A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research

Molecules, Vol. 28, Pages 4978: Ultrasound-Assisted Extraction, Followed by Gas Chromatography & ndash;Mass Spectrometry for the Simultaneous Quantification of Ethinyl Estradiol and Drospirenone in Contraceptive Formulations
In this study, we have developed the first gas chromatography–mass spectrometry (GC–MS) method for the simultaneous quantification of 17α-ethinyl estradiol (EE) and drospirenone (DP) in contraceptive formulations. Under the final working conditions, analytes were extracted from the solid by ultrasound-assisted extraction (15 min) in methanol. The resulting suspension was diluted in ethyl acetate, subjected to centrifugation and, finally, the supernatant was directly injected into the GC–MS system. No derivatization reagents were utilized. To correct for instrumental v...
Source: Molecules - June 25, 2023 Category: Chemistry Authors: Javier Pe ña Iria Gonz ález-Mariño Jos é L. Pérez Pavón Tags: Article Source Type: research

High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity < i > in vitro < /i >
ConclusionsThe OC hormones EE and drospirenone do not directly enhance thrombin generation potential of primary ECsin vitro. (Source: PLoS One)
Source: PLoS One - April 19, 2023 Category: Biomedical Science Authors: Emma G. Bouck Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research

The Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice
Praxis (Bern 1994). 2023;112(4):199-204. doi: 10.1024/1661-8157/a003990.ABSTRACTThe Thromboembolism Risk with Combined Hormonal Contraceptives: Current Status and Prescribing Practice Abstract. The use of combined hormonal contraceptives (CHC) increases not only the risk for venous thromboembolism, but also for arterial thromboembolism. The risk for thromboembolism is the same for non-oral CHC (patches, vaginal rings) as for oral CHC. Risk factors such as age >35, obesity, smoking and a positive family history need to be recognized and considered in contraceptive counselling. Elaborate information concerning risks and b...
Source: Praxis - March 15, 2023 Category: General Medicine Authors: Dorothea Wunder Source Type: research