Incidence of supraventricular tachycardia after inhaled short-acting beta agonist treatment in children.
Conclusions: SVT is rare during hospital-based treatment for acute asthma using inhaled SABAs and has low morbidity and mortality. PMID: 31902263 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - January 8, 2020 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Case report: Paradoxical responses to short acting beta-agonists in a pediatric patient.
Conclusion: This case highlights the need to include paradoxical response to SABAs in the differential of a patient with poorly controlled asthma. It also provides an example of successful treatment of a pediatric patient with a class of medications previously reserved for adults with chronic obstructive pulmonary disease. PMID: 31573361 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 3, 2019 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Short-acting bronchodilators for in-hospital management of acute exacerbation of COPD: Systematic Review
Introduction: No specific guidelines exist for administration of short-acting bronchodilator (SABD) for people hospitalised with acute exacerbation of chronic obstructive pulmonary disease (AECOPD); despite routine use in practice and risk of cardiac adverse events.Aim: To review evidence underpinning use and optimal dose, in terms of risk versus benefit, of SABD for inpatient management of AECOPD.Methods: A systematic search of Medline, Embase, CENTRAL and grey literature was conducted (up to December 2017) to identify relevant randomised controlled trials (RCT) or controlled clinical trials (CCT). Review methods were in ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kopsaftis, Z., Sulaiman, N., Carson, K., Mountain, O., Phillips, P., Smith, B. Tags: Clinical Problems Source Type: research

Enantiomeric impurity analysis using circular dichroism spectroscopy with United States Pharmacopeia liquid chromatographic methods
In this study, HPLC-CD was evaluated for enantiomeric purity determinations of 13 drug substances using HPLC methods consistent with assay protocols described in United States Pharmacopeia (USP) monographs. Of these selected substances, three (sitagliptin, timolol, and levalbuterol) showed no CD activity and one other (levofloxacin) could not be analyzed due to incompatibility of the mobile phase with the CD detector. For the remaining 9 substances, method validation was performed to determine the linearity, accuracy, precision and limits of quantitation of enantiomer impurities, which was compared to limits established by...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 11, 2018 Category: Drugs & Pharmacology Source Type: research

Change in Oxygen Consumption Following Inhalation of Albuterol in Comparison with Levalbuterol in Healthy Adult Volunteers
We examined changes in oxygen consumption (V ’O2) and heart rate (HR) following administration of albuterol and levalbuterol.MethodsThis is a prospective, randomized, single-blinded, controlled study of healthy adult volunteers. Subjects separately received albuterol (5  mg) and levalbuterol (2.5 mg) aerosolized over 15 min. V’O2 and vital signs were measured before the medications and 5, 10, 20, 40, and 60  min after.ResultsWe enrolled 24 volunteers with a median age of 32 years. Compared to baseline, there was a significant maximum increase in V ’O2 following administration of both a...
Source: Lung - February 16, 2017 Category: Respiratory Medicine Source Type: research

Clinical outcomes of levalbuterol versus racemic albuterol in pediatric patients with asthma: Propensity score matching approach in a medicaid population
ConclusionThis observational study of children aged 2–18 demonstrated levalbuterol prescription fills were associated with reduced ED visits, but not hospitalizations. Additional research may be necessary to assess this association. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - October 1, 2016 Category: Respiratory Medicine Authors: Jing Yuan, Zhiqiang Kevin Lu, Yanjun Zhang, Jun Wu, Bryan L. Love, Richard M. Schulz Tags: Original Article: Outcomes Source Type: research

Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction
Conclusions and clinical importanceLevalbuterol is as effective a bronchodilator as albuterol; although levalbuterol lasts twice as long as albuterol, its duration of action is still too short to make it practical for RAO treatment. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - May 1, 2016 Category: Veterinary Research Authors: M.G. Arroyo, L.L. Couëtil, N. Nogradi, M.M. Kamarudin, K.M. Ivester Tags: Standard Article Source Type: research

Principal findings of systematic reviews of acute asthma treatment in childhood.
CONCLUSIONS: SRCTs are useful for guiding decisions in acute asthma treatment. PMID: 26303207 [PubMed - in process] (Source: Journal of Asthma)
Source: Journal of Asthma - February 18, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Clinical outcomes and treatment cost comparison of levalbuterol versus albuterol in hospitalized adults with chronic obstructive pulmonary disease or asthma.
CONCLUSION: Clinical outcomes were similar with the use of levalbuterol versus albuterol for exacerbations of COPD or asthma. On average, patients receiving levalbuterol had longer and more costly hospital stays. PMID: 26025994 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - May 31, 2015 Category: Drugs & Pharmacology Authors: Brunetti L, Poiani G, Dhanaliwala F, Poppiti K, Kang H, Suh DC Tags: Am J Health Syst Pharm Source Type: research

Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells
Matthew J Randall, Shannon F Kostin, Edward J Burgess, Laura R Hoyt, Jennifer L Ather, Lennart K Lundblad and Matthew E Poynter (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 13, 2015 Category: Endocrinology Source Type: research

Advances in acute asthma
Purpose of reviewThe purpose of this study is to highlight some of the recent findings related with the management of acute exacerbations in the context of the emergency department setting. Recent findingsβ2-agonist heliox-driven nebulization significantly increased by 17% [95% confidence interval (CI) 5.2–29.4] peak expiratory flow, and decreased the rate of hospital admissions (risk ratio 0.77, 95% CI 0.62–0.98), compared with oxygen-driven nebulization. Other findings indicate that there is no robust evidence to support the use of intravenous or nebulized magnesium sulphate in adults with severe acute a...
Source: Current Opinion in Pulmonary Medicine - November 28, 2014 Category: Respiratory Medicine Tags: ASTHMA: Edited by Nicola A. Hanania and Zuzana Diamant Source Type: research

Economic Impact of Levalbuterol Versus Albuterol in Low-Income Population
The objective of this study is, therefore, to examine the economic impact of levalbuterol versus albuterol on total health care expenditure in a high-risk, low income asthma population. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: J. Yuan, K. Lu Source Type: research

Validation of a population‐based method to assess drug‐induced alterations in the QT interval: a self‐controlled crossover study
ConclusionsQT prolonging effects were common and varied in strength. Our results lend support to past Food and Drug Administration regulatory actions and support the role for ongoing surveillance of drug‐induced QT prolongation. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 1, 2013 Category: Drugs & Pharmacology Authors: Carlos Iribarren, Alfred D. Round, Jonathan A. Peng, Meng Lu, Jonathan G. Zaroff, Taylor J. Holve, Amit Prasad, Paul Stang Tags: Original Report Source Type: research

A comparison of heart rate changes associated with levalbuterol and racemic albuterol in pediatric cardiology patients.
CONCLUSIONS: Racemic albuterol and levalbuterol were associated with increased heart rate in pediatric cardiology patients. This increase was found to be equivalent. PMID: 23613097 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 1, 2013 Category: Drugs & Pharmacology Authors: Kelly A, Kennedy A, John BM, Duane B, Lemanowicz J, Little J Tags: Ann Pharmacother Source Type: research

HyperK and Shades of Grey: Myths and Facts about Hyperkalemia Part II
Today we continue our discussion about the myths and facts of hyperkalemia with Dr. Brooks Walsh, author of the Mill Hill Ave Command blog. We also feature contributions from Dr. Stephen Smith, of Dr. Smith's ECG Blog. If you would like to refresh your memory on Part I visit here.                                          Dr. Walsh and I spoke about why he thought hyperkalemia presented such a challenge for EMS providers: "The recognition and treatment of hyperkalemia is one of those areas in medicine wher...
Source: EMS 12-Lead - January 14, 2013 Category: Cardiology Authors: David Baumrind Tags: ems-health-safety ems-topics patient-management Training training-development 12-Lead ECG Brooks Walsh M.D. David Baumrind hyperkalemia Myths Paramedic Stephen Smith M.D. Source Type: research