Integrative roles of microRNAs in lipid metabolism and dyslipidemia
This article reviews examples of miRNAs that bridge disparate metabolic pathways in the liver. For example, we highlight miRNAs that are regulated by the sterol-sensing pathway in the liver that in turn regulate cellular or systemic cholesterol, fatty acid, and glucose levels.
Recent findings
The most widely studied of these miRNAs are miR-33a/b; however, we recently reported that miRNAs in the miR-183/96/182 cluster are also likely regulated by hepatic cholesterol content and mediate the observed glucose-lowering effects of the bile acid sequestrant colesevelam through the sterol-sensing pathway. In addition, several o...
Source: Current Opinion in Lipidology - May 2, 2019 Category: Lipidology Tags: LIPID METABOLISM: Edited by Marit Westerterp and Bart van de Sluis Source Type: research
Expanded Table: Lipid-Lowering Drugs (online only)
Date: February 11, 2019
Issue #:
1565Summary:
View the Expanded Table: Lipid-Lowering Drugs (Source: The Medical Letter)
Source: The Medical Letter - February 1, 2019 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab Altoprev Antara Atorvastatin Cholesterol Cholestyramine Colesevelam Colestid Colestipol Crestor Epanova Ezetimibe ezetimibe/simvastatin Fenofibrate Fenofibric acid Fenoglide Fibricor Fish oil Flolipid Fluva Source Type: research
Lipid-Lowering Drugs
Date: February 11, 2019
Issue #:
1565Summary:
Cholesterol management guidelines from the American
College of Cardiology/American Heart Association Task
Force have recently been published. See Table 1 for a
brief summary of their recommendations. (Source: The Medical Letter)
Source: The Medical Letter - January 8, 2019 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab Altoprev Antara Atorvastatin Bezafibrate Bezalip Cholesterol Cholestyramine Colesevelam Colestid Colestipol Crestor Epanova evolucumab Ezetimibe ezetimibe/simvastatin Ezetrol Fenofibrate Fenofibric acid Fen Source Type: research
Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model
ConclusionBoth budesonide and colesevelam show potential as effective interventions against neratinib-induced diarrhea. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - December 10, 2018 Category: Cancer & Oncology Source Type: research
A novel analytical approach towards in-vitro bile acid binding studies to Colesevelam Hydrochloride tablets: An ultra-high performance liquid chromatography tandem mass spectrometric method
The objective of the study was to develop and validate a liquid chromatography tandem mass spectroscopic method for the simultaneous in-vitro estimation of bile acid salts of Glycocholic acid (GC), Glycochenodeoxycholic acid (GCDC) and Taurodeoxycholic acid (TDC) and its application in performing in-vitro binding study with Colesevelam Hydrochloride tablets. The method was developed using C-18 (50 x 4.6 mm, 3 μm) column with detection on negative ion mode and acquisition time of 3.5 min. The calibration range was linear from 0.0002 mM to 0.0065 mM for GC, 0.0002 mM to 0.0065 mM for GCDC and 0.0001 mM t...
Source: Journal of Pharmaceutical and Biomedical Analysis - December 6, 2018 Category: Drugs & Pharmacology Source Type: research
Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - October 19, 2018 Category: Drugs & Pharmacology Authors: Henriette Holst Nerild Mikkel Bring Christensen Filip Krag Knop Andreas Br ønden Source Type: research
Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes.
Abstract
Colesevelam is a bile acid sequestrant approved to treat both hyperlipidemia and type 2 diabetes, but the mechanism for its glucose lowering effects is not fully understood. The aim of this study was to investigate the role of hepatic microRNA's as regulators of metabolic disease and to investigate the link between the cholesterol and glucose lowering effects of colesevelam. To quantify the impact of colesevelam treatment in rodent models of diabetes, metabolic studies were performed in Zucker Diabetic Fatty (ZDF) rats and db/db mice. Colesevelam treatments significantly decreased plasma glucose l...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 30, 2018 Category: Physiology Authors: Sedgeman LR, Beysen C, Allen RM, Ramirez Solano MA, Turner SM, Vickers KC Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Bile acid sequestrant colesevelam enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice
Aim: We previously showed that brown fat activation accelerates the clearance of cholesterol-enriched remnants by the liver, thus reducing hypercholesterolemia and improving HDL functionality, consequently protecting against atherosclerosis development (Nat Commun 2015; Nat Commun 2017). Liver cholesterol is the main substrate for the synthesis of bile acids (BAs) that are secreted into the intestine and recycled via the enterohepatic circulation. Since the impact of brown fat activation on BA metabolism is still obscure, we now aimed to evaluate the effects of brown fat activation on cholesterol and BA metabolism without ...
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: E. Zhou, G. Hoeke, A.C. Eibergen, Z. Wang, R.H. Havinga, A.K. Groen, M.R. Boon, P.C.N. Rensen, J.F.P. Berbee, Y. Wang Tags: Dyslipidemia Source Type: research
Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature.
We report the use of the farnesoid X receptor agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure. A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue. The diarrhea resulted in hypokalemia and sodium depletion that made her dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional therapies with colestyramine, colesevelam, and loperamide had no effect. Second-line antisecretory therapies with pantoprazole, lir...
Source: World Journal of Gastroenterology : WJG - June 7, 2018 Category: Gastroenterology Authors: Hvas CL, Ott P, Paine P, Lal S, Jørgensen SP, Dahlerup JF Tags: World J Gastroenterol Source Type: research
Effectiveness and safety of combinational therapy compared with intensified statin monotherapy in patients with coronary heart disease.
In conclusion, statins combined with colesevelam or ezetimibe were more effective in reducing plasma LDL-C levels than high-intensity statin monotherapy. This combinational therapeutic strategy may be an alternative for patients that are resistant or intolerant to statins.
PMID: 29805487 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 30, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research
Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
D Dutta, S Kalra, M SharmaJournal of Postgraduate Medicine 2017 63(2):114-121The current classification of both diabetes and antidiabetes medication is complex, preventing a treating physician from choosing the most appropriate treatment for an individual patient, sometimes resulting in patient-drug mismatch. We propose a novel, simple systematic classification of drugs, based on their effect on adenosine monophosphate-activated protein kinase (AMPK). AMPK is the master regular of energy metabolism, an energy sensor, activated when cellular energy levels are low, resulting in activation of catabolic process, and inactivati...
Source: Journal of Postgraduate Medicine - April 10, 2017 Category: Internal Medicine Authors: D Dutta S Kalra M Sharma Source Type: research
Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review.
Abstract
PURPOSE: Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small amounts (micrograms), which makes interactions in the absorption phase clinically significant. The main aim of this article was to review and present the latest information on factors that affect the gastrointestinal absorption of this drug.
METHODS: Relevant data were collected by using the MEDLINE, PubMed, EMBASE, Web of Science, Science Direct, and Scopus databases with the key words levothyroxine and absorption. Searches were not limited to specific publication types, study designs, dates, or lang...
Source: Clinical Therapeutics - January 29, 2017 Category: Drugs & Pharmacology Authors: Skelin M, Lucijanić T, Amidžić Klarić D, Rešić A, Bakula M, Liberati-Čizmek AM, Gharib H, Rahelić D Tags: Clin Ther Source Type: research
Effectiveness and Tolerability of Colesevelam HCl for Accelerated Elimination of Teriflunomide in Healthy Participants.
PMID: 28120422 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - January 24, 2017 Category: Drugs & Pharmacology Authors: Lunven C, Guo Z, Turpault S, Delfolie A, Fauchoux N, Turner T, Baldinetti F Tags: J Clin Pharmacol Source Type: research
75SeHCAT scan in bile acid malabsorption in chronic diarrhea
Publication date: January–February 2017 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 36, Issue 1 Author(s): L.M. Mena Bares, E. Carmona Asenjo, M.V. García Sánchez, E. Moreno Ortega, F.R. Maza Muret, M.V. Guiote Moreno, A.M. Santos Bueno, E. Iglesias Flores, J.M. Benítez Cantero, J.A. Vallejo Casas Chronic diarrhoea is a common entity in daily clinical practice and it leads to a loss in these patients quality of life. It may be the main symptom of multiple ethiologies including bile acid malabsorption (BAM) which has a comparable prevalence to celiac disease. Th...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - December 28, 2016 Category: Nuclear Medicine Source Type: research
