The clinical features and prognostic outcomes of primary mediastinal yolk sac tumors: A retrospective analysis of 15 rare cases from multiple centers
In this study, we aimed to provide further information relating to this rare malignancy in order to facilitate the creation of more specific clinical guidelines for the diagnosis and treatment of patients with PMYSTs. In this retrospective study, we recruited 15 patients who had been diagnosed with PMYST from four medical institutions to create a population-based cohort. We then used Kaplan-Meier analysis and the log-rank test to investigate and compare overall survival (OS) and progression-free survival (PFS). A total of 15 cases were identified. The mean age was 27.3 years (range: 19–34 years). The estimated ...
Source: Medicine - July 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Rupture and hemorrhage of a seminoma mixed with yolk sac tumors in 46XY partial gonadal dysgenesis: a case report and literature review
46XY partial gonadal dysgenesis (PGD) is a rare subtype of disorder of sex development (DSD). 46YY PGD is a congenital disease with atypical chromosomal, gonadal, or anatomical sex development. The patient in ... (Source: BMC Surgery)
Source: BMC Surgery - July 3, 2021 Category: Surgery Authors: Rui Lin, Nanbin Liu, Xiuyan Wang, Xuyou Zhu, Daojing Huang and Baomin Shi Tags: Case report Source Type: research

SMARCB1 (INI1)–Deficient Sinonasal Carcinoma With Yolk Sac Tumor Differentiation: Case Report and Review of the Literature
SMARCB1 (INI1)–deficient sinonasal carcinoma is a recently described primary neoplasm of the sinonasal tract that occurs infrequently and displays aggressive clinical behavior. Classic histopathologic findings of INI1-deficient sinonasal carcinoma include sheets and nests of basaloid tumors cells with a monomorphic appearance. Variable amounts of rhabdoid and glandular differentiation have been reported. Diagnosis of this lesion can be challenging because of significant morphologic and immunohistochemical overlap between other primary lesions of the sinonasal tract, including basaloid and other nonkeratinizing squamous c...
Source: Pathology Case Reviews - July 1, 2021 Category: Pathology Tags: Case Reviews Source Type: research

Role of Radiotherapy in Recurrent Intra-Abdominal Yolk Sac Tumor
Yolk sac tumor (YST) is a rare malignant germ cell tumor with no appropriate treatment strategy to date. However, patients are treated on a case-to-case basis as per various case reports that have been published. Here, we present a case of 27-year-old female patient who presented to us with chief complaints of severe abdominal pain associated with leucorrhea. She previously had a similar pain episode, which was then evaluated by a multidisciplinary team. She was diagnosed with YST. After that, she underwent 6 cycles of chemotherapy, but there was no improvement. Then the medical oncologist referred her to performed radioth...
Source: Case Reports in Oncology - June 28, 2021 Category: Cancer & Oncology Source Type: research

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features
Testicular tumors are incredibly diverse and one of the most challenging areas in surgical pathology. Because of the rarity and overlapping features with numerous entities occurring in the testis and paratestis, these tumors pose a diagnostic challenge even to the most experienced general pathologists. In 2016, the latest “World Health Organization (WHO) classification of testicular tumors” was released, which incorporated several updates to the previous 2004 classification system. These updates involved several entities, including germ cell tumors, sex cord-stromal tumors, tumors containing both germ cells and sex-cor...
Source: Advances in Anatomic Pathology - June 24, 2021 Category: Pathology Tags: Review Articles Source Type: research