Carcinosarcoma of the stomach: four cases that expand the morphologic spectrum of gastric cancer with a primitive phenotype
We describe four examples with a focus on the characterization of the epithelial components and the histogenetic implications for this unique tumor. All patients were men aged 40 –79 years. All patients developed metastatic disease, and three of them died 4–19 months after the diagnosis. Sarcomatous elements included poorly differentiated spindle cell sarcoma without distinctive differentiation (n = 4), chondrosarcoma (n = 2), and rhabdomyosarcoma (n = 1). In two cases, the sarcomatous component was recognized only in metastatic lesions. Notably, carcinomatous components were characterized by multilineage...
Source: Virchows Archiv - March 3, 2022 Category: Pathology Source Type: research

Cancers, Vol. 14, Pages 1127: Very Late Recurrence in Germ Cell Tumor of the Testis: Lessons and Implications
Conclusions. Patients with LR > 5 years tend to harbor nonseminoma (with yolk sac tumor and or teratoma). Among these patients, a majority who did not undergo surgery to remove residual disease after chemotherapy developed somatic transformation and succumbed to their LR. (Source: Cancers)
Source: Cancers - February 23, 2022 Category: Cancer & Oncology Authors: Joseph A. Moore Rebecca S. Slack Michael J. Lehner Matthew T. Campbell Amishi Y. Shah Miao Zhang Charles C. Guo John F. Ward Jose A. Karam Christopher G. Wood Louis L. Pisters Shi-Ming Tu Tags: Article Source Type: research

Surgical management and outcomes for stage 1 malignant ovarian germ cell tumours: A UK multicentre retrospective cohort study
CONCLUSIONS: Across all histologies and ages, the absence of surgical staging did not impact upon disease free or overall survival in this cohort. This study also raises the possibility of a role for ovarian cystectomy in immature teratoma. These findings warrant investigation in larger prospective studies.PMID:35192975 | DOI:10.1016/j.ejogrb.2022.02.013 (Source: Reproductive Biology)
Source: Reproductive Biology - February 22, 2022 Category: Reproduction Medicine Authors: Radha Graham Nicola D MacDonald Michelle Lockley Rowan Miller John Butler Krithika Murali Shah-Jalal Sarker Susana Banerjee Sara Stoneham Jonathan Shamash Viola Liberale Daniel M Berney Claire Newton Source Type: research

Surgical management and outcomes for stage 1 malignant ovarian germ cell tumours: A UK multicentre retrospective cohort study
CONCLUSIONS: Across all histologies and ages, the absence of surgical staging did not impact upon disease free or overall survival in this cohort. This study also raises the possibility of a role for ovarian cystectomy in immature teratoma. These findings warrant investigation in larger prospective studies.PMID:35192975 | DOI:10.1016/j.ejogrb.2022.02.013 (Source: Reproductive Biology)
Source: Reproductive Biology - February 22, 2022 Category: Reproduction Medicine Authors: Radha Graham Nicola D MacDonald Michelle Lockley Rowan Miller John Butler Krithika Murali Shah-Jalal Sarker Susana Banerjee Sara Stoneham Jonathan Shamash Viola Liberale Daniel M Berney Claire Newton Source Type: research

Pediatric Primary Yolk Sac Tumour of the Kidney: Recommendations for Pretreatment Diagnosis
Conclusion: Renal YST may be indistinguishable from Wilms tumor clinically and radiologically. For pre-biopsy chemotherapy management protocols, serum tumor markers such as AFP may be recommended to identify the occasional GCT, including YST. Pre-chemotherapy needle biopsies may lead to misdiagnosis, and may require confirmation by an experienced pathologist or central review.PMID:35188860 | DOI:10.1080/15513815.2022.2042631 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - February 21, 2022 Category: Pathology Authors: Shilpi Thakur Aanchal Kakkar Manisha Jana Prasenjit Das Sandeep P Agarwala Venkateswaran K Iyer Source Type: research

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature
One hundred fifty yolk sac tumors (YSTs) of the ovary in patients from 1 to 61 (mean: 21.5) years of age are described; 75% of the patients were in the second and third decades and only 1 was above 50 years of age. The clinical manifestations were typically related to a fast-growing adnexal mass; endocrine manifestations (hirsutism) were present in only 2 cases. The tumors were all unilateral and 70% were ≥15 cm; an associated dermoid cyst was present in 20 cases. The tumors were solid and cystic in 57% of the cases, 25% were multicystic, and 18% uniformly solid. The solid tissue was typically tan to pink or yellow and...
Source: The American Journal of Surgical Pathology - February 17, 2022 Category: Pathology Tags: Original Articles Source Type: research

Spectrum of Germ Cell Tumor (GCT): 5 Years ’ Experience in a Tertiary Care Center and Utility of OCT4 as a Diagnostic Adjunct
AbstractGerm cell tumors (GCT) are an intriguing group of neoplasm having myriad clinical and morphological presentation. More and more transcription factors are being evaluated for identification of same. To study the spectrum of GCTs in a tertiary care center and the use of a stem cell marker OCT4 as a diagnostic adjunct, a retrospective 5-year (2008 –2013) study was carried out. Immunohistochemistry (IHC) with OCT4 was performed on all cases and IHC for α feto protein (AFP), CD30, and epithelial membrane antigen (EMA) as per requirement. Cohort included 73 cases (23 males and 50 females). Testicular and ovarian GCTs ...
Source: Indian Journal of Surgical Oncology - February 17, 2022 Category: Cancer & Oncology Source Type: research

Surgical management and outcomes for stage 1 malignant ovarian germ cell tumours: a UK multicentre retrospective cohort study
Malignant ovarian germ cell tumours (MOGCTs) are rare with a yearly-adjusted incidence of 3.7 per million [1]. These account for 1-2% of all ovarian malignancies in Europe [2 –4] and comprise the histological subtypes: dysgerminoma, yolk sac tumour, mixed germ cell tumour, immature teratoma (IT) and embryonal carcinoma [5,3]. Fertility sparing surgery is a safe and effective strategy with excellent five year survival of 95% for stage one tumours [2,6]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 16, 2022 Category: OBGYN Authors: Radha Graham, Nicola D MacDonald, Michelle Lockley, Rowan Miller, John Butler, Krithika Murali, Shah-Jalal Sarker, Susana Banerjee, Sara Stoneham, Jonathan Shamash, Viola Liberale, Daniel M Berney, Claire Newton Source Type: research

Molecules, Vol. 27, Pages 1211: Anti-Tumor Active Isopropylated Fused Azaisocytosine-Containing Congeners Are Safe for Developing Danio rerio as Well as Red Blood Cells and Activate Apoptotic Caspases in Human Breast Carcinoma Cells
anke New isopropylated fused azaisocytosine-containing congeners (I–VI) have previously been reported as promising anticancer drug candidates, so further research on these molecules in the preclinical development phase is fully justified and necessary. For this reason, in the present paper, we assess the toxicity/safety profiles of all the compounds using Danio rerio and red blood cell models, and examine the effect of the most selective congeners on the activation of apoptotic caspases in cancer and normal cells. In order to evaluate the effect of each molecule on the development of zebrafish embryos/lar...
Source: Molecules - February 11, 2022 Category: Chemistry Authors: Ma łgorzata Sztanke Jolanta Rzymowska Krzysztof Sztanke Tags: Article Source Type: research

Post-treatment Residual Clinicopathological Outcomes in Testicular Germ Cell Tumours
AbstractSurgical resection is a generally accepted treatment for residual masses after chemotherapy for metastatic testicular germ cell tumour (GCT). About half the patients have necrosis in post-chemotherapy residual masses, whereas rest have viable tumour and teratoma. The likelihood of leaving behind teratoma with its subsequent complications such as growing teratoma syndrome necessitates resection outweighing its surgical complications. Ours is a retrospective observational study and aims at assessing post-chemotherapy residual masses in testicular GCTs and to predict importance of teratomatous and non-seminomatous com...
Source: Indian Journal of Surgical Oncology - January 29, 2022 Category: Cancer & Oncology Source Type: research

Yolk Sac Tumor in the Anterior Mediastinum Presenting as Acute Pericarditis
CONCLUSIONS The discussed case shows the rare presentation of an anterior mediastinal mass with acute pericarditis. This emphasizes the importance of a thorough review of systems and critical analysis of every sign and symptom at the time of initial presentation, which helps the physician to obtain appropriate imaging studies early in the course, leading to an early diagnosis and treatment of the disease, such as in this case of an extremely rare germ cell tumor.PMID:35077441 | DOI:10.12659/AJCR.932616 (Source: Pain Physician)
Source: Pain Physician - January 25, 2022 Category: Anesthesiology Authors: Beka Aroshidze Lakshmi Boyapati Akriti Pokhrel Vladimir Gotlieb Abdullah Khan Burak Erdinc Muhammad Akhtar Cheema Source Type: research

The core four - A panel of immunohistochemistry markers to diagnose and subtype testicular germ cell tumors
Conclusions: Designing a novel concise and affordable IHC panel constituting OCT 3/4, CD117, GPC3, and CD30 has good sensitivity and specificity in differentiating seminomas, YST, and EC, respectively. Additional markers, namely β-HCG, can be used in identifying the choriocarcinoma component. (Source: Urology Annals)
Source: Urology Annals - January 20, 2022 Category: Urology & Nephrology Authors: VN Ranjitha Rashmi Khemani B Vishal Rao Daphne Fonseca S Sudha Murthy Ashwin Giridhar Y Jayakarthik Rakesh Sharma KV V. N. Raju T Subramanyeshwar Rao Challa Sundaram Source Type: research

Vulvar Yolk Sac Tumors Are Somatically Derived SMARCB1 (INI-1)-Deficient Neoplasms
So-called primary yolk sac tumors of the vulva are very rare and often have an aggressive disease course. Their molecular features have not been previously characterized. There is also a well-documented group of SMARCB1 (INI-1)-deficient vulvar neoplasms, which includes proximal-type epithelioid sarcoma and myoepithelial carcinoma. Until now, “vulvar yolk sac tumors” and SMARCB1-deficient neoplasms were considered unrelated diseases. After reviewing an index case of a vulvar yolk sac tumor with loss of SMARCB1 by immunohistochemistry, we retrospectively identified 2 additional cases diagnosed as vulvar yolk sac tumors....
Source: The American Journal of Surgical Pathology - January 19, 2022 Category: Pathology Tags: Original Articles Source Type: research