Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis
CONCLUSIONS: Our population-based evidence showed that MMGCT had worse prognosis in older children and adolescents. Choriocarcinomas and embryonal carcinomas had the worst prognosis. Surgery can prolong survival time. Chemotherapy and radiotherapy were not associated with improved prognosis.PMID:37062232 | DOI:10.1016/j.jss.2023.03.018 (Source: Cell Research)
Source: Cell Research - April 16, 2023 Category: Cytology Authors: Peng Wu Yicheng Yang Zhechen Yu Lingling Zhao Shaoguang Feng Source Type: research
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
AbstractTumor markers in CNS germ cell tumors (GCTs) include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP), which have significant diagnostic implications, as elevation of either one leads to clinical diagnosis of non-germinomatous GCTs without histopathological confirmation, justifying intensified chemotherapy and irradiation. The current study, based on an international cohort of histopathologically verified GCTs that underwent biopsy (n = 85) or resection (n = 76), sought to better define the clinical role and prognostic significance of tumor markers from serum and CSF in this challenging patient po...
Source: Brain Tumor Pathology - March 30, 2023 Category: Neurology Source Type: research
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options
CONCLUSIONS: In summary, this study offers a novel CLDN6-ADC to target GCT. Additionally, this study presents novel pharmacological inhibitors blocking FGF, VGF, PDGF, mTOR, CHEK1, AURKA, or PARP signaling for the treatment of (refractory) YST patients. Finally, this study shed light on the mechanisms of therapy resistance in YST.PMID:36991316 | DOI:10.1186/s10020-023-00636-3 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2023 Category: Molecular Biology Authors: Margaretha A Skowron Mara Kotthoff Felix Bremmer Katja Ruhnke Fatma Parmaksiz Annika Richter Stefan K üffer Kirsten Reuter-Jessen Stella Pauls Anja Stefanski Philipp Str öbel Kai St ühler Daniel Nettersheim Source Type: research
A case of vasculogenic mesenchymal tumor in the mediastinum: whole-exome sequencing reveals origin from pre-existing germ cell tumor
AbstractVasculogenic mesenchymal tumor (VMT), a primitive mesenchymal neoplasm enriched by various-sized atypical vessels, is a new entity that develops in mediastinal germ cell tumors (GCTs) with yolk sac tumor (YST) components after chemotherapy. Notably, patients with VMT in the residual GCT have increased risk of developing sarcomas or hematopoietic malignancies. Here, we report a late-teenage male patient with residual teratoma and high-grade VMT after chemotherapy for a mediastinal mixed GCT, including YST. Whole-exome sequencing revealed biallelic inactivation ofTP53 and extensive copy number alterations that sugges...
Source: Virchows Archiv - March 21, 2023 Category: Pathology Source Type: research
Vaginal yolk sac tumors in infants and children: A case report and literature review
Oncol Lett. 2023 Feb 8;25(3):120. doi: 10.3892/ol.2023.13706. eCollection 2023 Mar.ABSTRACTA vaginal yolk sac tumor (YST) is a rare malignant germ cell tumor for infants and children, and it has been >50 years since the first case was reported. The treatment strategy has changed markedly in the past 50 years, from radical surgical treatment to conservative surgery combined with chemotherapy, and then to combined chemotherapy alone. The present study reports the case of a primary vaginal YST in a 13-month-old girl that was successfully treated by tumor resection combined with chemotherapy. The clinical symptoms, imaging ...
Source: Oncology Letters - March 13, 2023 Category: Cancer & Oncology Authors: Zhongli Ma Canyu Li Source Type: research
Case report and review of literature: immature teratoma with islets of a yolk-sac tumour: could it be omitted for years?
J Obstet Gynaecol. 2023 Dec;43(1):2182673. doi: 10.1080/01443615.2023.2182673.NO ABSTRACTPMID:36877134 | DOI:10.1080/01443615.2023.2182673 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - March 6, 2023 Category: OBGYN Authors: Žana Stanić Zlatko Hrgovi ć Rajko Fure š Anis Cerovac Source Type: research
Antitumor therapy for breast cancer: Focus on tumor ‐associated macrophages and nanosized drug delivery systems
ConclusionTAMs play an important role in the progression of BC, and targeting TAMs is a promising strategy for BC therapy. In particular, NDDSs targeting TAMs have unique advantages and are potential treatments for BC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 16, 2023 Category: Cancer & Oncology Authors: Cuiping Zhan,
Ying Jin,
Xinzhi Xu,
Jiangbo Shao,
Chunxiang Jin Tags: REVIEW Source Type: research
Metastatic yolk sac tumor masquerading as multifocal hepatocellular carcinoma in a young adult: A case report
We present a case of a young adolescent who presented with bleeding per rectum abdominal pain and multiple liver lesions. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 3, 2023 Category: General Medicine Authors: Kamran Mushtaq,
Muhammad Umair Khan,
Deema Al Soub,
Sheija Mary Koshy,
Maher Petkar,
Khalid Mohsin Al Ejji Tags: CASE REPORT Source Type: research
Yolk sac tumor and dysgerminoma in the left gonad following gonadoblastoma in the right gonad in a 46,XY DSD with a novel SRY missense mutation: a case report
Approximately 10 –15% of 46,XY disorders of sex development (DSDs) have an SRY mutation residing in the high mobility group (HMG) domain. Here, we present a case of 46,XY DSD caused by a novel missense mutation... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - January 24, 2023 Category: OBGYN Authors: Chengxiu Xie, Jian Cai, Nan Li, Ping Hua, Zexuan Yang, Xia Yu, Dongmei Tang, Yu Hu and Qingsong Liu Tags: Case report Source Type: research
