Adjuvant and post-surgical treatment in non-epithelial ovarian cancer
This article discusses the importance of selecting the adjuvant treatment approach most suitable to the patients' surgical and pathological stages, thereby safeguarding patient outcomes.PMID:34493450 | DOI:10.1016/j.bpobgyn.2021.06.001 (Source: Cell Research)
Source: Cell Research - September 8, 2021 Category: Cytology Authors: Aya El Helali Gladys Shuk Tak Kwok Ka Yu Tse Source Type: research

Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options
AbstractSMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with y...
Source: Head and Neck Pathology - August 21, 2021 Category: Pathology Source Type: research

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features
Mediastinal germ cell tumors (MGCTs) are the most common extragonadal germ cell tumors (GCTs) and most often arise in the anterior mediastinum with a male predilection. MGCTs also have a predilection for patients with Klinefelter syndrome and possibly other genetic conditions. MGCTs, as GCTs at other extragonadal sites, are thought to arise from germ cells improperly retained during migration along the midline during embryogenesis. Similar to their counterparts in the testes, MGCTs are classified into seminomatous and nonseminomatous GCTs. Seminomatous MGCT represents pure seminoma, whereas nonseminomatous MGCTs encompass ...
Source: Advances in Anatomic Pathology - August 20, 2021 Category: Pathology Tags: Review Articles Source Type: research

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP-positive metastasis. Low-level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.PMID:34363325 | DOI:10.1002/cjp2.237 (Source: Cell Research)
Source: Cell Research - August 7, 2021 Category: Cytology Authors: Viktor Reiswich Natalia Gorbokon Andreas M Luebke Eike Burandt Anne Menz Martina Kluth Claudia Hube-Magg Corinna Wittmer S ören Weidemann Christoph Fraune Katharina M öller Patrick Lebok Guido Sauter Ronald Simon Ria Uhlig Waldemar Wilczak Frank Jacobse Source Type: research

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP-positive metastasis. Low-level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.PMID:34363325 | DOI:10.1002/cjp2.237 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - August 7, 2021 Category: Cancer & Oncology Authors: Viktor Reiswich Natalia Gorbokon Andreas M Luebke Eike Burandt Anne Menz Martina Kluth Claudia Hube-Magg Corinna Wittmer S ören Weidemann Christoph Fraune Katharina M öller Patrick Lebok Guido Sauter Ronald Simon Ria Uhlig Waldemar Wilczak Frank Jacobse Source Type: research

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP-positive metastasis. Low-level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.PMID:34363325 | DOI:10.1002/cjp2.237 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - August 7, 2021 Category: Cancer & Oncology Authors: Viktor Reiswich Natalia Gorbokon Andreas M Luebke Eike Burandt Anne Menz Martina Kluth Claudia Hube-Magg Corinna Wittmer S ören Weidemann Christoph Fraune Katharina M öller Patrick Lebok Guido Sauter Ronald Simon Ria Uhlig Waldemar Wilczak Frank Jacobse Source Type: research

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP-positive metastasis. Low-level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.PMID:34363325 | DOI:10.1002/cjp2.237 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - August 7, 2021 Category: Cancer & Oncology Authors: Viktor Reiswich Natalia Gorbokon Andreas M Luebke Eike Burandt Anne Menz Martina Kluth Claudia Hube-Magg Corinna Wittmer S ören Weidemann Christoph Fraune Katharina M öller Patrick Lebok Guido Sauter Ronald Simon Ria Uhlig Waldemar Wilczak Frank Jacobse Source Type: research

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP-positive metastasis. Low-level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.PMID:34363325 | DOI:10.1002/cjp2.237 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - August 7, 2021 Category: Cancer & Oncology Authors: Viktor Reiswich Natalia Gorbokon Andreas M Luebke Eike Burandt Anne Menz Martina Kluth Claudia Hube-Magg Corinna Wittmer S ören Weidemann Christoph Fraune Katharina M öller Patrick Lebok Guido Sauter Ronald Simon Ria Uhlig Waldemar Wilczak Frank Jacobse Source Type: research

Multimodal Treatment of Children With Sacrococcygeal Yolk Sac Tumor: Retrospective Analysis of Clinicopathology Characteristics and Relapse-free Survival
The aim of the study was to explore the clinicopathologic characteristics of sacrococcygeal yolk sac tumor (SYST) associated with relapse and the role of sensitivity to neoadjuvant chemotherapy in predicting outcome. The authors investigated prognostic factors of age, stage, initial tumor size, pathologic response to neoadjuvant chemotherapy, and alfa fetoprotein. A total of 26 patients with SYST were enrolled. Neoadjuvant chemotherapy was administered to 20 cases. Six patients underwent resection as initial therapy. Recurrence occurred in 12 patients. Nine patients with specimens exhibiting no malignant component after ch...
Source: Journal of Pediatric Hematology Oncology - August 1, 2021 Category: Hematology Tags: Online Articles: Original Articles Source Type: research