Systems Biology Interest Group: Learning to rewire cells
Systems Biology Interest Group Traditionally, biology has focused on deconstructing and mapping the molecular systems that carryout complex regulatory functions. We still lack, however, a more global understanding of the design principles governing how cells solve problems and make regulatory decisions. To address this problem, we have been complementing deconstructionist approaches with synthetic approaches in which we ask how to build molecular systems that can execute particular regulatory tasks. Are there a limited number of molecular algorithms that evolution can use to solve common physiological tasks? If so, can we ...
Source: Videocast - All Events - May 1, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell &nd...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

Exploring Molecular Linkages to Modifiable Risk in Breast Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds Dr. Gardner received his B.S. from Yale University and earned his M.D. and Ph.D. from the Johns Hopkins University School of Medicine where he studied the regulation of membrane skeletal proteins in the Department of Cellular Biology and Anatomy. He completed residency training in anatomic pathology at the National Cancer Institute and is board certified in Anatomic Pathology. Dr. Gardner has had a long term interest in the cellular and molecular biology of gene regulation and, while at NIH, has been developing strategies to define pathways and mechanisms of trans...
Source: Videocast - All Events - January 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

Driving CARs to BARs: The Road to Engineered Specific Human T Regulatory Cells
Immunology Interest Group David W. Scott, Ph.D. is Vice Chair for Research in the Department of Medicine at the Uniformed Services School of Health Sciences, Bethesda, MD. An alumnus of Antioch College, he received his M.S. degree from the University of Chicago and Ph.D. from Yale University in 1969. Following a post-doctoral fellowship at Oxford University, he has held tenured faculty positions at Duke University, the University of Rochester, and the University of Maryland Medical School. He assumed his current position in September 2010. Dr. Scott has contributed to over 200 research papers on several subjects on immuno...
Source: Videocast - All Events - June 10, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Nucleic Acid Detection in Host Defense and Autoimmunity
Immunology Interest Group Dan Stetson graduated from Duke University in 1997 and then received his Ph.D. in 2002 from the University of California, San Francisco, working in the lab of Richard Locksley. After completing postdoctoral work with Ruslan Medzhitov at Yale University, Dr. Stetson joined the University of Washington Department of Immunology in April 2008. Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All organisms have viral pathogens, and all organisms have sensors that detect foreign nucleic acids. In vertebrates, these sensors coordinate an inducible ...
Source: Videocast - All Events - April 7, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Long Non-coding RNAs and the Homeostasis of Innate Immune Cells
Immunology Interest Group Jorge Henao-Mejia obtained his M.D. in 2005 from the University of Antioquia, Medellin, Colombia and his Ph.D. in 2009 from Indiana University, Indianapolis. He was a post-doctoral fellow with Richard Flavell at Yale University, where he studied the interactions between the immune system and metabolism in the context of health and obesity. Since summer 2014, he has been on the Faculty at the University of Pennsylvania. His current research aims to understand the role of the innate immune system in the development of metabolic syndrome, and to comprehend the metabolic pathways that are necessary ...
Source: Videocast - All Events - April 1, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.
Immunology Interest Group Charles E. Egwuagu is Chief of the Molecular Immunology Section, National Eye Institute (NEI), NIH. He received his Ph.D in Epidemiology and Microbiology from Yale University Graduate School and a Master of Public Health (M.P.H) degree in Infectious Disease Epidemiology from Yale School of Medicine, New Haven, Connecticut. Dr. Egwuagu did a 2-year Post-doctoral Fellowship in Molecular Immunology at NEI/NIH and then served as a Commissioned Officer of the United States Public Health Service (PHS) for 10 years, attaining the rank of Captain (06). Research in the Egwuagu laboratory is on autoreacti...
Source: Videocast - All Events - February 18, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Fattening Up T Cell Memory
Presented by: Susan Kaech, Ph.D., Associate Professor of Immunobiology and HHMI Early Career Scientist, Yale UniversityCategory: ImmunologyAired date: 06/17/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - June 18, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Fattening Up T Cell Memory
Immunology Interest Group Dr. Susan Kaech is Associate Professor of Immunobiology and HHMI Early Career Scientist at Yale University. After receiving her Ph.D. from Stanford University for her studies in the field of developmental biology, Dr. Kaech joined the laboratory of Dr. Rafi Ahmed for her postdoctoral training. During this period, she made seminal discoveries in the area of effector and memory T cell development. In particular, she provided the first molecular and functional profiling of effector and memory CD8+ T cells and identified cellular precursors of long-lived memory CD8+ T cells. She became assistant prof...
Source: Videocast - All Events - June 10, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

2015 NIMH Autism Awareness Month Special Lecture
Audio PodcastPresented by: Kevin Pelphrey, Ph.D., Harris Professor in the Child Study Center and Professor of Psychology; Director of the Yale Center for Translational Developmental Neuroscience, Yale School of MedicineAired date: 4/6/2015 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 16, 2015 Category: Journals (General) Tags: Podcasts Source Type: video

2015 NIMH Autism Awareness Month Special Lecture
Video Podcast (CC)Presented by: Kevin Pelphrey, Ph.D., Harris Professor in the Child Study Center and Professor of Psychology; Director of the Yale Center for Translational Developmental Neuroscience, Yale School of MedicineAired date: 4/6/2015 2:00:00 PM Eastern Time (Source: Videocast Podcasts)
Source: Videocast Podcasts - April 6, 2015 Category: Journals (General) Authors: National Institutes of Health Tags: Health Source Type: video

2015 NIMH Autism Awareness Month Special Lecture
Audio PodcastPresented by: Kevin Pelphrey, Ph.D., Harris Professor in the Child Study Center and Professor of Psychology; Director of the Yale Center for Translational Developmental Neuroscience, Yale School of MedicineAired date: 4/6/2015 2:00:00 PM Eastern Time (Source: Videocast Podcasts)
Source: Videocast Podcasts - April 6, 2015 Category: Journals (General) Authors: National Institutes of Health Tags: Health Source Type: video

Initiation and Regulation of Toll-like Receptor Signal Transduction
Immunology Interest Group Dr. Jon Kagan is an Associate Professor of Pediatrics at Harvard Medical School and the Shwachman Chair in Gastroenterology at Boston Children's Hospital. He received his Ph.D. from Yale University in 2003 then conducted postdoctoral research in the laboratory of Ruslan Medzhitov until 2007. Jon studies the mechanisms of Pattern Recognition Receptor (PRR) signaling, with a focus on the role of cellular localization in controlling pathway activation. During his postdoctoral work, he made the important discovery that the activation of the MyD88 and TRIF branches of the LPS/TLR4 pathway is a sequen...
Source: Videocast - All Events - March 26, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Inflammation, dysbiosis and chronic disease
Presented by: Richard A. Flavell, Ph.D. FRS, Yale School of MedicineCategory: WALS - Wednesday Afternoon LecturesAired date: 03/18/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - March 19, 2015 Category: Journals (General) Tags: Past Events Source Type: video

David Derse Memorial Lecture and Award: Seeing Is Believing - Visualizing Individual Steps of the Retroviral Life Cycle
Presented by: Walther Mothes, Ph.D., Yale University School of MedicineCategory: SpecialAired date: 11/18/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 19, 2014 Category: Journals (General) Tags: Past Events Source Type: video

David Derse Memorial Lecture and Award: Seeing Is Believing - Visualizing Individual Steps of the Retroviral Life Cycle
Third Annual David Derse Memorial Lecture and Award The HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute is hosting the Annual David Derse Memorial Lecture & Award to honor the outstanding research accomplishments of David Derse and to stimulate the exchange of innovative ideas that he was well known for promoting throughout his scientific career. Walther Mothes, Ph.D. (Yale University School of Medicine) will deliver the third lecture in this annual series. The title of his presentation is "Seeing Is Believing – Visualizing Individual Steps of the Retroviral Life Cycle.&qu...
Source: Videocast - All Events - November 5, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Typhoid Toxin: A Window into the Unique Biology of Salmonella Typhi
Presented by: Jorge E. Galán, D.M.V., Ph.D., Lucille P. Markey Professor of Microbial Pathogenesis Chair, Department of Microbial Pathogenesis, Yale School of MedicineCategory: HHS OnlyAired date: 06/25/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - June 26, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Antiviral Defense Mechanisms at the Mucosal Surfaces
Presented by: Akiko Iwasaki, Ph.D., Howard Hughes Medical Institute Investigator, and Professor of Immunobiology and of Molecular, Cellular, and Developmental Biology at Yale School of MedicineCategory: NIH OnlyAired date: 05/14/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - May 15, 2014 Category: Journals (General) Tags: Past Events Source Type: video

State-Dependent Inhibition in the Cortex
Presented by: Jessica Cardin, PhD, Yale School of MedicineCategory: NeuroscienceAired date: 01/27/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - January 27, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Membrane Dynamics and Phosphoinositide Signaling in the Encocytic Pathway (NIH Only)
Presented by: Pietro De Camilli, MD, Yale University School of MedicineCategory: NIH OnlyAired date: 05/06/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - May 7, 2013 Category: Journals (General) Tags: Past Events Source Type: video

What are Cognitively Plausible Goals of Science Education?
Presented by: Frank C. Keil, Ph.D., Yale University: Folk biology, health literacy, and early science learning. Category: Science EducationAired date: 04/25/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - April 30, 2013 Category: Journals (General) Tags: Past Events Source Type: video

NIH Science Education Conversations Series #8
Presented by: Frank C. Keil, Ph.D., Yale University: Folk biology, health literacy, and early science learning. Category: Science EducationAired date: 04/25/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - April 30, 2013 Category: Journals (General) Tags: Past Events Source Type: video

Micronutrients and Cancer Prevention: A Complex World
Presented by: Susan Taylor Mayne, PhD, Yale UniversityCategory: Stars in NutritionAired date: 03/19/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - March 20, 2013 Category: Journals (General) Tags: Past Events Source Type: video

Removal of an Internally Migrated Pancreatic Duct Stent
Ara B. Sahakian, MD, Yale UniversityHarry Aslanian, M.D., Yale University James Ostroff, MD, University of California, San Francisco Priya A. Jamidar, MD, Yale University Pancreatic duct stents are useful in reducing the risk of post-ERCP pancreatitis. Risks of placing pancreatic duct stents include internal migration, difficult or failed placement, and ductal damage. Improper placement of pancreatic duct stents can predispose to migration. Removal of internally migrated pancreatic duct stents can be technically cha [...] (Source: The Digital Atlas of Video Education - Gastroenterology)
Source: The Digital Atlas of Video Education - Gastroenterology - February 25, 2013 Category: Gastroenterology Authors: admin Tags: Pancreas Source Type: video

Removal of an Internally Migrated Pancreatic Duct Stent
Ara B. Sahakian, MD, Yale University Priya A. Jamidar, MD, Yale University James Ostroff, MD, University of California, San Francisco Harry Aslanian, M.D., Yale University Pancreatic duct stents are useful in reducing the risk of post-ERCP pancreatitis. Risks of placing pancreatic duct stents include internal migration, difficult or failed placement, and ductal damage. Improper placement of pancreatic duct stents can predispose to migration. Removal of internally migrated pancreatic duct stents can be technically cha [...] (Source: The Digital Atlas of Video Education - Gastroenterology)
Source: The Digital Atlas of Video Education - Gastroenterology - February 25, 2013 Category: Gastroenterology Authors: admin Tags: Pancreas Source Type: video

Dilation, Stent Placement, and Electroincision of an Esophageal Stricture
Serag Dredar, MD, Yale University Harry Aslanian, M.D., Yale University A 67 yo male presented with dysphagia, 2 months after a distal esophagectomy for esophageal cancer. As shown here, the patient has a tight anastamotic stricture. Multiple staples can be seen adjacent to the stricture. A few of the staples were removed to allow for access to the esophageal lumen. A TTS dilation balloon catheter is just able to tr [...] (Source: The Digital Atlas of Video Education - Gastroenterology)
Source: The Digital Atlas of Video Education - Gastroenterology - December 21, 2012 Category: Gastroenterology Authors: admin Tags: Esophagus Source Type: video

Olfaction in Drosophila: Genetics and eGenetics
Presented by: John Carlson, Ph.D. Professor of Molecular, Cellular, and Developmental Biology, Yale UniversityCategory: WALS - Wednesday Afternoon LecturesAired date: 09/27/2000 (Source: Videocast - All Events)
Source: Videocast - All Events - September 27, 2000 Category: Journals (General) Tags: Past Events Source Type: video