoxicity of CD8+ T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS/STING signaling
ConclusionsThese data indicated that GPC3 peptide-specific CD8+ T cells had potent antitumor activity against TYST tumor, particularly for combined treatment with the peptide, which was partially dependent on the intratumoral cGAS/STNG signaling. GPC3 peptide vaccine may be valuable for the combination treatment of TYST. (Source: Cancer Medicine)
Source: Cancer Medicine - November 21, 2023 Category: Cancer & Oncology Authors: Junfeng Zhao,
Le Qin,
Guorong He,
Tiancheng Xie,
Guanghui Hu,
Furan Wang,
Hongji Zhong,
Jianming Zhu,
Yunfei Xu Tags: RESEARCH ARTICLE Source Type: research
Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type: A Case Report with Summary of Prior Published Cases
CONCLUSION: We report a testicular mixed teratoma and yolk sac tumor, prepubertal type along with summary of prior published cases. There is only one report describing this combination of mature teratoma with yolk sac tumor in the prepubertal testis.PMID:37946365 | DOI:10.1080/15513815.2023.2279132 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 10, 2023 Category: Pathology Authors: Md Mohin Soumya Dey Raktim Ray Firdous Wasim Sk Oindrila Das Uttara Chatterjee Source Type: research
Survival outcomes and establishment of a novel risk stratification system in patients with ovarian yolk sac tumors
CONCLUSION: This risk stratification system based on tumor stage and the interval between treatment and normalization of AFP may help to guide clinical management by dividing OYST patients into three risk groups.PMID:37865050 | DOI:10.1016/j.ygyno.2023.10.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 21, 2023 Category: Cancer & Oncology Authors: Sijian Li Xinyue Zhang Tianyu Zhang Rundong Zhang Dongyan Cao Yang Xiang Jiaxin Yang Source Type: research
Survival outcomes and establishment of a novel risk stratification system in patients with ovarian yolk sac tumors
CONCLUSION: This risk stratification system based on tumor stage and the interval between treatment and normalization of AFP may help to guide clinical management by dividing OYST patients into three risk groups.PMID:37865050 | DOI:10.1016/j.ygyno.2023.10.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 21, 2023 Category: Cancer & Oncology Authors: Sijian Li Xinyue Zhang Tianyu Zhang Rundong Zhang Dongyan Cao Yang Xiang Jiaxin Yang Source Type: research
Survival outcomes and establishment of a novel risk stratification system in patients with ovarian yolk sac tumors
CONCLUSION: This risk stratification system based on tumor stage and the interval between treatment and normalization of AFP may help to guide clinical management by dividing OYST patients into three risk groups.PMID:37865050 | DOI:10.1016/j.ygyno.2023.10.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 21, 2023 Category: Cancer & Oncology Authors: Sijian Li Xinyue Zhang Tianyu Zhang Rundong Zhang Dongyan Cao Yang Xiang Jiaxin Yang Source Type: research
Survival outcomes and establishment of a novel risk stratification system in patients with ovarian yolk sac tumors
CONCLUSION: This risk stratification system based on tumor stage and the interval between treatment and normalization of AFP may help to guide clinical management by dividing OYST patients into three risk groups.PMID:37865050 | DOI:10.1016/j.ygyno.2023.10.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 21, 2023 Category: Cancer & Oncology Authors: Sijian Li Xinyue Zhang Tianyu Zhang Rundong Zhang Dongyan Cao Yang Xiang Jiaxin Yang Source Type: research
Survival outcomes and establishment of a novel risk stratification system in patients with ovarian yolk sac tumors
CONCLUSION: This risk stratification system based on tumor stage and the interval between treatment and normalization of AFP may help to guide clinical management by dividing OYST patients into three risk groups.PMID:37865050 | DOI:10.1016/j.ygyno.2023.10.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 21, 2023 Category: Cancer & Oncology Authors: Sijian Li Xinyue Zhang Tianyu Zhang Rundong Zhang Dongyan Cao Yang Xiang Jiaxin Yang Source Type: research
Alveolar macrophages in lung cancer: opportunities challenges
Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose foreign particles, defend the host against pathogens, recycle surfactant, and promptly respond to inhaled noxious stimuli. The behavior of AMs is tightly dependent on the environmental cues whereby infection, chronic inflammation, and associated metabolic changes can repolarize their effector functions in the lungs. Several factors within the tumor microenvironment can re-educate AMs, resulting in tumor growth, and reducing immune ...
Source: Frontiers in Immunology - September 26, 2023 Category: Allergy & Immunology Source Type: research
Clinical characteristics and prognostic models of gonadal and extra-gonadal yolk sac tumors: a population-based analysis in children and adolescents
ConclusionsOur study revealed that age, gender, and primary site were found to be the most important predictors of the overall survival of pediatric YST, providing crucial epidemiological information for clinical management. (Source: World Journal of Urology)
Source: World Journal of Urology - September 25, 2023 Category: Urology & Nephrology Source Type: research
Safety and feasibility of resection after neoadjuvant chemotherapy for mediastinal yolk sac tumor
Asian J Surg. 2023 Sep 20:S1015-9584(23)01445-8. doi: 10.1016/j.asjsur.2023.09.050. Online ahead of print.NO ABSTRACTPMID:37739897 | DOI:10.1016/j.asjsur.2023.09.050 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 22, 2023 Category: Surgery Authors: Yongjiang Chen Chao Yang Can Huang Shuben Li Source Type: research
Safety and feasibility of resection after neoadjuvant chemotherapy for mediastinal yolk sac tumor
Asian J Surg. 2023 Sep 20:S1015-9584(23)01445-8. doi: 10.1016/j.asjsur.2023.09.050. Online ahead of print.NO ABSTRACTPMID:37739897 | DOI:10.1016/j.asjsur.2023.09.050 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 22, 2023 Category: Surgery Authors: Yongjiang Chen Chao Yang Can Huang Shuben Li Source Type: research
Testicular tumours in children: a single-centre experience
CONCLUSION: Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.PMID:37721303 | DOI:10.4103/singaporemedj.SMJ-2021-380 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sajid Ali Tariq Latif Muhammad Ali Sheikh Shazia Perveen Muhammad Bilal Albash Sarwar Source Type: research
