Outcomes of atypical (B3) core biopsy lesions diagnosed across BreastScreen NSW, Australia
CONCLUSIONS: The overall upgrade rate of B3 lesions to malignancy was 26.4%. The majority of the lesions were upgraded to DCIS instead of invasive cancer. Upgrade rates varied by lesion type. Lesions with atypia had significantly higher upgrade rates to cancer compared to lesions without atypia. Malignant lesions were significantly larger than benign lesions.PMID:38564975 | PMC:PMC10993176 | DOI:10.1016/j.breast.2024.103720 (Source: Breast)
Source: Breast - April 2, 2024 Category: Cancer & Oncology Authors: Richard Chou Diana Tran Joseph Descallar Bin Jalaludin Patsy S Soon Source Type: research
Outcomes of atypical (B3) core biopsy lesions diagnosed across BreastScreen NSW, Australia
CONCLUSIONS: The overall upgrade rate of B3 lesions to malignancy was 26.4%. The majority of the lesions were upgraded to DCIS instead of invasive cancer. Upgrade rates varied by lesion type. Lesions with atypia had significantly higher upgrade rates to cancer compared to lesions without atypia. Malignant lesions were significantly larger than benign lesions.PMID:38564975 | PMC:PMC10993176 | DOI:10.1016/j.breast.2024.103720 (Source: Breast)
Source: Breast - April 2, 2024 Category: Cancer & Oncology Authors: Richard Chou Diana Tran Joseph Descallar Bin Jalaludin Patsy S Soon Source Type: research
Implementation and evaluation of the Supportive and Palliative Care Indicators Tool (SPICT ™) in acute care
CONCLUSIONS: The study emphasises the critical need for addressing ACP and palliative care among older patients with life-limiting conditions. It underscores the importance of timely discussions, documentation, and cessation of futile interventions.PMID:38558296 | DOI:10.1111/ajag.13308 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 1, 2024 Category: Geriatrics Authors: Olivia Paulik Robyn Whitaker Monita Mesuria Debbie Wong Katie Swanson Heidi Green Nqobile Sikhosana Ritin Fernandez Source Type: research
Implementation and evaluation of the Supportive and Palliative Care Indicators Tool (SPICT ™) in acute care
CONCLUSIONS: The study emphasises the critical need for addressing ACP and palliative care among older patients with life-limiting conditions. It underscores the importance of timely discussions, documentation, and cessation of futile interventions.PMID:38558296 | DOI:10.1111/ajag.13308 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 1, 2024 Category: Geriatrics Authors: Olivia Paulik Robyn Whitaker Monita Mesuria Debbie Wong Katie Swanson Heidi Green Nqobile Sikhosana Ritin Fernandez Source Type: research
Implementation and evaluation of the Supportive and Palliative Care Indicators Tool (SPICT ™) in acute care
CONCLUSIONS: The study emphasises the critical need for addressing ACP and palliative care among older patients with life-limiting conditions. It underscores the importance of timely discussions, documentation, and cessation of futile interventions.PMID:38558296 | DOI:10.1111/ajag.13308 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 1, 2024 Category: Geriatrics Authors: Olivia Paulik Robyn Whitaker Monita Mesuria Debbie Wong Katie Swanson Heidi Green Nqobile Sikhosana Ritin Fernandez Source Type: research
164 Participant recollection of recent imaging is unreliable for determining eligibility for lung cancer screening
Targeted low-dose CT screening for lung cancer has been recommended for implementation in the UK and is already underway in England as Targeted Lung Health Checks (TLHCs). Individuals who have undergone thoracic CT imaging in the last 12 months, or are planned to in the next 3 months, are unlikely to benefit and should be deferred. The TLHC standard protocol states that “if a participant mentions [a prior thoracic CT], reasonable steps should be taken to assess whether [this] has taken place.” We explored frequency and participant recollection of previous imaging in the Lung Health Check (LHC) Operational Pilot (OP) fo...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Elizabeth Sharkey, Lyndsey Haffenden, Julie Thomas, Sinan Eccles Tags: Screening Source Type: research
163 Optimising uptake of the Lung Health Check Operational Pilot within a socioeconomically deprived area of Wales
The Lung Health Check (LHC) Operational Pilot for Wales will enable preparation for a national lung cancer screening programme roll-out. Known barriers to participation in LHCs include smoking-related stigma, fear and fatalism, particularly amongst those living in socioeconomically deprived areas. We used evidence-based best practice when planning the Operational Pilot with the aim of optimising uptake. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Chris Coslett, CIaire Wright, Amy Smith, McCutchan Grace, Samantha Quaife, Kate Brain, Dafydd Snelling, Heather Ramessur-Marsden, Sinan Eccles Tags: Screening Source Type: research
160 Updating primary care smoking records by text message in preparation for lung cancer screening in Wales
Targeted lung cancer screening requires identification of current and ex-smokers ( “ever-smokers”). Primary care records can be used to identify ever-smokers but the completeness and accuracy of this data is variable, and updating records can be resource-intense. We assessed the completeness of smoking data (recorded as “tobacco codes”) in primary care records in Wales and developed a toolkit to update missing smoking status data using an automated text message system. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Sinan Eccles, Jean Engela-Volker, Nicole Abel, Amy Smith, Claire Wright, Chris Coslett Tags: Screening Source Type: research
150 Outcomes After Curative-Intent Radiotherapy for Lung Cancer with Driver Mutations: A Retrospective Multicentre Case-Control Study
Molecular analysis is increasingly available for non-metastatic NSCLC across the UK. Whilst patients with NSCLC and driver mutations have worse outcomes following surgery, chemotherapy and immunotherapy compared to patients with ‘wildtype’ tumours, there is a dearth of outcome data in the setting of curative-intent radiotherapy. A retrospective, multicentre, case-control study was undertaken by the British Thoracic Oncology Group trainee network in order to determine if common driver mutations impact outcomes after radi otherapy. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Salman Ashraf, Madeha Khan, Nada Naguib, Robert Rulach, Katharine Welsh, Rebecca Carozzi, Ashley Horne, Amelia Payne, Mary Denholm, Georgia Stewart, Ahmed Bedair, Stephen Harrow, Corinne Faivre-Finn, Jonathan McAleese, Gerard Hanna, Allan Hackshaw, Fiona Tags: Radiotherapy Source Type: research
149 Stereotactic radiosurgery (SRS) for the treatment of brain metastases: Outcomes for lung cancer patients in South Wales
Brain metastases from lung cancer are the commonest intracranial malignant tumours. As treatments for lung cancer improve, management of brain metastases has evolved. SRS treatment for good prognosis patients with volume (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Sarah Walters, Ashley Poon-King, Amy Case, Jillian Maclean, James Powell, Najmus Sahar Iqbal Tags: Radiotherapy Source Type: research
68 How do family members experience coroner or procurator fiscal involvement following a mesothelioma death?
A death caused by known or suspected mesothelioma in England, Wales and Northern Ireland must, by law, be referred to a coroner for an inquest. In Scotland, the equivalent is referral to the Procurator Fiscal for a Fatal Accident Enquiry. Practice following a mesothelioma death varies across the UK. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Bethany Taylor, Clare Gardiner, Sarah Hargreaves, Angela Tod Tags: Mesothelioma Source Type: research
39 A multi-centre analysis of the performance of EBUS-TBNA testing for comprehensive molecular profiling in non-small cell lung cancer (NSCLC)
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an important diagnostic tool in lung cancer. Since 2021, the National Optimal Pathway for Lung Cancer in Wales has mandated reflex testing, using Next Generation Sequencing (NGS) for all stage non-small cell lung cancer in line with ESMO recommendations. The utilisation of NGS technologies in EBUS-TBNA specimens has been questioned, especially relating to the volume of tissue needed for successful DNA and RNA analysis. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Craig Dyer, Kelly Marshall, Robin Ghosal, Rhian Williams Tags: Diagnosis and Staging Source Type: research
A five-year review of chemoradiotherapy practice in anal cancer: Radiotherapy audit results from a cancer centre in Wales, UK
CONCLUSION: Audit results matched with the standards in six domains. Overall treatment time of 37.9 days, colostomy rates of 1.2%, and the 30-day mortality rate of 1.2% were commendable. Overall time interval between consent and CRT delivery can be achieved by time-constrained measures.PMID:38553430 | DOI:10.1177/03008916241241424 (Source: Tumori)
Source: Tumori - March 30, 2024 Category: Cancer & Oncology Authors: Mutahar A Tunio Nicki Davies Elliot Caparros Janis Davies Stuart Foyle Source Type: research
